DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fwd and Pi3K59F

DIOPT Version :9

Sequence 1:	NP_001356971.1	Gene:	fwd / 45374	FlyBaseID:	FBgn0004373	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster

Alignment Length:	771	Identity:	166/771 - (21%)
Similarity:	277/771 - (35%)	Gaps:	239/771 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1047 LAKKTHHRSQSDATVLLADFRSPHTLSISHRM----YQQPPYTTQTLPTTPAKLCLGDLT----- 1102
            |.::.|||........::|..:..|.||..::    |:.||  |..|.:...     ||.
  Fly   266 LVERKHHRLARSERSGISDRDAKPTASIRDQLHTIVYRYPP--TYVLSSEEQ-----DLVWKFRF 323

  Fly  1103 --SGHAFDNGCTCFETVRGQVNGLLGQRTLCSCGAPKTSPQKEFMKALMNVGKNLTSWPSKAEKT 1165
              |.|                     ::.|           .:|:|.:        :|..:.|.|
  Fly   324 YLSSH---------------------KKAL-----------TKFLKCI--------NWKLEDEVT 348

  Fly  1166 SALRMSLNLINKNLPARVWLPLYSDIPHHVVRITEEKTAVLNSKDKTPYIIYVEVVEIPDIYTSP 1230
            .||.|..|          |.|:  |:        |:...:|:.....|.:....|..:.......
  Fly   349 QALWMLAN----------WAPM--DV--------EDALELLSPTFTHPQVRKYAVSRLAQAPDED 393

  Fly  1231 LIPKMMPSLRHTKSEE-----HLDG----------SCLNSHQHL----SCSRTSSCSSSQQGTSC 1276
            |:..::..::..|.|:     ||.|          |.|:.:..|    |.|..|:.||...|:..
  Fly   394 LLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVI 458

  Fly  1277 -RRKKGADV--------------DGGCGDAG--------------------PHNSCSNVHSLG-G 1305
             ..::.|.|              .||.|..|                    |.:|.||...|. |
  Fly   459 PANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEG 523

  Fly  1306 LQFQEDDV---------------------W--SQEEDEITAQYLNMRKVSERDTISQISLDSCDS 1347
            :.|.....                     |  |.|.:|:.    ::||..||            :
  Fly   524 ISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVE----SVRKQDER------------A 572

  Fly  1348 RDQGPPV------VFNIGDVRLRHC-SNLSCENTKSFSNDPEDPSAAALKEPWH-----EK-EKL 1399
            .|....|      |...|:..||.. .||  ...:.|.::.........|||.:     || :||
  Fly   573 HDMYAMVLKMFLKVLENGNFNLRGIFYNL--RKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKL 635

  Fly  1400 IRESSPYG-HLSNWRLL-----------------------------------------SAIVKCG 1422
            :.|...:. :.:|:..:                                         :||.|.|
  Fly   636 LAEQDMFKVNFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAIFKHG 700

  Fly  1423 DDLRQELMATQLLQMFKIIWQEEQVDLWVRPYKIVCLSNDSGLIEPILNTVSLHQIKKNSNKSLK 1487
            |||||:.:..|::.:...:.:.|.:||.:.|||::..|:..|.::.:.:......:.:..|  :.
  Fly   701 DDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTVAEVLAREGN--IH 763

  Fly  1488 EYFIDEY---GSPSGESFRRAQKNFVQSCAAYCLISYLLQVKDRHNGNILFHSDGHIIHIDFGFI 1549
            .:|...:   ..|.|.| ......:::|||.||:|:|||.|.|||..|:|..::|.:.|||||:|
  Fly   764 NFFRKHHPCDNGPYGIS-AEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYI 827

  Fly  1550 LSISPKNLGFEQSPFKLTPEFVEVMGGTSSEHWREFNKLLLVGMMSARKHMDRIINFVEIMRSNA 1614
            |...||.:   ..|.||:.|.||.|||.||||..||.|......:..|:|.:.::|...:| .:|
  Fly   828 LGRDPKPM---PPPMKLSKEMVEAMGGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLM-VDA 888

  Fly  1615 HLPCFKNGCSGTVQNLRKRFHMNLTEQEMERKVEQLVQDSLKSLSTKLYDGYQYYT 1670
            .:|.........|:.:.:...:.||::|..:.::.|:..|:.::...|.:....:|
  Fly   889 TVPDIALEPDKAVKKVEENLQLGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFT 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	87/337 (26%)
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042
		PI3Ka_III	284..561	CDD:238442	61/343 (18%)
		PI3Kc_III	601..945	CDD:270628	89/353 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447465
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10072at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10048
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850