DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fwd and Sh3pxd2b

DIOPT Version :9

Sequence 1:	NP_001356971.1	Gene:	fwd / 45374	FlyBaseID:	FBgn0004373	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	XP_006514775.1	Gene:	Sh3pxd2b / 268396	MGIID:	2442062	Length:	936	Species:	Mus musculus

Alignment Length:	434	Identity:	86/434 - (19%)
Similarity:	144/434 - (33%)	Gaps:	83/434 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   492 GNGSSSSNNSCSSAGSTKKREDLTSLGSDDSGIIC------GSESDQISLNRICHSHESLDSGEM 550
            |:.:::.||:...|....:.......|:.|||::.      |.|:.     |...|..|..:|..
Mouse   478 GDAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKGGKEAP-----RKASSDLSASTGYE 537

  Fly   551 DADADAEEECVDL--MDTTSIDEEYNIMQPDHLCLYPPQAASTELDCRTL-------RPSRKQKR 606
            :.....:||...|  ...:.|..|..:::.:...:.|.:.:|.:.....|       .|..:..|
Mouse   538 EISDPTQEEKPSLPPRKESIIKSEEELLERERQKMEPLRGSSPKPPGMILPMIPAKHAPLARDSR 602

  Fly   607 QQQQVLERKNLPSQNQ--IESEDSVDAGVDARTRYRVMNMSQAAINVELGTASNEIDPDVNYRES 669
            :.:..|::...|.:|.  :|....|.|....:...|.::.|:|.::.|      ::||
Mouse   603 KPEPKLDKSKFPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELSEE------KVDP------- 654

  Fly   670 HQDPIADAPSLSTPSVASTASATPSVTPTPIATPTPTESTKNDQVLFKNFFGATKNAIFRTAQSI 734
                         .|......:.|.|.|.|..:|....:...|.|...|.....:.|  ::.:..
Mouse   655 -------------TSQNLFMKSRPQVRPKPTPSPKTEPAQSEDHVDIYNLRSKLRPA--KSQEKA 704

  Fly   735 IENHEKKNAAKQKEQPDHSGTVSLVGSPNGGSSVPQDLVKSPTDISKKKEFFSLLTSSSSIKAAA 799
            :.:.|..:||     ..|...:|....|..|....||.......:|.|             :...
Mouse   705 LLDGESHHAA-----GSHDTALSRSFLPGEGPGHGQDRSGRQDGLSPK-------------ETPC 751

  Fly   800 AAAANSAASTPPATPTEALAANSNSKLQ-----PLSDPSADLKVKERTLNLR-LPGDSEGSEGAL 858
            .|....|.:|.|. |.........:.||     |...|....|.....|:.| ||    ...||.
Mouse   752 RAPPRPAKTTDPG-PKNVPVPVQEATLQQRPVVPPRRPPPPKKTSSSPLSCRPLP----EVRGAQ 811

  Fly   859 TKCSSINSIHKLKLPVPGVVKYFISEKAPVSDVLQKPEKGQSGL 902
            .:.|.:.......|.||...|.|:|.    |.|.|...:|:.||
Mouse   812 REESRVAPAAGRALLVPPKAKPFLSN----SSVGQDDMRGKGGL 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712
Sh3pxd2b	XP_006514775.1	PX_FISH	7..125	CDD:132798
		SH3_Tks4_1	155..209	CDD:213008
		SH3_Tks4_2	252..305	CDD:213009
		SH3_Tks4_3	400..452	CDD:213011
		SH3_Tks4_4	879..934	CDD:212951
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900