Protein Alignment fwd and pik1

DIOPT Version :10

• Sequence 1: NP_001356971.1
• Gene: fwd / 45374
• FlyBaseID: FBgn0004373
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: NP_594842.1
• Gene: pik1 / 2541887
• PomBaseID: SPAC22E12.16C
• Length: 851
• Species: Schizosaccharomyces pombe
• Alignment Length: 906
• Identity: 272/906 - (30%)
• Similarity: 425/906 - (46%)
• Gaps: 192/906 - (21%)

  Fly   898 GQSGLLRFFESPVFNIHFAVHYLF-YSKEPGVLSFIGNKIFSFPDQEVDLYIPQLVVMYIQMDEL 961
            |...|||||||..|.....|.||. |....|:..|:..|:.:||.:|::.:||||:.:.:..|..
pombe     7 GNELLLRFFESAHFTSQLCVAYLSRYPNNIGIHHFLCEKLATFPYEEIEFFIPQLIHLVLNKDSE 71

  Fly   962 AEVLDPYLTIRCRKSVDFSLKCLWLLEAYNYQVDSLGNSHNSSRKSKLALMKEIFSK-------- 1018
            :..|:.::..:|.::...:|...|.|:|  :.||.....|:|..|    :.|.::::
pombe    72 SVALEEFIISQCEQNTQCALITFWYLQA--HMVDLGLQPHSSCFK----ICKRLYNRIQILVFMS 130

  Fly  1019 ------REHKQTQN-----DLKSAGTGGLHVGEPRS-----VVALAKKTHHR--SQSDATVLLAD 1065
                  .:.|.::|     .|.....||:.|.|...     .:|..:|...:  .:||..||
pombe   131 SSSLIQSQQKISENVTPALILSGIMLGGVCVPELLKKAGPIAIAQGRKAPRQDPDESDVDVL--- 192

  Fly  1066 FRSPHTLSISHRMYQQPPYTTQTLPTT------------PAKLCLGDLTSGHAFDNGCT-CFETV 1117
                      .|:..:|.|:...|.::            ..:|...:||..|::.:..| ..:..
pombe   193 ----------RRLSTEPRYSLDVLRSSLNNSIVEQHSEVSLRLKAPELTRTHSYQSSATLSIDEQ 247

  Fly  1118 RGQVNGLLGQRTLCSCGAPKTSPQKEFMKALMNVGKNLTSWPSKAEKTSALRMSLNLINKNLPAR 1182
            |..:.....|:.:            :|:.||.::...|...|.:| :.|:||..|.|:|.||||.
pombe   248 RRVLRSNYFQQEI------------QFLFALQDISIRLIIVPRQA-RLSSLRAELALLNNNLPAD 299

  Fly  1183 VWLPL----YSDIPHHVVRITEEKTAVLNSKDKTPYIIYVEVV---------------------- 1221
            |.:||    :.::.|.:|||..::..:|||.::.||:|.|||:
pombe   300 VNIPLLRSYHKEVSHKIVRIDPKEATILNSAERVPYLIMVEVLSGELSFEPQSKKNKAKVQKIVS 364

  Fly  1222 ---------EIPDI--YTSPLIPKMMPSLRHTKSEEHLDGSCLNSHQ----------HLSCSRTS 1265
                     ::.|:  ||:     :..|..:..||...:|..|:...          .||.|.:|
pombe   365 HKNQRKRWFDLTDVDPYTN-----LQDSTDNDISESESEGGDLSMSPLIKGLVPDTLSLSKSFSS 424

  Fly  1266 SCSSSQQGTSCRRKKGADVDGGCGDAGPHNSCSNVHSLGGLQFQEDDVWSQEEDEITAQYLNMRK 1330
            ..:.|.|..|..|    |.|              |..|.|.....|...:.:..:|.|..:..|.
pombe   425 FGNVSLQVPSSHR----DTD--------------VVLLSGRHSDSDGNGALKRSKIYASEITARM 471

  Fly  1331 VSERDTISQISLDSCDSRDQGPPV----------VFNIGDVRLRHCS------NLSCENTKSF-- 1377
            .:....:||  ||:..||......          :..:.:.||...|      ::||.....|
pombe   472 RAAATMLSQ--LDAEGSRRPKAETERIKNSIILDMQRLEEERLNEPSIYPVSVDISCAEDLRFGK 534

  Fly  1378 -------SNDPEDPSAAALKEPWHEKEKLIRESSPYGHLSNWRLLSAIVKCGDDLRQELMATQLL 1435
                   ..|.:|||||..:|.|:.|::.||:||||||..||.|:|.|||.|.|||||..|.||:
pombe   535 ETQKAERKGDRDDPSAATFQEDWYAKKERIRKSSPYGHYPNWDLVSVIVKTGADLRQETFACQLI 599

  Fly  1436 QMFKIIWQEEQVDLWVRPYKIVCLSNDSGLIEPILNTVSLHQIKKNSNK---------------- 1484
            ..|:.:|.|.:..:|||..||:...::|||||.|.|.:|:|.||||..|
pombe   600 YAFQRVWLECKEKVWVRRMKILVTGDNSGLIETITNAISVHSIKKNLTKQLREAELAQGKIAGKN 664

  Fly  1485 --SLKEYFIDEYGSPSGESFRRAQKNFVQSCAAYCLISYLLQVKDRHNGNILFHSDGHIIHIDFG 1547
              :||:|||.::|.|:...:|:||.||:||..||.:||||||:|||||||:|..|:|||||||||
pombe   665 VVTLKDYFIKQFGDPNSSRYRQAQTNFLQSLVAYSIISYLLQLKDRHNGNVLIDSEGHIIHIDFG 729

  Fly  1548 FILSISPKNLGFEQSPFKLTPEFVEVMGGTSSEHWREFNKLLLVGMMSARKHMDRIINFVEIMRS 1612
            |:|:.:|.|:|||.:|||||.:::|::    .:.:.|:..|:.....|.||:.|:||..||:|::
pombe   730 FLLTNTPGNVGFESAPFKLTADYLEIL----DDRFDEYRSLMKAAFKSVRKNADQIILLVEVMQN 790

  Fly  1613 NAHLPCFKNGCSGTVQNLRKRFHMNLTEQEMERKVEQLVQDSLKSLSTKLYDGYQYYTNGI 1673
            |:.:|||:.| ..|...|.:||.:.|.::|.:..|:.|:|.:..|:.|:|||.:|..||||
pombe   791 NSTMPCFRAG-ENTSAQLLQRFQLQLGDKECDDFVDLLIQKANCSVWTRLYDLFQNITNGI 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	140/307 (46%)
pik1	NP_594842.1	TEL1	<1..851	CDD:227365	272/906 (30%)
		PI4Kc_III_beta	549..851	CDD:270712	140/307 (46%)