DRSC/TRiP Functional Genomics Resources

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Protein Alignment fwd and SMG1

DIOPT Version :9

Sequence 1:NP_001356971.1 Gene:fwd / 45374 FlyBaseID:FBgn0004373 Length:1682 Species:Drosophila melanogaster
Sequence 2:XP_005255239.1 Gene:SMG1 / 23049 HGNCID:30045 Length:3689 Species:Homo sapiens


Alignment Length:2042 Identity:358/2042 - (17%)
Similarity:632/2042 - (30%) Gaps:706/2042 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 PNNCYQ-----YLRHIREIDTNNKLLSPVVVVAEERPVSKAG------------SPSTVATMATG 82
            |..|.:     :..|:..:| |.|.    ||:.:...::..|            ||:..|.::..
Human   586 PEACSEIKHEAFKNHVFNVD-NAKF----VVIFDLSALTTIGNAKNSLIGMWALSPTVFALLSKN 645

  Fly    83 VDVV--------------------DHCLPTTVRLSVTEALSDLNMNGKAVEPPVTPCTS------ 121
            :.:|                    .||......:|.:.:.|..::...||...||..|.      
Human   646 LMIVHSDLAVHFPAIQYAVLYTLYSHCTRHDHFISSSLSSSSPSLFDGAVISTVTTATKKHFSII 710

  Fly   122 ---VG-----DNANLEVAE---TWA-------------------------CPPPQA-TDDEDISE 149
               :|     ||.|.:..:   |||                         |....| |..||:: 
Human   711 LNLLGILLKKDNLNQDTRKLLMTWALEAAVLMKKSETYAPLFSLPSFHKFCKGLLANTLVEDVN- 774

  Fly   150 HSTAACTSTSSSSEHSNST----------------VVHSPTVGESTCDSVSVSVSHPSPSVSQNN 198
                .|....||....:|:                :|||.|........:..|:  |...|..||
Human   775 ----ICLQACSSLHALSSSLPDDLLQRCVDVCRVQLVHSGTRIRQAFGKLLKSI--PLDVVLSNN 833

  Fly   199 TSSATGRMS---SPHSQSSLSIACEPHSASTTTLSSL-------GSD------------LGNGNG 241
            ..:....:|   ..|...:.|....|...|......|       |.|            |...:.
Human   834 NHTEIQEISLALRSHMSKAPSNTFHPQDFSDVISFILYGNSHRTGKDNWLERLFYSCQRLDKRDQ 898

  Fly   242 STVPAFLM-------------AAPVTL------PIGGQMPTIKCLPG--ASSAASTPKHSRYSKP 285
            ||:|..|:             ||..|:      |:|....|.:.:.|  .|.||.|      ..|
Human   899 STIPRNLLKTDAVLWQWAIWEAAQFTVLSKLRTPLGRAQDTFQTIEGIIRSLAAHT------LNP 957

  Fly   286 RLSLSRVFNHSMPSVHGRPNLSL----------------APAGVPGSV-NPPKRISTH------- 326
            ...:|:.........||...|.|                |..|...:: :|||.|.|.       
Human   958 DQDVSQWTTADNDEGHGNNQLRLVLLLQYLENLEKLMYNAYEGCANALTSPPKVIRTFFYTNRQT 1022

  Fly   327 ----QRNLSLDFRSMGILLPPVSQVTNNH-------INHTQHHRNRSLDSALQRIPEV--EVSSP 378
                ...:.|....:| ||.....||..|       :..|...:...|:..:..:.|.  |:..|
Human  1023 CQDWLTRIRLSIMRVG-LLAGQPAVTVRHGFDLLTEMKTTSLSQGNELEVTIMMVVEALCELHCP 1086

  Fly   379 NAESENTFCSPSILGATM--CSKIATTA------ATVTSALSPPGTPTPALMSTACTPTIGAVKG 435
            .|.......|.||:|..:  .:.:|..|      |:|            ......|..|      
Human  1087 EAIQGIAVWSSSIVGKNLLWINSVAQQAEGRFEKASV------------EYQEHLCAMT------ 1133

  Fly   436 NVQHPVPKHEQSI-SLAAACRSSAVVESCPTLRMRPKSSESVAANGQEMIGVIVSSTGNGSSSSN 499
            .|...:...::|: :||.|.|:||    .|...:..:|.::|.:...:....:::..||.:....
Human  1134 GVDCCISSFDKSVLTLANAGRNSA----SPKHSLNGESRKTVLSKPTDSSPEVINYLGNKACECY 1194

  Fly   500 NSCSSAGSTKKRED-LTSLGSDDSGIICGSESDQISLNRICHSHESLDSGEMDADADAEEECVDL 563
            .|.:...:.::.:: :..|....|......::|   .|.| .|..|.:||:.       .||.:.
Human  1195 ISIADWAAVQEWQNAIHDLKKSTSSTSLNLKAD---FNYI-KSLSSFESGKF-------VECTEQ 1248

  Fly   564 MDTTSIDEEYNIMQPDHLCLYPPQAASTELDCRTLRPSRKQKRQQQQVLERKNLPSQNQIESEDS 628
            ::... .|..|::         ...:..::|.:.|.|               |:.|.:..|.:.|
Human  1249 LELLP-GENINLL---------AGGSKEKIDMKKLLP---------------NMLSPDPRELQKS 1288

  Fly   629 VDAGVDARTRYRVMNMSQAAINVELGTASNEIDPDVNYRE---------SHQDPIADAP-SLSTP 683
            ::.        :::..|     |.|.||.|.|:.|..::.         .....||..| .|||.
Human  1289 IEV--------QLLRSS-----VCLATALNPIEQDQKWQSITENVVKYLKQTSRIAIGPLRLSTL 1340

  Fly   684 SVASTASATPSVTPTPIATPTPTESTKNDQV--------LFKNFFGATKNAIFRTAQSIIE--NH 738
            :|   :.:.|.::...:...:..|:|.::::        ||.....:.|....|.....:.  .:
Human  1341 TV---SQSLPVLSTLQLYCSSALENTVSNRLSTEDCLIPLFSEALRSCKQHDVRPWMQALRYTMY 1402

  Fly   739 EKKNAAKQKEQPDHSGTVSLVGSPNGGSSVPQDLVKSPTDISKKKEFFS----LLTSSSSIKAAA 799
            :.:...|.|||     ||.:       .|...:|..:....::|:...|    ||...|.::...
Human  1403 QNQLLEKIKEQ-----TVPI-------RSHLMELGLTAAKFARKRGNVSLATRLLAQCSEVQLGK 1455

  Fly   800 AAAANSAASTPPATPTEALAANSNSKLQPLSDPSADLKVKERTLNLRLPGDSEG-----SEGALT 859
            ...|...........|:       .::.....|..|:   |:|..|...|.|..     |..|::
Human  1456 TTTAQDLVQHFKKLSTQ-------GQVDEKWGPELDI---EKTKLLYTAGQSTHAMEMLSSCAIS 1510

  Fly   860 KCSSINSIHKLKLPVPGVVKYFISEKAPVSDVLQKPEKGQ------------SGLLRFFESPVFN 912
            .|.|:.:.:.:...:..:.|:..:|...:|..|::..:.|            ..:|...|.|..|
Human  1511 FCKSVKAEYAVAKSILTLAKWIQAEWKEISGQLKQVYRAQHQQNFTGLSTLSKNILTLIELPSVN 1575

  Fly   913 --------------IHFAV----------HYLFYSKEPGVLSF----------IGNKIFSFPDQ- 942
                          :|..|          ::|...:.|.|...          .|.|:.....| 
Human  1576 TMEEEYPRIESESTVHIGVGEPDFILGQLYHLSSVQAPEVAKSWAALASWAYRWGRKVVDNASQG 1640

  Fly   943 -----------EVDLYIPQLVV------MYIQMDEL----AEVLDPYLTIRCRKSVD-------- 978
                       ||...:|..:.      :|..:.:.    |.:.|..:|::..:|.|        
Human  1641 EGVRLLPREKSEVQNLLPDTITEEEKERIYGILGQAVCRPAGIQDEDITLQITESEDNEEDDMVD 1705

  Fly   979 -----FSLKCLWL-----------LEAYNYQVDSLGNSHNSSRKSKLALMKEIFSKREHKQTQND 1027
                 ....|.||           ::.:...||.:.:.:..|..:....:|              
Human  1706 VIWRQLISSCPWLSELDESATEGVIKVWRKVVDRIFSLYKLSCSAYFTFLK-------------- 1756

  Fly  1028 LKSAGTGGLHVGEPRSVVALAKKTHHRSQS-DATVLLADFRSPHTLSISH----RMYQQPPYTTQ 1087
             .:||...|...:||     ...:|...|| |..:::|..|....| :.|    |.|.:  :..:
Human  1757 -LNAGQIPLDEDDPR-----LHLSHRVEQSTDDMIVMATLRLLRLL-VKHAGELRQYLE--HGLE 1812

  Fly  1088 TLPTTPAK------------------------LC---------------LGDLT-------SGHA 1106
            |.||.|.:                        ||               :|.::       ||:.
Human  1813 TTPTAPWRGIIPQLFSRLNHPEVYVRQSICNLLCRVAQDSPHLILYPAIVGTISLSSESQASGNK 1877

  Fly  1107 FDNGCTCFETVRGQVNG---LLGQRTLCSCGAPKTS--PQKEFMKALMNVGK--------NLTSW 1158
            |.   |...|:.|.:.|   |:.:   |..|:|..|  ..|:..|:.:|..:        .:...
Human  1878 FS---TAIPTLLGNIQGEELLVSE---CEGGSPPASQDSNKDEPKSGLNEDQAMMQDCYSKIVDK 1936

  Fly  1159 PSKAEKTSALRMSLNLINKNLPARVWLPLY---------------SDIPHHVVRI-------TEE 1201
            .|.|..|..|::.:.:........:|..|:               ..:...|.|:       .||
Human  1937 LSSANPTMVLQVQMLVAELRRVTVLWDELWLGVLLQQHMYVLRRIQQLEDEVKRVQNNNTLRKEE 2001

  Fly  1202 KTAVLNSKDKT---PYIIYVEVVEIPDIYTSPLIPKMMPSLRHTK-SEEHLDGSCLNSHQHLSCS 1262
            |.|::..|...   |.:..:|  .:..|..:|      ....|.| .:::...:..|:.:.|.  
Human  2002 KIAIMREKHTALMKPIVFALE--HVRSITAAP------AETPHEKWFQDNYGDAIENALEKLK-- 2056

  Fly  1263 RTSSCSSSQQGTSC------------RRKKGADVDGGCGDAGPHNSCSNVHSLGGLQFQEDDVW- 1314
              :..:.::.|:|.            |.:|.|...                    |:.:|...| 
Human  2057 --TPLNPAKPGSSWIPFKEIMLSLQQRAQKRASYI--------------------LRLEEISPWL 2099

  Fly  1315 -SQEEDEITAQYLNMRKVSERDTISQISLDS----------------CDSRDQGPPVVF-NIGDV 1361
             :....||...    .:||.|||::..|:..                ..|..:..|.:| .:.|:
Human  2100 AAMTNTEIALP----GEVSARDTVTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDL 2160

  Fly  1362 RL--RHCSNLSCENTKSFSNDPEDPSAAALKEPWHEKEKLIRESSPYGHLSNWRLL-----SAIV 1419
            .|  |....||..|| .|:.                   :.|:.:|..|..::.:.     |.::
Human  2161 HLDERIMQFLSIVNT-MFAT-------------------INRQETPRFHARHYSVTPLGTRSGLI 2205

  Fly  1420 KCGDDLRQELMATQLLQMFKIIWQEEQV--------DLWVRPYKIVCLSNDSGL----IEPILNT 1472
            :..|.      ||.|..::| .||:.:.        |.:..|.....:...|.|    |.|.|.|
Human  2206 QWVDG------ATPLFGLYK-RWQQREAALQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKT 2263

  Fly  1473 VS-----------LHQIK---------KNSNKSLKEYFIDEYGSPSGESFRRAQKNFVQSCAAYC 1517
            |.           ||.:|         ...|...||.:   ....:.:.:.|..:::.:|.|...
Human  2264 VGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELW---SSCTTPDEWWRVTQSYARSTAVMS 2325

  Fly  1518 LISYLLQVKDRHNGNILFH-SDGHIIHIDFG-------------------FI--------LSISP 1554
            ::.|::.:.|||..|:|.. :.|.::|||:.                   |:        ||...
Human  2326 MVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGNIKVDFTFMRAKCFLVKGQKYNDLSFQG 2390

  Fly  1555 KNLGF-EQSPFKLTPEFVEVMGGTSSE 1580
            |:|.. |:.||::|......:|.|..|
Human  2391 KSLRVPEKVPFRMTQNIETALGVTGVE 2417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fwdNP_001356971.1 PI4Kc_III_beta 1385..1674 CDD:270712 51/262 (19%)
SMG1XP_005255239.1 SMG1 631..1242 CDD:292413 121/650 (19%)
PIKKc_SMG1 2121..2454 CDD:270714 63/327 (19%)
FATC 3659..3688 CDD:280430
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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