DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fwd and Prkdc

DIOPT Version :9

Sequence 1:	NP_001356971.1	Gene:	fwd / 45374	FlyBaseID:	FBgn0004373	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_035289.2	Gene:	Prkdc / 19090	MGIID:	104779	Length:	4128	Species:	Mus musculus

Alignment Length:	1454	Identity:	259/1454 - (17%)
Similarity:	442/1454 - (30%)	Gaps:	560/1454 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   554 ADAEEECVDLMDTTSIDEEYNIMQPDHLCLYPPQAASTELDCRTLRPSRKQKRQQQQV-----LE 613
            |..|....|.:..:|||     :..|| .::..:..|:.|.....|..:.|:...:.|     .:
Mouse  2645 ASVERSSFDWLTGSSID-----LLADH-TVFSSETLSSSLLFSHKRTEKSQRMSCKSVGPDFGTK 2703

  Fly   614 RKNLPS---QNQIESEDSVDAGVDARTRYRVMNMSQ--AAINVELGTASNEIDPDVN-------- 665
            :..||.   .||::|.....|.: .|.|.|.:...:  :.:..:.|....:::.|:.
Mouse  2704 KLGLPDDEVDNQVKSGTPSQADI-LRLRRRFLKDREKLSLLYAKRGLMEQKLEKDIKSEFKMKQD 2767

  Fly   666 -----YRESHQDPIADAPSLSTPSVASTASATPSVTPTPIATPTPTESTKNDQVLFKNFFGATKN 725
                 ||....   .|.|.:             .:..:.:.||....:.| |.::.|..|.:..:
Mouse  2768 AQVVLYRSYRH---GDLPDI-------------QIQHSGLITPLQAVAQK-DPIIAKQLFSSLFS 2815

  Fly   726 AIFRTAQSIIENHEKKNAAKQK----------------------------EQPD---------HS 753
            .|.:.... .:...:||...|.                            :.||         ..
Mouse  2816 GILKEMNK-FKTTSEKNIITQNLLQDFNRFLNTTFLFFPPFVSCIQEISCQHPDFLTLDPASVRV 2879

  Fly   754 GTVSLVGSPNGGSSVPQDLVK----------------SPTDISKKKEFFSLLTSSSSIKAAAAAA 802
            |.::.:..|.|...:.:.|::                .|.|:.:..|...|..|...........
Mouse  2880 GCLASLQQPGGIRLLEEALLRLMPKEPPTKRVRGKTCLPPDVLRWMELAKLYRSIGEYDVLRGIF 2944

  Fly   803 ANSAASTPPATPTEALAANSNSKLQPLSDPSADLKVKERTLNLRLPGDSEGSEG----------- 856
            ::...:|...  ..||.|.:.      ||.....|:.:..||.....|.|.:|.
Mouse  2945 SSELGTTQDT--QNALLAEAR------SDYCQAAKLYDEALNKLEWVDGEPTEAEKEFWELASLD 3001

  Fly   857 ---------ALTKCSSINSIHKLKLPVPGV----------VKYFISEKAPVSDVLQKPEKGQSGL 902
                     .|..||::|.:.:..|.:..:          :.|.|..|..:  :||  .:|...|
Mouse  3002 CYNNLSKWKELEYCSTVNIVSENSLDLSKMWSEPFYQETYLPYVIRSKLKL--LLQ--GEGNQSL 3062

  Fly   903 LRFFESPV-FNIHFAVHYLFYSKEPGVLSFI-------------GNKIF--SFPDQEVDLY---- 947
            |.|.:..: ..:...|..|.||:|..:|..:             |.:||  ::...:|.||
Mouse  3063 LTFVDEAMNKELQKTVLELQYSQELSLLYILQDDIDRATYYIKNGIQIFMQNYSSIDVLLYRSRL 3127

  Fly   948 -----------------------------------------IPQLVV------------------ 953
                                                     .|.:|.
Mouse  3128 AKLQSVQTLAEIEEFLSFICKHGDLSSLGPLRRLLKTWTSRYPDVVTDPMHIWDDIITNRCFFLS 3192

  Fly   954 --------------MYIQMDELA---EVLDPYLTIRCR-KSVDFSLK-----CLWLLEAYNYQVD 995
                          |.:..||.:   ||.:|...:||. :|..|::|     ..|....::..:.
Mouse  3193 KIEERLTAPSGDHSMSVDEDEESIDREVYEPKEDVRCMLQSCRFTMKMKMIESAWKQSNFSLSMK 3257

  Fly   996 SLGNSHNSSRKSKLALMKEIFSKREHKQTQ-NDLKSAGTGGLHVGEPRSVVALAKKT-------- 1051
            .|...|..|:..::..::.:     |..:| |..:|      |...||..|....||
Mouse  3258 LLKEMHKESKTREIWRVQWL-----HSYSQLNHCRS------HTQSPREQVLNMLKTITLLDESD 3311

  Fly  1052 -------HHRSQSDATVLLADFRSPHTLSISHRMYQQPPYTTQTLPTTPAKLCLGDL-------- 1101
                   :.::..|.::||..     |..|          ....|...||  ||.||
Mouse  3312 ISNYLNKNIQASCDQSILLGT-----TCRI----------MADALSREPA--CLSDLEENKVNSI 3359

  Fly  1102 --TSGHAFDNGCTCFETVRGQVNGL--------------LGQRTLCSC----------------- 1133
              .||...:|    .|||   :.||              ..:.|..||
Mouse  3360 LTLSGSNAEN----TETV---ITGLYQRAFHHLSKAVQSAEEETQLSCWGHEAAAERAHAYMTLV 3417

  Fly  1134 -------------GAPKTSPQKEFMKALMNVGK-----NLTSWPSKAEKTSALRM-------SLN 1173
                         .:.|||.:.|...||: |.|     .|.|..::.:....|::       :||
Mouse  3418 GFCDQQLRKVEESASQKTSAEMEAYPALV-VEKMLRALKLNSSEARLKFPRLLQIIEQYSEETLN 3481

  Fly  1174 LINKNLPARVWLPLYSDIP--HHVVRITEEKTAVLNSKDKTPYIIYVEVVEIPDIYTSPLIPKMM 1236
            ::.|.:.:   :|.:..|.  .|::.:.:::.|:         .:...|.||.|.|...:|...:
Mouse  3482 IMTKEISS---IPCWQFIGWISHMMALLDKEEAI---------AVQHTVEEIADNYPQAIIYPFI 3534

  Fly  1237 PSLRHTKSEEHLDGSCLNSHQHLSCSRTSSCSSSQQGTSCRRKKGADVDGGCGDAGPHNSCSNVH 1301
            .|     ||.:            |...|||..:::......:.|   :|.|          ..:|
Mouse  3535 IS-----SESY------------SFKNTSSGHNNKAFVERIKSK---LDHG----------EVIH 3569

  Fly  1302 S-LGGL-QFQEDDV----W-SQEEDEITAQYLNMRKVSERDTISQISLDSCDSRDQGPPVVFNIG 1359
            | :..| |....|:    | |..:||:....:|.:.:.:.......:|.  |.|..|      :|
Mouse  3570 SFINALDQLSNPDLLFKDWVSDTKDELGKNPVNKKNIEKLYERMYAALG--DLRAPG------LG 3626

  Fly  1360 DVRLRHCSNLSCENTKSFSN--------------------------DPEDPSAAALKEPWHE--K 1396
            ..|.|.......|..|||.|                          |.:.|.......||..  |
Mouse  3627 PFRRRFIQAFGKEFVKSFGNGGSKLLTMKVDDFCKITGSLLVRMKKDSKLPGNLKEYSPWMSEFK 3691

  Fly  1397 EKLIR-----------ESSPY-----------------------------GHLSNWRLLSAIVKC 1421
            .:.::           :|.|.                             ||  :.:....:||.
Mouse  3692 AQFLKNELEIPGQYDGKSKPLPEYHVRISGFDERVKVMLSLRKPKRIVIRGH--DEKEYPFLVKG 3754

  Fly  1422 GDDLRQELMATQLLQMFKIIWQEE----QVDLWVRPYKIVCLSNDSGLIEPILNTVSLHQ----- 1477
            |:||||:....|:.::...|..::    |.::.:|.|::|.:::..||||.|.||::|..
Mouse  3755 GEDLRQDQRIEQIFEVMNAILSQDAACSQRNMQLRTYRVVPMTSRLGLIEWIENTMTLKDLLLSN 3819

  Fly  1478 -----------------------IKKNSNKS--------------------------------LK 1487
                                   :.|.|.||                                ||
Mouse  3820 MSQEEKVANNSDPKAPIRDYKDWLMKVSGKSDAGAYVLMYSRANRTETVVAFRRRESQVPPDLLK 3884

  Fly  1488 EYFIDEYGSPSGESFRRAQKNFVQSCAAYCLISYLLQVKDRHNGNILFHSD-GHIIHIDFGFILS 1551
            ..|:....||  |:|...:.:|..|.|..|:..:||.:.|||..|.:...: |.:|.||||....
Mouse  3885 RAFVKMSTSP--EAFLALRSHFASSHALLCISHWLLGIGDRHLNNFMVAMETGSVIGIDFGHAFG 3947

  Fly  1552 ISPKNLGF-EQSPFKLTPEFVEVM 1574
            .:.:.|.. |..||:||.:||.:|
Mouse  3948 SATQFLPVPELMPFRLTRQFVSLM 3971

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	64/298 (21%)
Prkdc	NP_035289.2	HEAT 1	288..323
		HEAT 2	1001..1037
		HEAT 3	1050..1086
		Interaction with C1D. /evidence=ECO:0000250	1501..1536
		Leucine-zipper	1501..1536
		TPR 1	1720..1753
		ArAE_1_C	<1766..1822	CDD:288564
		NUC194	1812..2198	CDD:285387
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2049..2071
		KIP-binding. /evidence=ECO:0000250	2432..3213		90/604 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2614..2635
		FAT	3024..3470	CDD:280429	82/485 (17%)
		PIKKc_DNA-PK	3719..4014	CDD:270716	59/257 (23%)
		FATC	4097..4128	CDD:280430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900