DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fwd and Pik3cd

DIOPT Version :9

Sequence 1:	NP_001356971.1	Gene:	fwd / 45374	FlyBaseID:	FBgn0004373	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	XP_006538704.1	Gene:	Pik3cd / 18707	MGIID:	1098211	Length:	1074	Species:	Mus musculus

Alignment Length:	977	Identity:	203/977 - (20%)
Similarity:	351/977 - (35%)	Gaps:	301/977 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   789 LTSSSSIKAAAAAAANSA------ASTPPATPTEALAANSNSKLQPLSDPSADLKVKERTLN--- 844
            :..||||.|.....:|.|      .:.||..|.:   ..|:..|..|..|.:...::.|.:|
Mouse   276 MVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAK---KPSSVSLWSLEQPFSIELIEGRKVNADE 337

  Fly   845 -LRL---PGDSEGSEGALTKCSSINSIHKLKLPV--------------PGVVK-----YFISEKA 886
             ::|   .|...|:| .|.|..|.:.::....||              |.:.:     |.:.|||
Mouse   338 RMKLVVQAGLFHGNE-MLCKTVSSSEVNVCSEPVWKQRLEFDISVCDLPRMARLCFALYAVVEKA 401

  Fly   887 PVSDVLQKPEKGQSGLLRFFESPVFNIHFAVHYLFYSKEPGVLSFIGNKIFSFPDQ----EVDLY 947
            ..:...:|..|                          |....:::....:|.:.||    |..||
Mouse   402 KKARSTKKKSK--------------------------KADCPIAWANLMLFDYKDQLKTGERCLY 440

  Fly   948 I-PQLVVMYIQMDELAEVLDPYLTIRCRKSVDFSLKCLWLLEAYNYQVDSLGNSHNSSRKSKLAL 1011
            : |.:      .||..|:|:|..|:|                         ||.:..|..:.:..
Mouse   441 MWPSV------PDEKGELLNPAGTVR-------------------------GNPNTESAAALVIY 474

  Fly  1012 MKEI------------------------FSKREHKQTQNDLKSAGTGGLHVGEPRSVVALAKKTH 1052
            :.|:                        .::.|..|.:..|:..|:|.|:..|.    .|..|..
Mouse   475 LPEVAPHPVYFPALEKILELGRHGERGRITEEEQLQLREILERRGSGELYEHEK----DLVWKMR 535

  Fly  1053 HRSQSDATVLLADFRSPHTLSISHRMYQQPPYTTQTLPTTPAKLCLGDLTSGHAFDNGCTCFETV 1117
            |..|                              :..|...|:|.|....:.|         |.|
Mouse   536 HEVQ------------------------------EHFPEALARLLLVTKWNKH---------EDV 561

  Fly  1118 RGQVN--GLLGQRTLCSCGAPK---TSPQKEFMKA-LMNVGKNLTSWPSKAEKTSALRMSLNLIN 1176
             .||:  |..|::       |:   |.|...::.. |..:...|.|||.     ..:..:|.|::
Mouse   562 -AQVSREGGSGRQ-------PRGRWTVPAHPYLTTKLSQMLYLLCSWPE-----LPVLSALELLD 613

  Fly  1177 KNLPARVWLPLYSDIPHHVVRITEEKTAVLNSKDKTPYIIYVEVVEIPDIY-----TSPLIPKMM 1236
            .:.|           ..:|.....:....|...:...|::.:..|...:.|     |..|:.:.:
Mouse   614 FSFP-----------DCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLGRAL 667

  Fly  1237 PSLR-------HTKSEEH-----------LDGSCLNSHQHLSCSRTSSCSSSQQGTSCRRKKGAD 1283
            .:.:       |.:||.|           ::..|..|..|:..       ..:||.:..:.|..
Mouse   668 ANRKIGHFLFWHLRSEMHVPSVALRFGLIMEAYCRGSTHHMKV-------LMKQGEALSKLKAL- 724

  Fly  1284 VDGGCGDAGPHNSCSNVHSLGGLQFQEDDVWSQEEDEITAQYLNMRKVSERDTIS--QISLDSCD 1346
                       |....|.|....:.|..::          .::.||:.:..:.:|  |..||
Mouse   725 -----------NDFVKVSSQKTTKPQTKEM----------MHMCMRQETYMEALSHLQSPLD--- 765

  Fly  1347 SRDQGPPVVFNIGDVRLRHCSNLSCENTKSFSNDPEDPSAAALKEPWHEKEKLIRESSPYGHLSN 1411
                 |..:..      ..||...|    :|.:       :.:|..|     ::..|...|...|
Mouse   766 -----PSTLLE------EVCSVEQC----TFMD-------SKMKPLW-----IMYSSEEAGSAGN 803

  Fly  1412 WRLLSAIVKCGDDLRQELMATQLLQMFKIIWQEEQVDLWVRPYKIVCLSNDSGLIEPILNTVSLH 1476
               :..|.|.||||||:::..|::|:..::|::|.:||.:.||..:...:.:||||.:|::.::.
Mouse   804 ---VGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIA 865

  Fly  1477 QIKKN-SNKSL-----KEYFIDEYGSPS-GESFRRAQKNFVQSCAAYCLISYLLQVKDRHNGNIL 1534
            .|:.| ||.:.     |:..::...|.: ||:..||.:.|..|||.||:.:|:|.:.|||:.||:
Mouse   866 NIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIM 930

  Fly  1535 FHSDGHIIHIDFGFILSISPKNLGF--EQSPFKLTPEFVEVM--GGT-SSEHWREFNKLLLVGMM 1594
            ....|.:.|||||..|.......|.  |:.||.||.:||.|:  |.| :||.:..|.........
Mouse   931 IRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYT 995

  Fly  1595 SARKHMDRIINFVEIMRSNAHLPCFKNGCSGTVQNLRKRFHMNLTEQEMER----KVEQLVQDSL 1655
            ..|:|....::...:||: |.||  :..||..:|.|:....:..||:|..:    |..:.:::|.
Mouse   996 ILRRHGLLFLHLFALMRA-AGLP--ELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESW 1057

  Fly  1656 KS 1657
            |:
Mouse  1058 KT 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	87/289 (30%)
Pik3cd	XP_006538704.1	PI3K_p85B	32..107	CDD:396665
		PI3K_rbd	182..281	CDD:395642	1/4 (25%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	40/224 (18%)
		PI3Ka	504..713	CDD:214537	47/282 (17%)
		PI3Kc_IA_delta	705..1072	CDD:270718	106/420 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900