Protein Alignment fwd and Pik3ca

DIOPT Version :9

• Sequence 1: NP_001356971.1
• Gene: fwd / 45374
• FlyBaseID: FBgn0004373
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: NP_032865.2
• Gene: Pik3ca / 18706
• MGIID: 1206581
• Length: 1068
• Species: Mus musculus
• Alignment Length: 594
• Identity: 135/594 - (22%)
• Similarity: 237/594 - (39%)
• Gaps: 170/594 - (28%)

  Fly  1128 RTLCSCG--APKTSPQKEFM---------------KALMNVGKN-----------LTSWPS-KAE 1163
            |.||:..  :..|..:|:|:               |.|::|..|           :..||. |.|
Mouse   532 RALCTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPE 596

  Fly  1164 KTSALRMSLNLINKNLPARVWLPLYSDIPHHVVRITEEKTAVLNSKDKTPYII-YVEVVE----I 1223
            :      ::.|::.|.|.    |:   :....||..|:   .|.....:.|:| .|:|::    :
Mouse   597 Q------AMELLDCNYPD----PM---VRSFAVRCLEK---YLTDDKLSQYLIQLVQVLKYEQYL 645

  Fly  1224 PDIYTSPLIPKMMPSLR-------HTKSEEHLDGSCLNSHQHLSCSRTSSCSSSQQGTSCRRKKG 1281
            .::....|:.|.:.:.|       |.|||.|              ::|.|           ::.|
Mouse   646 DNLLVRFLLKKALTNQRIGHFFFWHLKSEMH--------------NKTVS-----------QRFG 685

  Fly  1282 ADVDGGCGDAGPHNSCSN--VHSLGGLQFQEDDVWSQEEDEITAQYLNMRKVSERDTISQISLDS 1344
            ..::..|...|.:....|  |.::..| ....|:..||:.:.|      :||..:..:.|:....
Mouse   686 LLLESYCRACGMYLKHLNRQVEAMEKL-INLTDILKQEKKDET------QKVQMKFLVEQMRQPD 743

  Fly  1345 CDSRDQG--PPV--VFNIGDVRLRHCSNLSCENTKSFSNDPEDPSAAALKEPWHEKE---KLIRE 1402
            .....||  .|:  ...:|::||..|..:|......:.|             |...:   :|:.:
Mouse   744 FMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLN-------------WENPDIMSELLFQ 795

  Fly  1403 SSPYGHLSNWRLLSAIVKCGDDLRQELMATQLLQMFKIIWQEEQVDLWVRPYKIVCLSNDSGLIE 1467
            ::           ..|.|.||||||:::..|::::.:.|||.:.:||.:.||..:.:.:..||||
Mouse   796 NN-----------EIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIE 849

  Fly  1468 PI--------------------LNTVSLHQIKKNSNKSLKEYFIDEYGSPSGESFRRAQKNFVQS 1512
            .:                    .|:.:|||..|:.||              ||.:..|...|.:|
Mouse   850 VVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNK--------------GEIYDAAIDLFTRS 900

  Fly  1513 CAAYCLISYLLQVKDRHNGNILFHSDGHIIHIDFGFILSISPKNLGF--EQSPFKLTPEFVEVMG 1575
            ||.||:.:::|.:.||||.||:...||.:.|||||..|....|..|:  |:.||.||.:|:.|:.
Mouse   901 CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVIS 965

  Fly  1576 G-----TSSEHWREFNKLLLVGMMSARKHMDRIINFVEIMRSNA--HLPCFKNGCSGTVQNLRKR 1633
            .     |.:..:..|.::.....::.|:|.:..||...:|..:.  .|..|.:     :..:||.
Mouse   966 KGAQEYTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDD-----IAYIRKT 1025

  Fly  1634 FHMNLTEQE 1642
            ..::.||||
Mouse  1026 LALDKTEQE 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	77/290 (27%)
Pik3ca	NP_032865.2	PI3K_p85B	32..107	CDD:366969
		PI3K_rbd	173..292	CDD:366310
		C2_PI3K_class_I_alpha	325..484	CDD:176043
		PI3Ka_I	525..696	CDD:238444	38/204 (19%)
		PI3Kc_IA_alpha	695..1064	CDD:270719	97/390 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910