Protein Alignment fwd and Y75B8A.24

DIOPT Version :9

• Sequence 1: NP_001356971.1
• Gene: fwd / 45374
• FlyBaseID: FBgn0004373
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: NP_499596.2
• Gene: Y75B8A.24 / 176653
• WormBaseID: WBGene00013557
• Length: 2106
• Species: Caenorhabditis elegans
• Alignment Length: 2041
• Identity: 408/2041 - (19%)
• Similarity: 709/2041 - (34%)
• Gaps: 639/2041 - (31%)

  Fly     3 SVISAFKGKKNSNPSCNSPMGSANGTAPVEAKPNNCYQYLRHIREIDTNNK-LLSPVVVVAEERP 66
            ||.::.|.::|    |.:.:..|:.::|:..|         ..:||...:| .||.:........
 Worm   333 SVKNSDKNQEN----CGNSLQEASPSSPISEK---------FAKEISIFSKTALSKLDAELSSLQ 384

  Fly    67 VSKAGSPST----------VATMA------TGVDVVDH---CLPTTVRLSVTEA----LSDLNMN 108
            .|...|.||          .||:.      ..:|.:|.   |....|||...:.    :|.|.:.
 Worm   385 HSSESSLSTEVSRQKLNIQSATVCLQLIAWAAIDDMDADAICTEIIVRLFANQTQKTIISQLPLY 449

  Fly   109 GKAVEP--------PVTPCTSVGDNANLEVAETWACPPPQ----ATDDE--------DISEHSTA 153
            .||:..        |....|:|..|....:.|    |.|.    |:|..        |:.:||.:
 Worm   450 LKAISSMATLAEKFPAVATTAVIQNLQRFLLE----PAPMLTKLASDSTLERGKSAGDVIQHSKS 510

  Fly   154 ------ACTSTSSSSEHSNSTVVHSPTVGESTCDSVSVSVSHPSPSVSQNNTSSATGR-MSSPHS 211
                  |.|....|.:...::.:      ::.|.::..|:...|.||.|.....:|.. :.|..:
 Worm   511 SNNLIDAITKRKLSLDALRNSAI------KAICRALKSSIRMESDSVQQCLAGLSTKLFVCSNAN 569

  Fly   212 QSSLSIACEPHSASTTTLSSLGSDLGNGNGSTVPAFLM-------AAPVTLPIGGQMPTIKCLPG 269
            ...:|:.||   .:..||..:|..|.:.....||..::       |.|   |....:..|:||..
 Worm   570 NFVVSLVCE---NAIQTLGGIGVGLVDSTAVEVPEMVVQIYLQRFANP---PSQLDVTMIRCLAE 628

  Fly   270 ASSAASTPKHSRYSKPRLSLSRVFNHSMPSVHGRPNLSLAPAGVPGSVNPPKRISTHQRNLSLDF 334
            ...|.:   .|.|.......:::...|...|:
 Worm   629 MWIAGA---RSIYENVWKLFTQICIESSNRVY--------------------------------- 657

  Fly   335 RSMGILLPPVSQVTNNHINHTQH-HRNRSLDSALQRIPEVEVSSPNAESENT--------FCSPS 390
             |.|          ||..|..:: |.:.::|.|:.|   :.....|.:.:.|        |....
 Worm   658 -SQG----------NNESNDQRYTHVSLAVDVAMSR---MAAGVANEDDKMTLLVRLLELFVQLG 708

  Fly   391 ILGATMCSKIATTAATVTSALSPPGTPTPALMSTACTPTIGAVKGNVQHPVPKHEQSISLAAACR 455
            |.|..:..|::.:...               |||:.        ||:...:||      :|:..|
 Worm   709 IEGRRVGEKVSKSTVK---------------MSTSA--------GNLGVLMPK------IASLLR 744

  Fly   456 SSAVVESCPTLRMRPKSSESVAANGQ--------EMIGVIVSSTGNGSSSSNNS-CSSAGSTK-- 509
                       ||:|.|..:......        .::|..|.|:........|: |.:|..|.
 Worm   745 -----------RMQPISEPTTKLRSLFRDFWFYCTVLGFDVESSSLWPEEWYNAVCETATKTPVL 798

  Fly   510 -KREDLTSLGSDDSGIICGSESDQISLNRICHSHESLDSGEMDADADAEEECVDLMDTTSIDEEY 573
             ..|:|.|                          |.:|:..:.:|:.:.:|..::.:|.
 Worm   799 IATENLRS--------------------------ELIDNAAIRSDSISPQELQEMRNTV------ 831

  Fly   574 NIMQPDHLCLYPPQAASTEL-------DCRTLRPSRKQKRQQQQVLERKNLPSQNQIESEDSVDA 631
             :.:..|      ||.:..|       :|..|....:        :|...|...|.:::..|...
 Worm   832 -LAELSH------QAEAVPLINRFDFANCTYLLSVHR--------METMRLIHANHVDAFSSFFK 881

  Fly   632 GVDARTRYRVMN-----MSQAAINVELGTASNEIDPDVNYRESHQDPIADA-------------- 677
            .::.:|..:..:     |..||..:.|     |....:..|..:.:|..:|
 Worm   882 YIEDKTMRKDKSGLWTCMLAAAPRIFL-----EWCEKMMKRRDNDEPTEEALVWHAQFLLFKFNH 941

  Fly   678 -----PSLSTPSVASTASATPSVTPTPIATPTPTESTKNDQVLFKNFFGATKNAIFRTAQSIIEN 737
                 ..::...::....|.|.:             ..|.:||         ..|.|..|.:.:|
 Worm   942 HLREVRKVADACLSQLVKAFPYL-------------LWNTKVL---------TTILRLLQELEDN 984

  Fly   738 HEKKNAAKQKE---QPDHSGTVSLVGSPNGGSSVPQDLVKSPTDISKKK-------------EFF 786
            .:|....::.:   :.....|:.|..|..|..||.:|.......|.|:.             |:.
 Worm   985 LQKDPTCREPQFTIEGFGGWTIQLQDSIEGRRSVVKDFSMRVKQILKEALRWAPASTHSNLLEYV 1049

  Fly   787 SLLTSSSSIKAAAAAAANSAASTPPATPTEALAANSN------SKLQPLSDPSADLKVKERTLNL 845
            |...|........|..|.|..|....:...:|...||      ..|........|....|..|..
 Worm  1050 SKFGSERDAAMQLAIDATSEGSGKSGSYLTSLYKRSNYLGQVKGMLATTLSGDIDQVTAENQLID 1114

  Fly   846 RLPGDSEGSEGALTKCSSINSIHKLKLPVPGVVKYFIS----EKAPVSDVLQKPEKGQSGLLRFF 906
            ||..|.:.:      |.|...: :::..|..:...|:|    .:..:|.:::.|      ||.|.
 Worm  1115 RLEKDFQRA------CKSGKDM-EMEQAVLLLTALFVSLRSLNERILSLLVRTP------LLNFT 1166

  Fly   907 ESPVFNIHFAVHYLFYSKEPGVLSFIGNKIFSFPDQE---VDLYIPQLVVMYIQMDELAEVLDPY 968
            ||.|.....|.::|..::......|:..:..:|.|..   :.|:..::|    ....|.:.|:
 Worm  1167 ESTVSLCTMAWNWLLSARPEAHSLFLHEQARAFADSSRFGLGLFEKEVV----GGSPLCQKLE-- 1225

  Fly   969 LTIRCRKSVDFSLKCLWLLEAYNYQVDSLGN-----SHNSSRKSKLALMKEIFSKREHKQTQNDL 1028
               |...|.:|.....|        ::.:|.     |::|  :.:|.:::.:||     ||.:
 Worm  1226 ---RPPPSANFRPHREW--------IEFIGERCDVASYSS--REQLDVLEMMFS-----QTLS-- 1270

  Fly  1029 KSAGTGGLH----VGEPRSVVALAKKTHHRS----------------------QSDATVLLADFR 1067
            ...|||.||    ...|.|:...::|.....                      |.||.:|
 Worm  1271 AHIGTGHLHGSTACSNPASLAGPSRKETINQVTRGIEAVGVRFRLLSCVLGMVQQDACLL----- 1330

  Fly  1068 SPHTLSISHRMYQQP-PYTT--QTLPTTPAKLCLGDLTSGHAFDNGCTCFETVRGQ--------- 1120
            .|..:.|..|:|... .|.|  ...||.|.:....|:.....|      ||.::..
 Worm  1331 RPTNVLIRQRVYSCAFHYFTIAPQGPTQPEERLREDIRLLTRF------FEHLKNDKHYMQKEAL 1389

  Fly  1121 --------VNGLLGQR---------------TLCSCGAPKTS----PQKEFMKALMNVGKNLTSW 1158
                    ::..:.|.               |..:.|.|.||    |...:...|     .|:|.
 Worm  1390 AKTDKNLVMSSTMSQMQTNFEKSLLISGTPVTATAAGTPNTSLMLPPSTNYANTL-----TLSSQ 1449

  Fly  1159 PSKAEKTSALRMSLNL-----INKNLPARVW--------LPLYSDIPH-----HVVRITEEKTAV 1205
            .|.|..::::|...::     |.::...:.|        |.:.::|..     |.:.:.:|..|
 Worm  1450 KSMAATSASIRSGKSIETKLSIEEDRRIKTWMKQRNMLMLLVANEIERLSAWLHPLALAQEDCA- 1513

  Fly  1206 LNSK----------------------------DKTPYIIYVEVVEIPDIYT-SPLIPKMMPSLRH 1241
            |:|:                            |.:|.:    .:::|..:. ||.:.|.:..|..
 Worm  1514 LDSEEFLRGAFTQAKATGGEKNIWREQAQLAWDISPEL----AIQLPSRFRGSPELVKYVDVLVR 1574

  Fly  1242 TKSE--EHL---------DGSCLNSHQHLS-------CSRTSSCS------------SSQQGTSC 1276
            .:.|  .|:         :||.:.....:|       ||...:.|            |.|.....
 Worm  1575 GQPEPVAHIPEALPLFLGNGSTVFETSDMSHVLTWARCSPVMALSLLTPRIYPMHPISMQYAVRV 1639

  Fly  1277 RRKKGA----------------DVDGGCGD-----AGPHNSCSNVHSLGGLQ---FQEDDVWSQE 1317
            .|...|                |..|...:     || |:...:...:..:|   |.:::  |:.
 Worm  1640 LRSYSADELLLYIPQIVQAVRYDTMGYISELIIWLAG-HSQLLSHQLIWNMQTNMFTDEE--SKV 1701

  Fly  1318 EDEITAQYLN--MRKV-------------SERDTISQISLDSCDSRDQGPPVVFNIGDVRLRHC- 1366
            :|.:..:.||  |:|:             :|.....|::..|      |....|..||.|.:.|
 Worm  1702 KDPVLFEALNDIMQKILSQLEGAARRFHEAEFKLFHQLTAIS------GTIKPFPKGDARKKACL 1760

  Fly  1367 ---SNLSCENTKSFSNDPE-----------DPSAAALKEPW-----------HEKEKL-IRESSP 1405
               :::..|......::||           .|..:|.|.|:           .|.|.: ::..|.
 Worm  1761 KALADVKIETITYLPSNPEAVLLDLDYSSGTPMQSAAKAPFLARFRVKRCGVRELEHIGLQAQSE 1825

  Fly  1406 YGHLSN----------------WRLLSAIVKCGDDLRQELMATQLLQMFKIIWQEEQVDLWVRPY 1454
            :|..:.                |:  :||.|.|||:||:::|.||:|:.|.:|....:.:.|.||
 Worm  1826 HGGKTTEADLEELKKVQDSRVCWQ--AAIFKVGDDVRQDMLALQLMQLMKNVWAGLGLPVRVFPY 1888

  Fly  1455 KIVCLSNDSGLIEPILNTVSLHQIKKNSNKSLKEYFIDEYGSPSGESFRRAQKNFVQSCAAYCLI 1519
            ::|..|...|:||.:.|:.|..|:.:.::..|.|||..:||..|.|:|:.|::|||:|.|||.:.
 Worm  1889 RVVATSPGCGVIECVPNSKSRDQLGRQTDFGLYEYFKTQYGDESSETFQEARRNFVRSMAAYSVF 1953

  Fly  1520 SYLLQVKDRHNGNILFHSDGHIIHIDFGFILSISP-KNLGFEQSPFKLTPEFVEVMGG-TSSEHW 1582
            |:|||:||||||||:...|||||||||||:...|| .|||||.. |||:.|.|.:||| ..:..:
 Worm  1954 SFLLQIKDRHNGNIMIDLDGHIIHIDFGFMFESSPGGNLGFEPD-FKLSEEMVAIMGGKMEAAPF 2017

  Fly  1583 REFNKLLLVGMMSARKHMDRIINFVEIMRSNAHLPCFKNGCSGTVQNLRKRFHMNLTEQEMERKV 1647
            |:|..|.:...::.|.:....::.|.:| .:.|||||:   ..|:..||.||...:.|::..:.:
 Worm  2018 RQFASLCVHAYLAVRPYHKSFVSLVSLM-LDTHLPCFR---GKTINQLRARFAPEMNEKDAAKYM 2078

  Fly  1648 EQLVQDSLKSLSTKLYDGYQYYTNGI 1673
            ..::.:...::.:|:||..||:.|.|
 Worm  2079 YSVITNCFLNIRSKMYDQLQYFQNEI 2104

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	112/319 (35%)
Y75B8A.24	NP_499596.2	PI4Ka	1544..1720	CDD:238443	32/182 (18%)
		PI4Kc_III_alpha	1781..2105	CDD:270711	113/331 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1147978at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820