DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fwd and vps-34

DIOPT Version :9

Sequence 1:	NP_001356971.1	Gene:	fwd / 45374	FlyBaseID:	FBgn0004373	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_491741.1	Gene:	vps-34 / 172280	WormBaseID:	WBGene00006932	Length:	901	Species:	Caenorhabditis elegans

Alignment Length:	399	Identity:	97/399 - (24%)
Similarity:	173/399 - (43%)	Gaps:	59/399 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1298 SNVHSLGGLQ-FQEDDVWSQEEDEITAQYLNMRKVSERDTISQISLDSCDSRDQGPPV--VFNIG 1359
            :.|.||...| |.||.:....|.:.....||..|.:|..|:...:....|.:....|:  .|.:.
Worm   540 AQVDSLHQQQIFVEDLIILMNEAKARGGRLNESKSAEFRTMLSRAKHMLDLKGVHLPLDPSFRLS 604

  Fly  1360 DVRLRHCSNLSCENTKSFSNDPEDPSAAALK--EPWHEKEKLIRESSPYGHLSNWRLLSAIVKCG 1422
            .|         ..:|.||......|:..:.|  :|..:.::.|.|.           .:.|.|.|
Worm   605 SV---------IPDTASFFKSEMMPAKISFKVLQPNGKADRNIPEE-----------YTVIFKTG 649

  Fly  1423 DDLRQELMATQLLQMFKIIWQEEQVDLWVRPYKIVCLSNDSGLIEPILNTVSLHQIKKNSNKSLK 1487
            |||||:.:..|::::..||.::.|:||.:.||.::......|.::         .||....::::
Worm   650 DDLRQDQLIQQMVRLIDIILKKGQLDLKLTPYLVLSTGVGQGFVQ---------CIKSKPLRAIQ 705

  Fly  1488 EYFIDEYGSPSGESFRRAQK-----------------NFVQSCAAYCLISYLLQVKDRHNGNILF 1535
            |    :|.:...:..|.|.|                 |:|:|.|.|.:|.|:|.:.|||..|:|.
Worm   706 E----QYKAHKMDCIREAMKELRPGDGPFGIEPNVIDNYVRSLAGYSVIMYILGLGDRHLDNLLL 766

  Fly  1536 HSDGHIIHIDFGFILSISPKNLGFEQSPFKLTPEFVEVMGGTSSEHWREFNKLLLVGMMSARKHM 1600
            ..:|.:.|:||||||...||.:   ..|.|||.|.|:||||..|:.:.||.:.:.......|:|.
Worm   767 CENGKLFHVDFGFILGRDPKPM---PPPMKLTSEMVQVMGGVKSKQFLEFVQHVDSAYRILRRHS 828

  Fly  1601 DRIINFVEIMRSNAHLPCFKNGCSGTVQNLRKRFHMNLTEQEMERKVEQLVQDSLKSLSTKLYDG 1665
            :.::|...:| .:|.:|.........:..:.:|..::|:::...:.:...::.||.:....:.|.
Worm   829 NVLLNLFSLM-LDAGIPDIAAEPDKAIFKIEQRLRLDLSDEAATKHIFTQIESSLNAKMAMISDI 892

  Fly  1666 YQYYTNGIL 1674
            ...|...::
Worm   893 IHAYKQNLM 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	76/307 (25%)
vps-34	NP_491741.1	C2_PI3K_class_III	21..193	CDD:176042
		PI3Ka_III	303..509	CDD:238442
		PI3Kc_III	543..898	CDD:270628	96/391 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910