Protein Alignment fwd and Pik3c2g

DIOPT Version :9

• Sequence 1: NP_001356971.1
• Gene: fwd / 45374
• FlyBaseID: FBgn0004373
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: NP_446375.1
• Gene: Pik3c2g / 116720
• RGDID: 620231
• Length: 1505
• Species: Rattus norvegicus
• Alignment Length: 1146
• Identity: 234/1146 - (20%)
• Similarity: 407/1146 - (35%)
• Gaps: 317/1146 - (27%)

  Fly   733 SIIENHEKKNAAKQKEQPDHSGTVSLVGS-----PNGGSSV----------PQDLVKSPTDISKK 782
            ||.::.||.:......:|      |||.|     |....::          |.::|::|...:|.
  Rat   185 SIPDSEEKGSGDADLVEP------SLVFSKDSFLPRASENMSVESTEPIGCPLEIVEAPQGSNKS 243

  Fly   783 -KEFFSLLTSSSSIKAAAAAAANS----AASTPPATPTEALA--------ANSNSKLQPLSDPSA 834
             ..|.:.:|....:..|:...:||    |.:|  |.|:...|        :..||....|..|.|
  Rat   244 LASFCNNVTKIRGLYHASDTNSNSGKIWAITT--AYPSRLFADTQFRVKISTDNSAQLLLLKPPA 306

  Fly   835 DLKVKERTLNLRLPGDSE---GSEGALTKCSS---INSIHKLKLPVPGVVKYFISEKAPVSDVLQ 893
            :..||:....:.|...:|   ..|..|:.|.|   :.:.|.|     |..|.|...|:.:...||
  Rat   307 NYLVKDLIAEILLLCANEQLSPKEYLLSICGSEEFLQTDHCL-----GSHKIFQKSKSVIQLHLQ 366

  Fly   894 KPEKGQSGLLRFFESPVFNIHFAVHYLFYSKEPGVLSF-----IGNKIFSFPDQEVDLYIPQLVV 953
            :.......|.|..:.....:|.          ..:|.|     |..:..|...:..:|::..|:.
  Rat   367 RSRDTPGKLSRKRDDDRSRVHL----------NQLLEFTHIWKISRQCLSTVMKSYNLHVEHLLK 421

  Fly   954 MYIQMDE---------------------LAEVLDPYLTIRC--RKSVDFSLKCLWLLEAYNYQVD 995
            ....::|                     :.:|.:....:.|  .|.|..::|.|.|:.....|
  Rat   422 TQEDVEEKPLSSMFSCGRHPPQPHGNDIIEDVRNICSVLGCIETKQVSDAVKELTLILQRPSQ-- 484

  Fly   996 SLGNSHNSSRKSKLALMKEIFSKREHKQTQNDLKSAGTGGLHVGEPRSVVALAKKTHHRSQSDAT 1060
               |.|.:|..||...::.:.|:                            |::..|.......:
  Rat   485 ---NFHQNSETSKKGFIENVTSE----------------------------LSRSLHQLVDVYCS 518

  Fly  1061 VLLADF---RSPHTLSISHR-MYQQPPYTTQTLPTTPAKLCLGDLTSGHAFDN-GCTCFETVRGQ 1120
            ....||   |:|..:|..|. ::....:|..:|...|.       |..|::.. ..:|:.|..|
  Rat   519 SFCTDFRPARAPGGVSRDHAGLHSHLSFTVCSLHNVPE-------TWAHSYKAFSFSCWLTYAG- 575

  Fly  1121 VNGLLGQRTLC---SC-GAPKT--------------------SPQKEFMKALMNVG-------KN 1154
                   :.||   || ..|.|                    |..:|.|..:...|       .|
  Rat   576 -------KKLCQVKSCRSLPVTKSFSFSVNWNEIINFPLEIKSLPRESMLVIKLFGIDSATHSAN 633

  Fly  1155 LTSW------PSKAEKTSALRMSLNL-----INKNLPARVW-------LPLYSDIP--------- 1192
            |.:|      |.:.....:..:|:.|     |....|. ||       |.|..|.|
  Rat   634 LLAWTCLPLFPKEKSPLGSRLLSMTLQSEPPIEMMAPG-VWDGSQPTPLTLQIDFPAATWEYVKP 697

  Fly  1193 -----------------HHVVRITEEKTAVLNSKDKTPYIIYVEVVEIPDIYTSPLIPKMMPSL- 1239
                             .|:.|:::::..:|.|.:|..|:.:.......:..:.||:....|..
  Rat   698 ETEENRTDHQEPPRECLKHIARLSQKQPPLLLSVEKRRYLWFYRFYCNNENSSLPLVLGSAPGWD 762

  Fly  1240 RHTKSEEHLDGSCLN----SHQHLSCSRTSSCSSSQQGTSCRRKKGADVDGGCGD---------- 1290
            ..|.||.|   :.|.    ||...:....:|....|   ..|......:|....|
  Rat   763 EGTVSEMH---AVLRRWTFSHPLEALGLLTSRFPDQ---DIREVAVQQLDNFLTDELLDCLPQLV 821

  Fly  1291 ---------AGP------HNSCSNV---HSLGGL--QFQEDDV---WSQE---EDEITAQYLNMR 1329
                     ..|      |.|..::   |.|..|  ..|.:|.   |.||   ..:..|....:.
  Rat   822 QAVKFEWSLESPLVELLLHRSLQSIRVAHRLFWLLRDAQGEDYFKSWYQELLAALQFCAGEALIE 886

  Fly  1330 KVSERDTISQISLDSCDSRDQGPPVVFNIGDVRLRHCSNLSCENTKSFSND------PEDPSAAA 1388
            ::|:...:.::..|..:.       |.:.||.:.:........:.:.|..|      |.:|:...
  Rat   887 ELSKEQKLVKLLGDIGEK-------VKSAGDAQRKDVLKKEIGSLEEFFKDIKTCHLPLNPALCV 944

  Fly  1389 LKEPWHEKEKLIRESSPYGHLSN--------------WRLLSAIVKCGDDLRQELMATQLLQMFK 1439
                    :.:.|::..| ..||              .:.:|.|.|.||||||:::..|::|:..
  Rat   945 --------KGIDRDACSY-FTSNALPLKITFINANPMGKNISVIFKAGDDLRQDMLVLQIIQVMD 1000

  Fly  1440 IIWQEEQVDLWVRPYKIVCLSNDSGLIEPILNTVSLHQIKKNSN--KSLKEYFIDEYGSPSG--- 1499
            .:|.:|.:|:.:..|..:......|.||.:.:.|:|.:|..:|.  ..|||..|.::.|...
  Rat  1001 NVWLQEGLDMQMIIYGCLATGKAQGFIEMVPDAVTLAKIHLHSGLIGPLKENTIKKWFSQHNHLK 1065

  Fly  1500 ESFRRAQKNFVQSCAAYCLISYLLQVKDRHNGNILFHSDGHIIHIDFGFILSISPKNLGF--EQS 1562
            |.:.:|.:||..|||.:|:::::|.|.||||.||:....||:.|||||..|..:....|.  :::
  Rat  1066 EDYEKALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRA 1130

  Fly  1563 PFKLTP--EFVEVMGGTSSEHWREFNKLLLVGMMSARKHMDRIINFVEIMRSNAHLPCFKNGCSG 1625
            ||..|.  |:....||.:::|:::|.:|........|||...:::.:|:| .:|.||..:.
  Rat  1131 PFIFTSEMEYFITEGGKNTQHFQDFVELCCRAYNIVRKHSQLLLSLLEMM-LHAGLPELRG---- 1190

  Fly  1626 TVQNLRKRFHMNLTEQEMERKVEQ----LVQDSLKSLSTKL 1662
             :::| |..|.||..|:.:.:...    .::.||:....||
  Rat  1191 -IEDL-KYVHDNLRPQDTDLEATSHFTTKIKQSLECFPVKL 1229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	83/305 (27%)
Pik3c2g	NP_446375.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32
		PI3K_rbd	<310..368	CDD:295323	16/62 (26%)
		C2A_PI3K_class_II	535..697	CDD:175979	33/177 (19%)
		PI3Ka	712..879	CDD:294194	32/172 (19%)
		PKc_like	886..1238	CDD:304357	92/367 (25%)
		PX_domain	1267..1367	CDD:295365
		C2	1389..1501	CDD:301316

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810