DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fwd and Pi4kb

DIOPT Version :9

Sequence 1:NP_001356971.1 Gene:fwd / 45374 FlyBaseID:FBgn0004373 Length:1682 Species:Drosophila melanogaster
Sequence 2:NP_001280644.1 Gene:Pi4kb / 107650 MGIID:1334433 Length:816 Species:Mus musculus


Alignment Length:951 Identity:367/951 - (38%)
Similarity:533/951 - (56%) Gaps:171/951 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   749 QPDHSGTVSLVGSPNGGSSV--------------PQDLVKSPTDISKKKEFFSLLTSSSSIKAAA 799
            :|....|.|..|: ||||.:              |:...|:..::.:|            :|...
Mouse    12 KPTSEPTPSPSGN-NGGSLLSVITEGVGELSVIDPEVAQKACQEVLEK------------VKLLH 63

  Fly   800 AAAANSAASTPPATPTEALAANS-NSKLQPLSDPSADLKVKERTLNLRLPGDSEGSEGALTKCSS 863
            ...|.|:    ..||.|.:..:. :::::.|.||.|.::.:|..:.   .|.:.|:.....:...
Mouse    64 GGVAISS----KGTPLELVNGDGVDNEIRCLDDPPAQIREEEDEMG---AGVASGTAKGARRRRQ 121

  Fly   864 INSIHKLKLPVPGVVKYFISEKAPVSDVLQKPEKGQSGLLRFFESPVFNIHFAVHYLFYSKEPGV 928
            .||..                              ||.|||.|||.:|:|..|:.||:.||||||
Mouse   122 NNSAK------------------------------QSWLLRLFESKLFDISMAISYLYNSKEPGV 156

  Fly   929 LSFIGNKIFSFPDQEVDLYIPQLVVMYIQMDE-LAEVLDPYLTIRCRKSVDFSLKCLWLLEAYNY 992
            .::|||::|.|.:::||.|:|||:.|||.||| :.:.:.||:..|||:|::|||:|..||.||:.
Mouse   157 QAYIGNRLFYFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSS 221

  Fly   993 QVDSLGNSHNSSRK-SKLALMKEIFSKREHKQTQNDLKSAGTGGLHVGEPRSVVALAKKTHHRSQ 1056
            .:......|:...| .||.|..|:  |..|::.:....|..        |.:.::.:|:||.||:
Mouse   222 DMHISTQRHSRGTKLRKLILSDEL--KPAHRKRELPTLSPA--------PDTGLSPSKRTHQRSK 276

  Fly  1057 SDATVLLADFRSPHTLSIS---HRMYQQPPYTTQTLPTTPAKLCLGDLTSGHAFDNGCTCFETVR 1118
            ||||.         ::|:|   .|....|....:....:         :|..:.||         
Mouse   277 SDATA---------SISLSSNLKRTASNPKVENEDEELS---------SSTESIDN--------- 314

  Fly  1119 GQVNGLLGQRTLCSCGAP-KTSPQKEFMKALMNVGKNLTSWPSKAEKTSALRMSLNLINKNLPAR 1182
                         |..:| :.:|::||:|:||.:||.|.:.|:|.:||..|...|:|:|..||||
Mouse   315 -------------SFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPAR 366

  Fly  1183 VWLPLYSDIPHHVVRITEEKTAVLNSKDKTPYIIYVEVVEIPDIYTSPLIPKMMPS--LRHTKSE 1245
            ||||. :...|||||:...:..|||||||.||:|||||:|..:..|:. :|..:|.  :|.|:|.
Mouse   367 VWLPT-AGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTS-VPARIPENRIRSTRSV 429

  Fly  1246 EHLDGSCLNSHQHLSCSRTSSCSSSQQGTSCRRKKGADVDGGCGDAGPHNSCSNVHSLGGLQFQE 1310
            |:|. .|..:|:.                               .||..::..|..:       :
Mouse   430 ENLP-ECGITHEQ-------------------------------RAGSFSTVPNYDN-------D 455

  Fly  1311 DDVWSQEEDEITAQYLNMRKV--SERDTISQISLDSCDSRDQGPPVVFNIGDVRLRHCSNLSCEN 1373
            |:.||  .|:|....:.:.:|  :..|.|||.|:||..|::...||....||:|.|....|:...
Mouse   456 DEAWS--VDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTP 518

  Fly  1374 TKSFSNDPEDPSAAALKEPWHEKEKLIRESSPYGHLSNWRLLSAIVKCGDDLRQELMATQLLQMF 1438
            | :|..|||||||.||||||.||.:.|||.||||||.||||||.||||||||||||:|.|:|:..
Mouse   519 T-AFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQL 582

  Fly  1439 KIIWQEEQVDLWVRPYKIVCLSNDSGLIEPILNTVSLHQIKKNSNKSLKEYFIDEYGSPSGESFR 1503
            :.||::|:|.||::||||:.:|.|||:|||::|.||:||:||.|..||.:||:.|:||.:.|:|.
Mouse   583 QSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFL 647

  Fly  1504 RAQKNFVQSCAAYCLISYLLQVKDRHNGNILFHSDGHIIHIDFGFILSISPKNLGFEQSPFKLTP 1568
            .||:|||||||.|||:.||||||||||||||..::|||||||||||||.||:|||||.|.||||.
Mouse   648 SAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTT 712

  Fly  1569 EFVEVMGGTSSEHWREFNKLLLVGMMSARKHMDRIINFVEIMRSNAHLPCFKNGCSGTVQNLRKR 1633
            |||:||||.:.:.:..:..|:|.|:::||||||:::..||||:..:.||||..  |.|::||::|
Mouse   713 EFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHG--SSTIRNLKER 775

  Fly  1634 FHMNLTEQEMERKVEQLVQDSLKSLSTKLYDGYQYYTNGIL 1674
            |||::||::::..|||:|..|::|::||||||:||.||||:
Mouse   776 FHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM 816

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fwdNP_001356971.1 PI4Kc_III_beta 1385..1674 CDD:270712 176/288 (61%)
Pi4kbNP_001280644.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30 8/18 (44%)
Interaction with ACBD3. /evidence=ECO:0000250|UniProtKB:Q9UBF8 2..68 12/68 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 101..120 3/21 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 250..318 19/115 (17%)
PI4Kc_III_beta 529..816 CDD:270712 176/288 (61%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167850675
Domainoid 1 1.000 178 1.000 Domainoid score I3558
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H6741
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S2505
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003785
OrthoInspector 1 1.000 - - oto93875
orthoMCL 1 0.900 - - OOG6_101543
Panther 1 1.100 - - LDO PTHR10048
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1764
SonicParanoid 1 1.000 - - X2640
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.680

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