DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fwd and pik3c2a

DIOPT Version :9

Sequence 1:	NP_001356971.1	Gene:	fwd / 45374	FlyBaseID:	FBgn0004373	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_001128289.1	Gene:	pik3c2a / 100038240	XenbaseID:	XB-GENE-484563	Length:	1690	Species:	Xenopus tropicalis

Alignment Length:	1599	Identity:	331/1599 - (20%)
Similarity:	570/1599 - (35%)	Gaps:	480/1599 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 PSVHGR--PNLSLAPAGVPGSVNPPKRISTHQRNLSLDFRSMGILLPPVSQVTNNHINH--TQHH 358
            |...||  |:|.:.|.      :..|:.:..:..|.:|          |.::|:..:..  ...|
Frog    63 PPASGRQEPDLMVFPE------SDAKKKNNAETFLGID----------VEKLTDAEMERLLLDDH 111

  Fly   359 RNRSLDSALQRIPEVEVSSPNAESENTFCSPSILGATMCSKIATTAATVTSALSP--PGTPTPAL 421
            .::....|:.:.|   |::|.|       ||...|.....:         |..:|  .||.|..|
Frog   112 FDQRKPLAISQAP---VANPRA-------SPQFYGQPSFQR---------SQWAPGIQGTGTVNL 157

  Fly   422 MSTACTPTIGAVKGNVQHPVPKHEQSISLAAACRSSAVVESCPT------------LRMRPKS-- 472
            :     |:..|......||. ::..:.|:.|..|...|..|.||            ...:|:.
Frog   158 L-----PSFSASYPKCAHPF-QNGYNASVPAIRRHDPVYLSLPTGSQYVSYQMAARAPFQPRGNL 216

  Fly   473 ---SESVAANGQEMIGVIVSST---GNGSSSSNNSCSSAGSTKKREDLTSLGSDDSGIICGSESD 531
               |.:|:.:..::...|.|::   .||.||:....:.:.||..    |..|:||:..|  ::.|
Frog   217 SSYSNTVSPDMAKLFDKIASTSEFVKNGRSSAEADAAKSESTSP----TVQGADDADSI--NKFD 275

  Fly   532 QISLNRICHSHESLDSGEMDADAD------AEEECVDLMDTTSIDEE-YNIMQPDHLCLYPPQAA 589
            .:.|:.:  |...:||.:....|.      ::.:..|..|...::|: .....|:......|..|
Frog   276 WLDLDPL--SKPKVDSTDSSNHAQGIGASPSDSKVKDPWDAVLLEEKPIKYSSPEKKLNGKPSGA 338

  Fly   590 S-TELDCRTLRPSR-KQKRQQQQVLERKNLPSQN----QIESEDSVDAGV---DARTRYR----- 640
            : |......:||:. :||..|.|......:|::|    ::|::|...|..   .|:.|.:
Frog   339 TVTRSLSLNIRPTHLQQKWDQPQKDSGTRVPAENSLLKELEADDEEVAAFCQEVAKLRKKFPSSR 403

  Fly   641 -----------VM---NMSQAAINVELGTASNEIDPDVNYRESHQDPIADAPSLSTP-------- 683
                       ||   |:|....||::   |.||       |..|.|:.....:|:|
Frog   404 LQTNPGFVLSPVMLQRNLSAEIANVKV---SIEI-------EGFQQPVTFTCDVSSPVELIIMQA 458

  Fly   684 ---------------------------------------------------SVASTASATPSVTP 697
                                                               .:....:.:..:..
Frog   459 LCWVHDDLSQVDIESYILKVCGQEEVLQNKHCLGSHEYIQLCRKWDTEIRLQLLCHGTVSRDLAR 523

  Fly   698 TPIATPTPTESTKNDQVLFKNFFGATKNAIFRTAQSIIE----NHEKKNAAKQKEQPDHSGTVSL 758
            |.....:|.:..|:..|:.:.|    |..|  |.|||.|    .||:.:...:.|    |....|
Frog   524 TAEDDASPVDLNKHLAVVDRPF----KEPI--TRQSIEELLDTYHEQVSVCLKHE----SNPYRL 578

  Fly   759 VGSPNGGSSVPQDLVKSPTDISKKKEFFSLLTSSSSIKAAAAAAANSAASTPPATPTEALAANSN 823
            |          :.|:|....|.|..........:.|:|     ....|.:.|.:...||...|.:
Frog   579 V----------EQLIKVVRSICKTVGSVETPAITESVK-----KLRRAVNLPRSRSIEASPTNLS 628

  Fly   824 SKLQPLSDPSADLKVKERTLNLRLPGD---------SEGSEGALTKCSSINSIHKLKLPVPGVVK 879
            ....|.|...:|..::| ||.| |..|         |.|:..|...              ||
Frog   629 DHRSPDSARQSDSPLQE-TLAL-LTTDLHNLLQLHFSSGNSAATAP--------------PG--- 674

  Fly   880 YFISEKAPVSDVLQKPEKGQSGLLRFFESPVFNIH---------FAVHYLFYSKEPGVLSFIGN- 934
                 ..|:.:....|:.     |:|   .:|..|         |..:||       |.|.|.|
Frog   675 -----GRPLKEARTSPDH-----LQF---TIFAAHGIPTGWVSCFEKYYL-------VCSLIHNG 719

  Fly   935 --KIFSFPDQEVDLY--------IPQLVVMYIQMDELAEVLDPYLTIRCRKSVDFSLKCLWLLEA 989
              |......::|..|        ..:|::..||:.:|                  .|:.:..|..
Frog   720 KDKFKPVQSKKVGTYKSFFYLVKWDELIIFPIQISQL------------------PLESILQLTL 766

  Fly   990 YNYQVDSLGNSHNSSRKSKLALM-----KEIFSKREHKQTQNDLKSAGTGGLHVGEP-RSVVALA 1048
            |.....:.|.|.:::::.|...|     ..:|:.|.       :...||..||:... .:..|.|
Frog   767 YGILNPNSGGSPDANKQRKGPEMLGRVSLPLFTFRR-------MLIGGTKLLHLWTSFHTGPAPA 824

  Fly  1049 KKTHHRSQSDATVLLADFRSPHTLSISHRMYQQPPYTTQTLPTTPAKLCLGDLTSGHAFDNGCTC 1113
            ..|...:|....||..||             ..|.:....:|..|.|.|        |:.:..:.
Frog   825 GTTRKTNQMQRIVLQVDF-------------PLPAFDIVYIPPHPTKSC--------AWQSIESL 868

  Fly  1114 FETVRGQVNGLLGQRTLCSCGAPKTSPQKEFMKALMNVGKNLTSWPSKAEKTSALRMSLNLINKN 1178
            .:..:.::..||.:.:  :.|..|  .:|.|:            | .|.......|.||..|..:
Frog   869 DKDAKSRLLSLLAKES--AFGLSK--EEKAFL------------W-EKRYYCLEHRNSLPKILAS 916

  Fly  1179 LPARVWLPLY-SDIPHHVVRITEEKTAV-----LNSK--DKTPYIIYVEVVE--IPDIYTSPLIP 1233
            .|.  |...| ||| :.::......|||     |:|:  |:....:.|:.||  :.|......:|
Frog   917 APN--WDVAYLSDI-YALIHEWPPMTAVSALELLDSRFSDQEVRTVAVKWVEEGLSDDELVDFLP 978

  Fly  1234 KMMPSLRHTKSEEHLDGSCLN------------SHQHLSCSRTSSCSSSQQGTSCRRKKGADVDG 1286
            :.:.:|::   |.:||.|.:.            :| :|......|.:....||...|..|| :..
Frog   979 QFVQALKY---ELYLDNSLVRFLLTRALGNIRITH-YLYWLLKDSLNDPYFGTRYERILGA-LLS 1038

  Fly  1287 GCGDAGPHNSCSNVHSLGGLQFQEDDVWSQEEDE----------ITAQYLNMRKVSERDTISQIS 1341
            .||.              ||         :||.|          :.|:.:.....|.|..:.|..
Frog  1039 VCGK--------------GL---------REELEKQTRLTQLLGVVAEKVRQASGSARQVVLQEG 1080

  Fly  1342 LDSCDSRDQ------------GPPVVFNIGDVRLRHCSNLSCENTKSFSNDPEDPSAAALKEPWH 1394
            ::    |.|            .|.:|..  ::.::.||..|       ||      |..||....
Frog  1081 ME----RVQLLFRKTKCRLPLSPSLVAK--ELNIKACSFFS-------SN------AVPLKVTMV 1126

  Fly  1395 EKEKLIRESSPYGHLSNWRLLSAIVKCGDDLRQELMATQLLQMFKIIWQEEQVDLWVRPYKIVCL 1459
            ..:.|..|            ::::.|.|:||||:::|.|::::...:|.:|.:||.:..:|.:..
Frog  1127 NADPLGEE------------INSMFKVGEDLRQDMLALQMIKIMDKLWLQEGLDLRMVLFKCLST 1179

  Fly  1460 SNDSGLIEPILNTVSLHQIKKN-------SNKSLKEYFIDEYGSPSGESFRRAQKNFVQSCAAYC 1517
            ..|.|::|.:|:..:|.:|:..       .:|.|.|: :.:| :||.|.:.:|.:||:.|||..|
Frog  1180 GRDRGMVELVLSADTLRKIQVEYGVTGSFKDKPLAEW-LRKY-NPSEEDYAKASENFIYSCAGCC 1242

  Fly  1518 LISYLLQVKDRHNGNILFHSDGHIIHIDFGFILSISPKNLGF--EQSPFKLTPEFVEVMGG--TS 1578
            :.:|:|.:.||||.||:..:.||:.|||||..|..:.....|  :::||.||.:...|:.|  ..
Frog  1243 VATYVLGICDRHNDNIMLRTTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKP 1307

  Fly  1579 SEHWREFNKLLLVGMMSARKHMDRIINFVEIMRSNAHLPCFKNGCSGTVQNLRKRFHMNLTEQEM 1643
            :..::.|..|........|||....:|.:.:|     ||......:| :|:| |..|..|..|..
Frog  1308 TRRFQLFVDLCCQAYNLLRKHTSLFLNLLSLM-----LPSGLPELTG-IQDL-KYVHDALQPQAT 1365

  Fly  1644 ERKV----EQLVQDSLKSLSTKLYDGYQYYTNGILXERF 1678
            :.:.    .:|::.||.|::||    :.::.:. | :||
Frog  1366 DTEATIFFTRLIESSLGSVATK----FNFFIHN-LAQRF 1399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	83/303 (27%)
pik3c2a	NP_001128289.1	PI3K_rbd	426..512	CDD:395642	10/95 (11%)
		C2A_PI3K_class_II	679..852	CDD:175979	41/225 (18%)
		PI3Ka	870..1040	CDD:412275	42/194 (22%)
		PI3Kc_C2_alpha	1045..1397	CDD:270720	100/396 (25%)
		PX_PI3K_C2_alpha	1427..1535	CDD:132822
		C2B_PI3K_class_II	1564..1685	CDD:176027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000