DRSC/TRiP Functional Genomics Resources

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Protein Alignment fwd and pik3cb

DIOPT Version :9

Sequence 1:NP_001356971.1 Gene:fwd / 45374 FlyBaseID:FBgn0004373 Length:1682 Species:Drosophila melanogaster
Sequence 2:XP_005157523.1 Gene:pik3cb / 100002263 ZFINID:ZDB-GENE-030131-1904 Length:1080 Species:Danio rerio


Alignment Length:1251 Identity:246/1251 - (19%)
Similarity:437/1251 - (34%) Gaps:383/1251 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   548 GEMDADADAEEECVDLMDTTSIDEEYNIMQPDHLCLYPPQAASTELDCRTLRPSRKQKRQQQQVL 612
            |||:...   .|||   :..::.||.. .:...||...|.....:|..|....:.:....:..||
Zfish    66 GEMEGHM---FECV---NQAAVHEELE-DETRRLCDVRPFLPVLKLITRNCGRAERLLDSKIGVL 123

  Fly   613 ERKNLPSQNQIESEDSVD-------AGVDARTRYRVMNMSQ---AAINVELGTASNEIDPDVNYR 667
            ..|.|...:.::.::..|       ...:...:.::|:..|   ::.:.:|.|:|  :|..:...
Zfish   124 IGKGLHELDALQDQEVKDFRSKMKRISEEKMQQMQMMSWGQWLRSSYSPQLDTSS--LDNLIERH 186

  Fly   668 ES------HQDPIADAPSLSTPSVASTASATPSVTPTPIATPTPTESTKNDQVLFKNFFGATKNA 726
            |.      |.|...|..||.. |:..|.|   .|....:.....|...:.|       .||..|.
Zfish   187 EGIIKITMHYDQSQDTASLKV-SLNCTVS---EVMDHALKKWQTTHGPEED-------IGARSNY 240

  Fly   727 IFRTAQ---------SIIENHEKKNAAKQKEQPDHSGTV--SLVGS------PNGGSSVPQDLVK 774
            :.|.:.         .:|:....:......|.| |...|  .:|.|      ...||.:.:....
Zfish   241 VLRVSDRLEFLFEDYPLIQYKYIRACLSTGENP-HLTVVHFDIVKSMFEKEIATVGSVLARKTSN 304

  Fly   775 SPTDISKKKEFFSLLTSSSSIKAAAAAAANSAASTPPATPTEALAANSNSKLQPL------SDPS 833
            .|..:..||...::.|||.           ||:..|....|.....:|..::..:      ::.:
Zfish   305 PPLPLPPKKRQTTVRTSSM-----------SASQLPQQLHTCVWKVHSLFRINLVKANKVNAEDA 358

  Fly   834 ADLKVKERTLNLRLPGDSEGSE----GALTKCSSINSIH------KLKLPV---PGVVKYFISEK 885
            |.::|:        .|...|:|    .|::..||..|.|      :..:||   |.:.:...:..
Zfish   359 AKIQVR--------AGLFHGTELLCKTAVSNESSSRSEHVWNKTLEFDIPVCDLPRMARLCFAIY 415

  Fly   886 APVSDVLQKPEKGQSGLLRFFESPVFNIHFA--VHYLFYSKEPGVLSFIGNKIFSFPDQ----EV 944
            | |.|.::|....::..|..:::    |..|  |||        .::::...:|.:..|    ::
Zfish   416 A-VMDKVKKQRSTKNTHLNKYQT----IRKAGKVHY--------PIAWVNTMVFDYRGQLKTGDI 467

  Fly   945 DLY----IPQLVVMYIQMDELAEVLDPYLTIRCRKSVDFSLKCLWLLEAYNYQVDSLGNSHNSSR 1005
            .|:    .|         |||.|:|:|..||:.....:.:.:.......|            |::
Zfish   468 ILHCWSSFP---------DELEEMLNPIGTIQTNPYTENATELHISFPEY------------STQ 511

  Fly  1006 KSKLALMKEIFSKREHKQTQNDLKSAGTGGLHVGEPRSVVALAKKTHHRSQSDATVLLADFRSPH 1070
            ........:|..|.......:|..|.|.||             ||.:                  
Zfish   512 PVVFPAFDKILEKAAEIAGASDSMSMGRGG-------------KKFY------------------ 545

  Fly  1071 TLSISHRMYQQPPYTTQTLPTTPAKLCLGDLTSGHAFDNGCTCFETVRGQVNGLLGQRTLCSCGA 1135
             :.:...|.:.|          .::||          :|......|:|..          |....
Zfish   546 -IELKEIMERDP----------LSQLC----------ENEKDLIWTLRYD----------CRENF 579

  Fly  1136 PKTSPQKEFMKALMNVGKNLTSWPSKAEKTSALRMSLNLINKNLPARVWLPLYSDIPHHVVRITE 1200
            |::.|     |.|::|     .| ||.|..:.|:..|.:..|..|......|..:.|...||   
Zfish   580 PQSLP-----KLLLSV-----KW-SKHEDMAQLQALLQIWPKLSPRDALELLDFNYPDQYVR--- 630

  Fly  1201 EKTAVLNSKDKT-----PYII-YVEVVEIPDIYTSP----LIPKMMPSLR-------HTKSEEH- 1247
             :.||...||.:     .|:: .|:|:.....|...    |:.:...|.:       |.:||.: 
Zfish   631 -EFAVSCLKDMSDDELLQYLLQLVQVLRYEPYYDCSLSRFLLERAQTSRKIGHFLFWHLRSEMYM 694

  Fly  1248 ----------LDGSCLNSHQHLSC------------------------SRTSSCSSSQQGTSCRR 1278
                      |:..|.....|:..                        ::|......:...||.|
Zfish   695 PAVSVHFALILEAYCRGCIPHIEVLKKQVEALNKLKAVNELIKLGTIKTKTKQAHLKEAMMSCLR 759

  Fly  1279 KKGADVDGGCGDAGPHNSCSNVHSLGGLQFQEDDVWSQEEDEITAQYLNMRKVSERDTISQISLD 1343
            :.|.           ..:.|::||                           .::....::.:|::
Zfish   760 QTGF-----------IETLSDLHS---------------------------PLNPNILLAGVSVE 786

  Fly  1344 SC---DSRDQGPPVVFNIGDVRLRHCSNLSCENTKSFSNDPEDPSAAALKEPWHEKEKLIRESSP 1405
            .|   ||:.:...:|:|                                       .||:     
Zfish   787 KCKYMDSKMKPLWIVYN---------------------------------------NKLL----- 807

  Fly  1406 YGHLSNWRLLSAIVKCGDDLRQELMATQLLQMFKIIWQEEQVDLWVRPYKIVCLSNDSGLIEPIL 1470
                 ....:..|.|.||||||:::..|:|::..::|:|..:||.:.||..:...:.|||||.:.
Zfish   808 -----GGETVGIIFKNGDDLRQDMLTLQILKLMDLLWKEANLDLRIVPYGCLATGDHSGLIEVVS 867

  Fly  1471 NTVSLHQIKKNS---------NK-SLKEYFIDEYGSPSGESFRRAQKNFVQSCAAYCLISYLLQV 1525
            :..::..|:|.|         || :|..:..|:   .||::..:|.:.|..|||.||:.:|:|.:
Zfish   868 SADTIANIQKTSSNMAAAAAFNKDALLNWLKDK---NSGDALDKAIEEFTLSCAGYCVATYVLGI 929

  Fly  1526 KDRHNGNILFHSDGHIIHIDFGFILSISPKNLGF--EQSPFKLTPEFVEVM--GGT-SSEHWREF 1585
            .|||:.||:..|.|.:.|||||.||.......|.  |:.||.||.:|:.|:  |.| ::|.:..|
Zfish   930 GDRHSDNIMVRSTGQLFHIDFGHILGNFKSKFGIKRERVPFILTHDFIHVIQEGKTGNTEKFGNF 994

  Fly  1586 NKLLLVGMMSARKHMDRIINFVEIMRSNAHLP---CFKNGCSGTVQNLRKRFHMNLTEQEMERKV 1647
            .:......|..||:.:..|....:|.: |.||   ..|:     :|.|:....:..|::|..::.
Zfish   995 RQYCEEAYMILRKNGNLFITLFALMLT-AGLPELTSVKD-----IQYLKDSLALGKTDEEALKQF 1053

  Fly  1648 EQLVQDSLK-SLSTKL 1662
            .|...::|: |.:||:
Zfish  1054 RQKFDEALRESWTTKV 1069

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fwdNP_001356971.1 PI4Kc_III_beta 1385..1674 CDD:270712 85/297 (29%)
pik3cbXP_005157523.1 PI3K_p85B 35..110 CDD:280372 13/50 (26%)
PI3K_rbd 176..281 CDD:295323 24/118 (20%)
C2_PI3K_class_I_beta_delta 334..511 CDD:176075 39/218 (18%)
PI3Ka 548..713 CDD:294194 40/209 (19%)
PKc_like 716..1077 CDD:304357 99/450 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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