DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Treh and treh

DIOPT Version :9

Sequence 1:	NP_726025.1	Gene:	Treh / 45368	FlyBaseID:	FBgn0003748	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	XP_001336187.3	Gene:	treh / 795901	ZFINID:	ZDB-GENE-070912-84	Length:	577	Species:	Danio rerio

Alignment Length:	575	Identity:	254/575 - (44%)
Similarity:	348/575 - (60%)	Gaps:	28/575 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 CLVALSQAKTYSLPDLTTDYNNAIPVDEEEAQDPFASCKIYCEGNLLHTIQTAVPKLFADSKTFV 80
            ||:.:|....:|..|..     ..|.|.:          |||.|.:|..:|.|  |||.|.|.||
Zfish     3 CLIVISSTLLFSSGDAL-----LAPCDSQ----------IYCTGEVLRQVQMA--KLFDDDKYFV 50

  Fly    81 DMKLNNSPDKTLEDFNAMMEA--KNQTPSSEDLKQFVDKYFSAPGTELEKWTPTDWKENPSFLDL 143
            ||.|..:|:..||.|..:...  ....||.| ||:|:..||..||.|.|:||||||...|:||..
Zfish    51 DMTLTTAPEVVLEAFTNLSSVFPDKAVPSLE-LKKFLQTYFKEPGNEFERWTPTDWHSKPNFLSK 114

  Fly   144 ISDPDLKQWGVELNSIWKDLGRKMKDEVSKNPEYYSIIPVPNPVIVPGGRFIEFYYWDSYWIIRG 208
            :||...:.|..||:|:||.||||::|:|..:||.||.|..|:||:||||||.|.|||||||:|.|
Zfish   115 VSDSKYRSWAEELHSLWKSLGRKIRDDVRDHPELYSQIYTPHPVVVPGGRFRELYYWDSYWVING 179

  Fly   209 LLYSQMFDTARGMIENFFSIVNRFGFIPNGGRVYYHGRSQPPLLTGMVKSYVDFTNDDKFAIDAL 273
            ||.|:|.:||||||.||..:|.|:|.:||||||||..|||||.|..||:.:.:.|.|..|....|
Zfish   180 LLLSEMTETARGMILNFVYLVERYGIVPNGGRVYYERRSQPPFLPLMVERFYEATGDKDFLRQVL 244

  Fly   274 DTLEHEFEFFVNNHNVTVK----NHSLCVYRDSSSGPRPESYREDVETGEEFPTDEAKELHYSEL 334
            ..||.|:.|::.|.:|.|.    .|.|..|......||||||.:|||..|...|:..|:| :.:|
Zfish   245 PALEREYSFWMQNRSVDVMTSELTHILNRYNVPVDHPRPESYSDDVELAEGLSTEAQKQL-WMDL 308

  Fly   335 KAGAESGMDFSSRWFISPTGTNDGNRSALSTTSIVPVDLNAYLYWNAKLIAEFHSKAGNTKKVTE 399
            .:|||||.||||||||..||.|:|:.....|:||:|.||||.:..|.:|:|.||...||.:|..:
Zfish   309 TSGAESGWDFSSRWFIDDTGRNNGSLRDTQTSSILPADLNAIMCRNERLLASFHRSLGNEEKALK 373

  Fly   400 YETKAEKLLLGIQEVLWNEEAGVWLDYDMINQKPRDYYTPTNLSPLWVKAFNISESEKISASVMA 464
            ||......:..::.:||:.|.|.|.||:::|:.....:.|:||:|||.:.:  |:||....:|..
Zfish   374 YEKALSARIKAVESLLWDAEKGAWFDYNLVNKTRHLSFYPSNLAPLWAQCY--SKSEMSDQAVQY 436

  Fly   465 YIERNKLDSFPGGVPNTLSYTGEQWDAPNVWAPMQYILVEGLNNLNTPEAKNMSLKWATRWVKTN 529
            ..:...|| :|.|:|.:||.:|:|||.||.|.|:|:|::|||:.|::..|:.::...|.||::||
Zfish   437 LRDSGGLD-YPNGIPTSLSDSGQQWDMPNAWPPLQHIIIEGLSGLHSAHAQELAFSLAQRWIQTN 500

  Fly   530 FAAFSKDRHMYEKYNADEFGVGGGGGEYEVQTGFGWSNGVIIEWLSKHGRDISIG 584
            :.||.|...|:|||:....|..|||||||||.||||:|||.::.|.::|..:|.|
Zfish   501 WRAFIKYEAMFEKYDVSGDGKPGGGGEYEVQLGFGWTNGVALQLLDQYGDRLSSG 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Treh	NP_726025.1	Trehalase	71..577	CDD:279537	237/511 (46%)
treh	XP_001336187.3	TreA	27..554	CDD:224541	245/533 (46%)
treh	XP_001336187.3	Trehalase	41..548	CDD:302639	237/511 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592952
Domainoid	1	1.000	483	1.000	Domainoid score	I390
eggNOG	1	0.900	-	-		E1_COG1626
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5198
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1334
OMA	1	1.010	-	-		QHG63425
OrthoDB	1	1.010	-	-		D167279at33208
OrthoFinder	1	1.000	-	-		FOG0001723
OrthoInspector	1	1.000	-	-		otm26075
orthoMCL	1	0.900	-	-		OOG6_102186
Panther	1	1.100	-	-	LDO	PTHR23403
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3096
SonicParanoid	1	1.000	-	-		X1112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800