DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Treh and Treh

DIOPT Version :9

Sequence 1:	NP_726025.1	Gene:	Treh / 45368	FlyBaseID:	FBgn0003748	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_001129613.1	Gene:	Treh / 60576	RGDID:	61831	Length:	576	Species:	Rattus norvegicus

Alignment Length:	559	Identity:	242/559 - (43%)
Similarity:	343/559 - (61%)	Gaps:	17/559 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 VDEEEAQDPFASCKIYCEGNLLHTIQTAVPKLFADSKTFVDMKLNNSPDKTLEDFNAMMEAKNQT 105
            :..:||..|....:|||.|.|||.:|.|  :|:.|.|.||||.|..|||:.|:.|:.:..|.|.:
  Rat    15 LSSQEALPPPCESQIYCHGELLHQVQMA--QLYQDDKQFVDMSLATSPDEVLQKFSELAVAHNHS 77

  Fly   106 PSSEDLKQFVDKYFSAPGTELEKWTPTDWKENPSFLDLISDPDLKQWGVELNSIWKDLGRKMKDE 170
            ...|:|:.||..||...|.||:.|||.|||::|.||..|||..|:.|..||:.|||.||:|||.|
  Rat    78 IPREELQNFVQSYFQPVGQELQPWTPEDWKDSPQFLQKISDSRLRVWAEELHKIWKKLGKKMKAE 142

  Fly   171 VSKNPEYYSIIPVPNPVIVPGGRFIEFYYWDSYWIIRGLLYSQMFDTARGMIENFFSIVNRFGFI 235
            |..:||..|:|...:|.|||||||:|||||||||::.|||.|:|..|.:||::||..:|..:|.|
  Rat   143 VLSHPERSSLIYSEHPFIVPGGRFVEFYYWDSYWVMEGLLLSEMASTVKGMLQNFLDLVKTYGHI 207

  Fly   236 PNGGRVYYHGRSQPPLLTGMVKSYVDFTNDDKFAIDALDTLEHEFEFFVNNHNVTV----KNHSL 296
            ||||||||..||.|||||.|::.||..|||..|..:.:.||..|.||:..|..|:|    :::.|
  Rat   208 PNGGRVYYLQRSHPPLLTLMMERYVAHTNDVAFLRENIGTLALELEFWTVNRTVSVGSGGQSYIL 272

  Fly   297 CVYRDSSSGPRPESYREDVETGEEFPTDEAKELHYSELKAGAESGMDFSSRWFISPTGTNDGNRS 361
            ..|.....|||||||.:|.|..:..|..: :|..::|||||||||.||||||.:.  |.:....|
  Rat   273 NRYYVPYGGPRPESYSKDEELAKTVPEGD-RETLWAELKAGAESGWDFSSRWLVG--GPDPDLLS 334

  Fly   362 ALSTTSIVPVDLNAYLYWNAKLIAEFHSKAGNTKKVTEYETKAEKLLLGIQEVLWNEEAGVWLDY 426
            ::.|:.:||.||||:|....:|::.|:|:.||..:...|.....:.|..::.:||:|:.|.|.||
  Rat   335 SIRTSKMVPADLNAFLCQAEELMSNFYSRLGNDTEAKRYRNLRAQRLAAMEAILWDEQKGAWFDY 399

  Fly   427 DMINQKPRDYYTPTNLSPLWVKAFNISESEKISASVMAYIERNKLDSFPGGVPNTLSYTGEQWDA 491
            |:...|....:.|:||:|||...|:   ...::...:.|:|.||:.::..|:|.:|..||:|||.
  Rat   400 DLEKGKKNLEFYPSNLTPLWAGCFS---DPSVADRALKYLEDNKILTYQYGIPTSLRNTGQQWDF 461

  Fly   492 PNVWAPMQYILVEGLNNLNTPEAKNMSLKWATRWVKTNFAAFSKDRHMYEKYNADEFGVGGGGGE 556
            ||.|||:|.:::.||....:|..:.::.:.|..|:||||..:|:...|||||:....|..|||||
  Rat   462 PNAWAPLQDLVIRGLAKSASPRTQEVAFQLAQNWIKTNFKVYSQKSAMYEKYDISNGGHPGGGGE 526

  Fly   557 YEVQTGFGWSNGVIIEWLSKHGRDISIGS-----GCGCL 590
            ||||.||||:||:.:..|.::|..::.|:     |..||
  Rat   527 YEVQEGFGWTNGLALMLLDRYGDQLTSGTQLASLGPHCL 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Treh	NP_726025.1	Trehalase	71..577	CDD:279537	225/509 (44%)
Treh	NP_001129613.1	TreA	16..551	CDD:224541	237/538 (44%)
Treh	NP_001129613.1	Trehalase	43..547	CDD:279537	224/507 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351162
Domainoid	1	1.000	458	1.000	Domainoid score	I466
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5198
Inparanoid	1	1.050	482	1.000	Inparanoid score	I1402
OMA	1	1.010	-	-		QHG63425
OrthoDB	1	1.010	-	-		D167279at33208
OrthoFinder	1	1.000	-	-		FOG0001723
OrthoInspector	1	1.000	-	-		otm46225
orthoMCL	1	0.900	-	-		OOG6_102186
Panther	1	1.100	-	-	LDO	PTHR23403
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910