DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shu and AIP

DIOPT Version :9

Sequence 1:	NP_611837.1	Gene:	shu / 45360	FlyBaseID:	FBgn0003401	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_003968.3	Gene:	AIP / 9049	HGNCID:	358	Length:	330	Species:	Homo sapiens

Alignment Length:	337	Identity:	68/337 - (20%)
Similarity:	126/337 - (37%)	Gaps:	69/337 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 DENIYKRITRTGHVDREAVPNKARVSVRY-SGYWEGETAPFDSSLLRGSKFVFETGQGTVVEGLE 145
            ::.|.||:.:.|..:.....:..:.:..| :.:.:.|....|.|..||.......|:...:...|
Human    10 EDGIQKRVIQEGRGELPDFQDGTKATFHYRTLHSDDEGTVLDDSRARGKPMELIIGKKFKLPVWE 74

  Fly   146 VAVRSMRPYEQAEF------IISYKLLFGEL-----GCPPRIKPKADALFKVEVIDYSLIGDAKG 199
            ..|.:||..|.|:|      ::.|.|:...|     |..| ::.:.......::.::|.:|.| .
Human    75 TIVCTMREGEIAQFLCDIKHVVLYPLVAKSLRNIAVGKDP-LEGQRHCCGVAQMREHSSLGHA-D 137

  Fly   200 IDAIPQE---------------------------DRDKFCVVYPKAVDL-HLHGKDSVKLGRYQS 236
            :||:.|.                           |.:|     .|||.| |..|....:.|..:.
Human   138 LDALQQNPQPLIFHMEMLKVESPGTYQQDPWAMTDEEK-----AKAVPLIHQEGNRLYREGHVKE 197

  Fly   237 AATAFERAVSSLNYCRMAND-------EEERKQTELLTTLNQNLMIVYNKMNKPKRACIMMKALR 294
            ||..:..|::.|...:|...       :.:::.|.||....|..::|..          ..:.|.
Human   198 AAAKYYDAIACLKNLQMKEQPGSPEWIQLDQQITPLLLNYCQCKLVVEE----------YYEVLD 252

  Fly   295 H----LTMGNPSCKALFQEGRALAALGEYNLARNAYLQAQAKQPA-NKEISDEIISMNKRISKYE 354
            |    |...:.:.||.|:.|:|.||:.....|:..:.:.....|| ...:|.|:.::..||.:.:
Human   253 HCSSILNKYDDNVKAYFKRGKAHAAVWNAQEAQADFAKVLELDPALAPVVSRELRALEARIRQKD 317

  Fly   355 EASRDIWARAFS 366
            |..:..:...||
Human   318 EEDKARFRGIFS 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shu	NP_611837.1	FKBP_C	96..189	CDD:278674	19/104 (18%)
		TPR repeat	218..257	CDD:276809	11/46 (24%)
		TPR repeat	262..295	CDD:276809	6/32 (19%)
		TPR repeat	304..329	CDD:276809	8/24 (33%)
AIP	NP_003968.3	FKBP_C	29..>90	CDD:327575	14/60 (23%)
		TPR 1. /evidence=ECO:0000255, ECO:0000269\|PubMed:23300914	179..212		9/32 (28%)
		TPR repeat	183..225	CDD:276809	8/41 (20%)
		TPR repeat	230..260	CDD:276809	8/39 (21%)
		TPR 2. /evidence=ECO:0000269\|PubMed:23300914	231..264		8/42 (19%)
		TPR 3. /evidence=ECO:0000255, ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:23300914	265..298		9/32 (28%)
		TPR repeat	265..293	CDD:276809	8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910