DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shu and FKBP6

DIOPT Version :9

Sequence 1:	NP_611837.1	Gene:	shu / 45360	FlyBaseID:	FBgn0003401	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_003593.3	Gene:	FKBP6 / 8468	HGNCID:	3722	Length:	327	Species:	Homo sapiens

Alignment Length:	315	Identity:	93/315 - (29%)
Similarity:	151/315 - (47%)	Gaps:	18/315 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 DVDGEELRSPWTYSFDELRALMSEI--DENIYKRITRTGHVDREAVPNKARVSVRYSGYWEGETA 119
            |..|:.|       ::.|...|.:|  |..:.|.:.|.|..|  .|...|.|.|:||||.|....
Human    15 DAPGQSL-------YERLSQRMLDISGDRGVLKDVIREGAGD--LVAPDASVLVKYSGYLEHMDR 70

  Fly   120 PFDSSLLRGSKFVFETGQGTVVEGLEVAVRSMRPYEQAEFIISYKLLFGELGCPPRIKPKADALF 184
            ||||:..|.:..:.:.|:...:.|:|:.:.|||..|.|.|:......:|.|||||.|.|....||
Human    71 PFDSNYFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPNYAYGTLGCPPLIPPNTTVLF 135

  Fly   185 KVEVIDYSLIGDAKGIDAIPQEDRDKFCV--VYPKAVDLHLHGKDSVKLGRYQSAATAFERAVSS 247
            ::|::|:....::....|:..|.:|:|.:  |...|......|....:..|:..|...::||:..
Human   136 EIELLDFLDCAESDKFCALSAEQQDQFPLQKVLKVAATEREFGNYLFRQNRFYDAKVRYKRALLL 200

  Fly   248 LNYCRMANDEEERKQTELLTTLNQNLMIVYNKMNKPKRA-CIMMKALRHLTMGNPSCKALFQEGR 311
            |.. |.|..||:.........:..||...|.|:::|..| |...:|   |.:...:.||||:.|:
Human   201 LRR-RSAPPEEQHLVEAAKLPVLLNLSFTYLKLDRPTIALCYGEQA---LIIDQKNAKALFRCGQ 261

  Fly   312 ALAALGEYNLARNAYLQAQAKQPANKEISDEIISMNKRISKYEEASRDIWARAFS 366
            |...|.||..||:..::||.:||.|.:|::|:..:......|.:..:::|.|.|:
Human   262 ACLLLTEYQKARDFLVRAQKEQPFNHDINNELKKLASCYRDYVDKEKEMWHRMFA 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shu	NP_611837.1	FKBP_C	96..189	CDD:278674	35/92 (38%)
		TPR repeat	218..257	CDD:276809	9/38 (24%)
		TPR repeat	262..295	CDD:276809	8/33 (24%)
		TPR repeat	304..329	CDD:276809	11/24 (46%)
FKBP6	NP_003593.3	FKBP_C	51..140	CDD:306713	34/88 (39%)
		TPR	<164..315	CDD:223533	42/154 (27%)
		TPR 1	171..204		7/33 (21%)
		TPR 2	219..252		9/35 (26%)
		TPR repeat	221..247	CDD:276809	8/28 (29%)
		TPR repeat	252..282	CDD:276809	13/29 (45%)
		TPR 3	253..286		15/32 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143559
Domainoid	1	1.000	67	1.000	Domainoid score	I9890
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2672
Inparanoid	1	1.050	124	1.000	Inparanoid score	I4730
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54528
OrthoDB	1	1.010	-	-		D1465346at2759
OrthoFinder	1	1.000	-	-		FOG0004027
OrthoInspector	1	1.000	-	-		oto90271
orthoMCL	1	0.900	-	-		OOG6_107945
Panther	1	1.100	-	-	LDO	PTHR46674
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8869
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840