DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shu and Fkbpl

DIOPT Version :9

Sequence 1:	NP_611837.1	Gene:	shu / 45360	FlyBaseID:	FBgn0003401	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_063926.1	Gene:	Fkbpl / 56299	MGIID:	1932127	Length:	347	Species:	Mus musculus

Alignment Length:	380	Identity:	89/380 - (23%)
Similarity:	139/380 - (36%)	Gaps:	114/380 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EEN----------FEPYTPQLLKNPLSYSDLVKKGVEFEVDN----SQQNHARDLGLDSDSDSDY 52
            |||          |...:|.||...|      |.||..:..|    :|:......|.:.|||.
Mouse    21 EENAQQILNTAIPFRQRSPGLLPEAL------KVGVRPDPANQIVETQEIEHPVAGFEGDSDQ-- 77

  Fly    53 EDALDVDGEELRSPWTYSFDELRALMSEI----DENIYKRITRTGH-VDREAVPNKARVSVRYSG 112
               ..|...|:.       :.|:|  |::    |.:..|:|...|| :|:..:.:|.:|..  .|
Mouse    78 ---FQVSTNEMA-------EHLQA--SDLWYCPDGSFVKKIIVPGHGLDKPKLGSKCQVLA--LG 128

  Fly   113 YWEGETAPFDSSLLRG-SKFVFETGQ------GTVVEGLEVAVRSMRPYEQAEFIISYKLLFGEL 170
            :      ||.|.:..| ::.....||      |   |.:|..:.|||..|:|:..:
Mouse   129 F------PFGSGMPEGWTELTIGIGQWREKMWG---ELMEKCLESMRQGEEAKIHL--------- 175

  Fly   171 GCPPRIKPKADA-LFKVEVIDYSLIGDAKGIDAIPQEDRDKFCVVYPKAVDLHLHGKDSVKLGRY 234
                   |.:.| |.|:.:..::     .|.|:...|..:|..:    |.:.|..|.:..:.|..
Mouse   176 -------PGSSAPLAKLRLDSFT-----NGRDSWEMEAMEKEAL----AKEEHRRGTELFRAGNP 224

  Fly   235 QSAATAFERAVSSLNYCRMANDEEERKQTELLTTLNQNLMIVYNKMNKPKRACIMMKALRHLTMG 299
            |.||..:.||:..|.........|.       |||..||           .||.::  |.|..:.
Mouse   225 QGAARCYGRALRLLLTLPPPGPPER-------TTLYANL-----------AACQLL--LGHPQLA 269

  Fly   300 NPSC-----------KALFQEGRALAALGEYNLARNAYLQAQAKQPANKEISDEI 343
            ..||           |||::.|.|.||||:...|...:.:..|..|.|:...:|:
Mouse   270 AQSCDRVLEREPGHLKALYRRGVARAALGDLEKATADFKKVLAVDPKNRAAKEEL 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shu	NP_611837.1	FKBP_C	96..189	CDD:278674	22/100 (22%)
		TPR repeat	218..257	CDD:276809	10/38 (26%)
		TPR repeat	262..295	CDD:276809	8/32 (25%)
		TPR repeat	304..329	CDD:276809	10/24 (42%)
Fkbpl	NP_063926.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		2/2 (100%)
		TPR_11	208..281	CDD:290150	22/92 (24%)
		TPR 1	208..241		10/32 (31%)
		TPR repeat	208..236	CDD:276809	9/27 (33%)
		TPR repeat	249..279	CDD:276809	11/49 (22%)
		TPR 2	250..283		11/45 (24%)
		TPR_11	252..315	CDD:290150	20/75 (27%)
		TPR 3	284..317		12/32 (38%)
		TPR repeat	284..312	CDD:276809	10/27 (37%)
		TPR_1	285..317	CDD:278916	12/31 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910