DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shu and FKBP14

DIOPT Version :9

Sequence 1:	NP_611837.1	Gene:	shu / 45360	FlyBaseID:	FBgn0003401	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_060416.1	Gene:	FKBP14 / 55033	HGNCID:	18625	Length:	211	Species:	Homo sapiens

Alignment Length:	85	Identity:	21/85 - (24%)
Similarity:	42/85 - (49%)	Gaps:	3/85 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 VRYSGYWEGETAPFDSSLL--RGSKFVFETGQGTVVEGLEVAVRSMRPYEQAEFIISYKLLFGEL 170
            |.|.||.|.:.:.|.|:..  .|....|..|....::|.:..::.|...|:.:.||...|.:|:.
Human    50 VHYEGYLEKDGSLFHSTHKHNNGQPIWFTLGILEALKGWDQGLKGMCVGEKRKLIIPPALGYGKE 114

  Fly   171 GCPPRIKPKADALFKVEVID 190
            | ..:|.|::..:|.:::::
Human   115 G-KGKIPPESTLIFNIDLLE 133

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shu	NP_611837.1	FKBP_C	96..189	CDD:278674	21/82 (26%)
		TPR repeat	218..257	CDD:276809
		TPR repeat	262..295	CDD:276809
		TPR repeat	304..329	CDD:276809
FKBP14	NP_060416.1	FkpA	<43..135	CDD:223619	21/85 (25%)
		EF-hand_7	141..204	CDD:404394
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	208..211
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900