DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shu and fkbp6

DIOPT Version :9

Sequence 1:	NP_611837.1	Gene:	shu / 45360	FlyBaseID:	FBgn0003401	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001122145.1	Gene:	fkbp6 / 402839	ZFINID:	ZDB-GENE-050302-4	Length:	343	Species:	Danio rerio

Alignment Length:	338	Identity:	89/338 - (26%)
Similarity:	155/338 - (45%)	Gaps:	57/338 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 FDELRALMSEI--DENIYKRITRTGHVDREAVPNKARVSVRYSGYWEGETAPFDSSLLRGSKFVF 133
            |..|...|.:|  |..:.|.:...|  :...|...|.||:.:||:.|...|||:::.......:.
Zfish    28 FQRLAPQMQDILGDGGVLKEVIHEG--EGPPVSMHASVSINFSGFIEYTDAPFETTNHLKYPRMM 90

  Fly   134 ETGQGTVVEGLEVAVRSMRPYEQAEFIISYKLLFGELGCPPRIKPKADALFKVEVIDYSLIGDAK 198
            :.|:...:.|||:.:.:|:..|.:.|:...|..:|:|||||.|.|.|..|::|:|:|:
Zfish    91 KLGKDVTLYGLELGLLTMKKGEFSRFLFKPKYAYGDLGCPPHIPPCATVLYEVQVLDF------- 148

  Fly   199 GIDAIPQEDRDKFCVVYPKAVDLHLHGKDSVKLG--------------------RYQSAATAFER 243
             :|:...:|          .:||.|..:::..|.                    ||:.|...:::
Zfish   149 -LDSAQVDD----------FMDLTLEEQNTAPLSVLLNVLDTQRSFGNLCFNKKRYEDARERYKQ 202

  Fly   244 AVSSLNYCRMANDEEERKQTE------LLTTLNQNLMIVYNKMNKPKRACIMMKALRHLTMGNPS 302
            |::.|.. |...|.||:|..|      ||     ||...|.|:.||::|  ::...:.|.:...:
Zfish   203 AMTLLQN-REPEDAEEKKHLEEIKLPFLL-----NLSFTYLKLEKPQKA--LLYGQKALDINPQN 259

  Fly   303 CKALFQEGRALAALGEYNLARNAYLQAQAKQPANKEISDEIISMNKRISKYEEASRDIWARAFS- 366
            .||||:.|:|...:.:|..|::....||||:|.:.:|:..:|.:......|.:..:||..:.||
Zfish   260 TKALFRCGQACLEMKDYEKAQDYLTLAQAKKPFDPDINTLLIKLAHCYKAYLDKEKDICTKMFSG 324

  Fly   367 LKNSKSDVRKTPA 379
            .|.::...||..|
Zfish   325 FKQTEKCQRKNLA 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shu	NP_611837.1	FKBP_C	96..189	CDD:278674	29/92 (32%)
		TPR repeat	218..257	CDD:276809	10/58 (17%)
		TPR repeat	262..295	CDD:276809	10/38 (26%)
		TPR repeat	304..329	CDD:276809	8/24 (33%)
fkbp6	NP_001122145.1	FKBP_C	63..146	CDD:278674	27/82 (33%)
		TPR_12	174..258	CDD:290160	21/91 (23%)
		TPR repeat	214..255	CDD:276809	15/47 (32%)
		TPR_11	228..291	CDD:290150	22/69 (32%)
		TPR repeat	260..286	CDD:276809	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576434
Domainoid	1	1.000	59	1.000	Domainoid score	I10689
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2672
Inparanoid	1	1.050	106	1.000	Inparanoid score	I4909
OMA	1	1.010	-	-		QHG54528
OrthoDB	1	1.010	-	-		D1465346at2759
OrthoFinder	1	1.000	-	-		FOG0004027
OrthoInspector	1	1.000	-	-		otm25144
orthoMCL	1	0.900	-	-		OOG6_107945
Panther	1	1.100	-	-	LDO	PTHR46674
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.810