DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shu and fkbp8

DIOPT Version :9

Sequence 1:	NP_611837.1	Gene:	shu / 45360	FlyBaseID:	FBgn0003401	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_957178.1	Gene:	fkbp8 / 393858	ZFINID:	ZDB-GENE-040426-1849	Length:	406	Species:	Danio rerio

Alignment Length:	393	Identity:	90/393 - (22%)
Similarity:	159/393 - (40%)	Gaps:	70/393 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LVKKGVEFEVDNSQQNHARDLGLDSDSDSD---YEDALDVDGEELRSPWTYSFDELRALMSEIDE 83
            |.||.....:.:|:::......|:.|.|.|   .|||  ..|::..||......|.::..|...|
Zfish    19 LAKKSAGASLLDSREDFEMLEHLEDDVDDDLPPLEDA--GGGKKKSSPAKDPAKEDKSAESPSAE 81

  Fly    84 -----------NIYKRITRTGHVDREAVPNKARVSVRYSGYWEGETAPFDSSLLRGS------KF 131
                       .:.|::...| ...::.|.|.          :..|....::|..|:      ..
Zfish    82 PEEWLDVLGNGQLRKKVLEAG-AGPDSRPQKG----------QNVTIHLKTALTNGTVVDELKDL 135

  Fly   132 VFETGQGTVVEGLEVAVRSMRPYEQAEFIISYKLLFGELG-CPPRIKPKADALFKVEVIDYSLIG 195
            .|..|.|.|::.|::.|:.|...|:|....:.|..:|.|| ..|.:.|.||.|.:|:::.   ..
Zfish   136 SFTLGDGDVLQALDLTVQLMEMGEKALIEAAAKYAYGALGSSAPAVPPDADLLLEVQLLS---AD 197

  Fly   196 DAKGIDAIPQEDRDKFCVVYPKAVDLHLHGKDSVKLGRYQSAATAFERAVSSLNYCRMAND---- 256
            :|..::.:|..:|  ..:...|....::|         ||.|..||  ||:|........:
Zfish   198 EALDLELMPPSER--IILANRKRERGNVH---------YQRADYAF--AVNSYGIALQITEASSR 249

  Fly   257 -----EEERKQTELLTTLNQNLMIVYNKMNKPK---RACIMMKALRHLTMGNP-SCKALFQEGRA 312
                 |||.:..::......|:.....|::..:   |:|:  ..|.|    .| :.||||::|:.
Zfish   250 VDISQEEEEELLDMKVKCLNNMAAAQLKLDHYEAALRSCV--SVLAH----QPDNVKALFRKGKV 308

  Fly   313 LAALGEYNLARNAYLQAQAKQPANKEISDEIISMNKRISKYEEASRDIWARAFSLKNSKSDVRKT 377
            ||..||:..|......|...:|:||.|..|:..:.|:.|:.:.|.:.::.:... ..|.|.|:|.
Zfish   309 LALQGEFAEAIKTLKMALKLEPSNKTIHAELSKLVKKHSEQKGAEQAMYKKMLG-NPSNSSVQKH 372

  Fly   378 PAQ 380
            .|:
Zfish   373 RAK 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shu	NP_611837.1	FKBP_C	96..189	CDD:278674	24/99 (24%)
		TPR repeat	218..257	CDD:276809	9/47 (19%)
		TPR repeat	262..295	CDD:276809	5/35 (14%)
		TPR repeat	304..329	CDD:276809	10/24 (42%)
fkbp8	NP_957178.1	FKBP_C	106..194	CDD:278674	24/97 (25%)
		TPR_11	214..296	CDD:290150	19/98 (19%)
		TPR repeat	214..259	CDD:276809	13/55 (24%)
		TPR repeat	265..293	CDD:276809	4/29 (14%)
		TPR_11	266..330	CDD:290150	18/69 (26%)
		TPR repeat	298..328	CDD:276809	11/29 (38%)
		TPR_1	299..332	CDD:278916	12/32 (38%)
		TPR repeat	333..361	CDD:276809	6/27 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810