DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shu and Fkbp5

DIOPT Version :9

Sequence 1:	NP_611837.1	Gene:	shu / 45360	FlyBaseID:	FBgn0003401	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	XP_006256284.1	Gene:	Fkbp5 / 361810	RGDID:	1309155	Length:	473	Species:	Rattus norvegicus

Alignment Length:	473	Identity:	90/473 - (19%)
Similarity:	162/473 - (34%)	Gaps:	125/473 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 EFEVDNSQQNHARDLGLDSDSDSDYEDALDVDGEELRSPWTYSFDELRALMSEIDENIYKRITRT 92
            |.||...|:....|.|..::.::.....:: .||:              :.::.|..:.|.:.|.
  Rat     8 EAEVFYLQRTMTTDEGTSNNEENPAATVVE-QGED--------------ITTKKDRGVLKIVKRV 57

  Fly    93 GHVDREAVPNKARVSVRYSGYWEGETAPFDSSLLRGSKFVFETGQGTVVEGLEVAVRSMRPYEQA 157
            | ...|......:|.|.|.|.. .....||||..|...|||..|:|.|::..::.|.:|:..|..
  Rat    58 G-TSEETPMIGDKVYVHYKGKL-SNGKKFDSSRDRNEPFVFSLGKGQVIKAWDIGVSTMKKGEIC 120

  Fly   158 EFIISYKLLFGELGCPPRIKPKADALFKVEVIDYS------------------------------ 192
            ..:...:..:|..|..|:|...|...|::|::|:.
  Rat   121 HLLCKPEYAYGSAGSLPKIPSNATLFFEIELLDFKGEDLFEDSGIIRRIKRKGEGYSNPNEGATV 185

  Fly   193 --------------------LIGDAK------GID-AIPQEDRDKFCVVY------------PK- 217
                                :||:.:      ||| |:.:..|::.|::|            ||
  Rat   186 EVHLEGCCAGRVFDCRDVVFVIGEGEDHDIPIGIDKALEKMQREEQCILYLGPQYGFGEAGKPKF 250

  Fly   218 ----------------------------------AVDLHLHGKDSVKLGRYQSAATAFERAVSSL 248
                                              |..:...|....|.|:|..|...:.:.||.|
  Rat   251 GIEPNAELMYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWL 315

  Fly   249 NYCRMANDEEERKQTELLTTLNQNLMIVYNKMNKPKRACIMMKALRHLTMGNPSCKALFQEGRAL 313
            ......:::|.:.....|.....||.:.|.|:.:..:|.........|...|.  |.|::.|.|.
  Rat   316 EMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANE--KGLYRRGEAQ 378

  Fly   314 AALGEYNLARNAYLQAQAKQPANKEISDEIISMNKRISKYEEASRDIWARAFSLKNSKSDVRKTP 378
            ..:.|:..|:..:.:.....|.||....:|....::..::.|..|.::|..|. |.::.|.::..
  Rat   379 LLMNEFESAKGDFEKVLEVNPQNKAARLQISVCQRKAKEHNERDRRVYANMFK-KFAEQDAKEEA 442

  Fly   379 AQ-LEKEAKEQDFNDKME 395
            :: |.|:|.|.....|.|
  Rat   443 SKALSKKAVEGAAGKKHE 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shu	NP_611837.1	FKBP_C	96..189	CDD:278674	26/92 (28%)
		TPR repeat	218..257	CDD:276809	9/38 (24%)
		TPR repeat	262..295	CDD:276809	6/32 (19%)
		TPR repeat	304..329	CDD:276809	6/24 (25%)
Fkbp5	XP_006256284.1	FKBP_C	61..152	CDD:278674	26/91 (29%)
		TPR_11	284..364	CDD:290150	16/79 (20%)
		TPR repeat	285..313	CDD:276809	6/27 (22%)
		TPR_11	336..399	CDD:290150	13/64 (20%)
		TPR	336..367	CDD:197478	6/30 (20%)
		TPR repeat	336..362	CDD:276809	5/25 (20%)
		TPR repeat	367..397	CDD:276809	7/31 (23%)
		TPR_1	369..401	CDD:278916	7/31 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810