DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shu and Fkbp6

DIOPT Version :9

Sequence 1:	NP_611837.1	Gene:	shu / 45360	FlyBaseID:	FBgn0003401	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001099392.1	Gene:	Fkbp6 / 288597	RGDID:	1308926	Length:	327	Species:	Rattus norvegicus

Alignment Length:	335	Identity:	103/335 - (30%)
Similarity:	162/335 - (48%)	Gaps:	47/335 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 EELRSPWTYSFDELRALMSEI--DENIYKRITRTGHVDREAVPNKARVSVRYSGYWEGETAPFDS 123
            ::.:||    ::.|...|.:|  |..:.|.|.|.|..|  .|...|.|.|:||||.|....||||
  Rat    16 DDCQSP----YERLSQRMLDISGDRGVLKDIIREGAGD--PVTPDASVLVKYSGYLEHMDKPFDS 74

  Fly   124 SLLRGSKFVFETGQGTVVEGLEVAVRSMRPYEQAEFIISYKLLFGELGCPPRIKPKADALFKVEV 188
            :..|.:..:.:.|:...:.|:|:.:.|||..|.|.|:......:|.|||||.|.|.|..||::|:
  Rat    75 NCFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPTYAYGTLGCPPLIPPNATVLFEIEL 139

  Fly   189 IDYSLIGDAKGIDAIPQEDRDKFCVV-------YPKAVDLHL------HGKDSVKLGRYQSAATA 240
            ||:           :...:.||||.:       :|....|.:      .|....:..|:..|...
  Rat   140 IDF-----------LDSAESDKFCALSAEQQEQFPLQKVLKVAATEREFGNYLFRQNRFCDAKVR 193

  Fly   241 FERAVSSLNYCRMANDEEER--KQTELLTTLNQNLMIVYNKMNKPKRACIMMKALRH----LTMG 299
            ::||:..| :.|:|..||:.  :..|||..|  ||..||.|:::|      ..|||:    |.:.
  Rat   194 YKRALLLL-HRRLAICEEQHLVEPAELLVLL--NLSFVYLKLDRP------AMALRYGEQALLID 249

  Fly   300 NPSCKALFQEGRALAALGEYNLARNAYLQAQAKQPANKEISDEIISMNKRISKYEEASRDIWARA 364
            ..:.||||:.|:|...|.||..||:..::||.:||.|.:|::|:..::.....|.:..|::..|.
  Rat   250 KRNAKALFRCGQACLLLTEYEQARDFLVRAQKEQPCNHDINNELKKLSSHYRDYVDREREMCHRM 314

  Fly   365 FSLKNSKSDV 374
            |:...|.|.|
  Rat   315 FAPCGSGSSV 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shu	NP_611837.1	FKBP_C	96..189	CDD:278674	36/92 (39%)
		TPR repeat	218..257	CDD:276809	9/44 (20%)
		TPR repeat	262..295	CDD:276809	12/32 (38%)
		TPR repeat	304..329	CDD:276809	11/24 (46%)
Fkbp6	NP_001099392.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		0/3 (0%)
		FKBP_C	51..140	CDD:395196	35/88 (40%)
		TPR	<164..284	CDD:223533	38/128 (30%)
		TPR 1	171..204		6/33 (18%)
		TPR repeat	218..248	CDD:276809	14/37 (38%)
		TPR 2	219..252		13/40 (33%)
		TPR 3	253..286		15/32 (47%)
		TPR repeat	253..281	CDD:276809	12/27 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337304
Domainoid	1	1.000	69	1.000	Domainoid score	I9465
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2672
Inparanoid	1	1.050	128	1.000	Inparanoid score	I4581
OMA	1	1.010	-	-		QHG54528
OrthoDB	1	1.010	-	-		D1465346at2759
OrthoFinder	1	1.000	-	-		FOG0004027
OrthoInspector	1	1.000	-	-		oto97391
orthoMCL	1	0.900	-	-		OOG6_107945
Panther	1	1.100	-	-	LDO	PTHR46674
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810