DRSC/TRiP Functional Genomics Resources

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Protein Alignment shu and FKBP8

DIOPT Version :9

Sequence 1:NP_611837.1 Gene:shu / 45360 FlyBaseID:FBgn0003401 Length:455 Species:Drosophila melanogaster
Sequence 2:NP_036313.3 Gene:FKBP8 / 23770 HGNCID:3724 Length:413 Species:Homo sapiens


Alignment Length:376 Identity:81/376 - (21%)
Similarity:137/376 - (36%) Gaps:57/376 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 ENFEPYTPQLLKNPLSYSDLVKKGVEFEVDNSQQNHARDLGLDSDSDSDYEDALDVDGEELRSPW 67
            |..||..|.....|......|..|||......::....:...|.......||......||...|.
Human     6 EPSEPSAPLPAGVPPLEDFEVLDGVEDAEGEEEEEEEEEEEDDLSELPPLEDMGQPPAEEAEQPG 70

  Fly    68 TYSFDELRALMSE-------------IDENIYKRITRTGHVDREAVPNKARVSVRYSGYWEGETA 119
            ..:.:.|.|:..|             :...:.::.|........:.|.|.:|          .|.
Human    71 ALAREFLAAMEPEPAPAPAPEEWLDILGNGLLRKKTLVPGPPGSSRPVKGQV----------VTV 125

  Fly   120 PFDSSLLRGSK------FVFETGQGTVVEGLEVAVRSMRPYEQAEFIISYKLLFGELGC-PPRIK 177
            ...:||..|::      .||..|...|::.|:::|..|...|.|......|..:|..|. .|.|.
Human   126 HLQTSLENGTRVQEEPELVFTLGDCDVIQALDLSVPLMDVGETAMVTADSKYCYGPQGSRSPYIP 190

  Fly   178 PKADALFKVEV---IDYSLIGDAKGIDAIPQEDRDKFCVVYPKAVDLHLHGKDSVKLGRYQSAAT 239
            |.|....:|.:   :|...:....|.:.:...:|.:.|            |....:...:..||.
Human   191 PHAALCLEVTLKTAVDGPDLEMLTGQERVALANRKREC------------GNAHYQRADFVLAAN 243

  Fly   240 AFERAVSSLNYCRMAN--DEEERKQTELLTTLNQNLMIVYNKMNKPK---RACIMMKALRHLTMG 299
            :::.|:.::......:  .|||.:..:|......||.....|::..:   |:|.::  |.|    
Human   244 SYDLAIKAITSSAKVDMTFEEEAQLLQLKVKCLNNLAASQLKLDHYRAALRSCSLV--LEH---- 302

  Fly   300 NP-SCKALFQEGRALAALGEYNLARNAYLQAQAKQPANKEISDEIISMNKR 349
            .| :.||||::|:.||..|||:.|......|...:|:||.|..|:..:.|:
Human   303 QPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKK 353

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shuNP_611837.1 FKBP_C 96..189 CDD:278674 24/102 (24%)
TPR repeat 218..257 CDD:276809 4/40 (10%)
TPR repeat 262..295 CDD:276809 7/35 (20%)
TPR repeat 304..329 CDD:276809 11/24 (46%)
FKBP8NP_036313.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..68 14/61 (23%)
FKBP_C 113..202 CDD:278674 24/98 (24%)
TPR_11 222..304 CDD:290150 17/99 (17%)
TPR 1 222..255 6/44 (14%)
TPR repeat 231..267 CDD:276809 6/35 (17%)
TPR repeat 272..302 CDD:276809 6/31 (19%)
TPR 2 273..306 8/38 (21%)
TPR_11 274..338 CDD:290150 20/69 (29%)
TPR 3 307..340 13/32 (41%)
TPR 307..340 CDD:197478 13/32 (41%)
TPR repeat 307..335 CDD:276809 12/27 (44%)
TPR repeat 341..369 CDD:276809 4/13 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0545
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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