DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment shu and FKBP5

DIOPT Version :9

Sequence 1:NP_611837.1 Gene:shu / 45360 FlyBaseID:FBgn0003401 Length:455 Species:Drosophila melanogaster
Sequence 2:NP_001139247.1 Gene:FKBP5 / 2289 HGNCID:3721 Length:457 Species:Homo sapiens


Alignment Length:445 Identity:86/445 - (19%)
Similarity:155/445 - (34%) Gaps:116/445 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 DGEELRSPWTYSFDELRALMSEIDENIYKRITRTGHVDREAVPNKARVSVRYSGYWEGETAPFDS 123
            :.||  ||.....::...:.|:.|..:.|.:.|.|:.:...:... :|.|.|.|.. .....|||
Human     9 NNEE--SPTATVAEQGEDITSKKDRGVLKIVKRVGNGEETPMIGD-KVYVHYKGKL-SNGKKFDS 69

  Fly   124 SLLRGSKFVFETGQGTVVEGLEVAVRSMRPYEQAEFIISYKLLFGELGCPPRIKPKADALFKVEV 188
            |..|...|||..|:|.|::..::.|.:|:..|....:...:..:|..|..|:|...|...|::|:
Human    70 SHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNATLFFEIEL 134

  Fly   189 IDYS--------------------------------------------------LIGDAK----- 198
            :|:.                                                  .:|:.:     
Human   135 LDFKGEDLFEDGGIIRRTKRKGEGYSNPNEGATVEIHLEGRCGGRMFDCRDVAFTVGEGEDHDIP 199

  Fly   199 -GID-AIPQEDRDKFCVVY------------PK-------------------------------- 217
             ||| |:.:..|::.|::|            ||                                
Human   200 IGIDKALEKMQREEQCILYLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEK 264

  Fly   218 ---AVDLHLHGKDSVKLGRYQSAATAFERAVSSLNYCRMANDEEERKQTELLTTLNQNLMIVYNK 279
               |..:...|....|.|:|..|...:.:.||.|......:::|.:.....|.....||.:.|.|
Human   265 LEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLK 329

  Fly   280 MNKPKRACIMMKALRHLTMGNPSCKALFQEGRALAALGEYNLARNAYLQAQAKQPANKEISDEII 344
            :.:..:|.........|...|.  |.|::.|.|...:.|:..|:..:.:.....|.||....:|.
Human   330 LREYTKAVECCDKALGLDSANE--KGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQIS 392

  Fly   345 SMNKRISKYEEASRDIWA---RAFSLKNSKSDVRKTPAQLEKEAKEQDFNDKMED 396
            ...|:..::.|..|.|:|   :.|:.:::|.:..|.   :.|:..|...|:|..|
Human   393 MCQKKAKEHNERDRRIYANMFKKFAEQDAKEEANKA---MGKKTSEGVTNEKGTD 444

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shuNP_611837.1 FKBP_C 96..189 CDD:278674 25/92 (27%)
TPR repeat 218..257 CDD:276809 9/38 (24%)
TPR repeat 262..295 CDD:276809 6/32 (19%)
TPR repeat 304..329 CDD:276809 6/24 (25%)
FKBP5NP_001139247.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24 4/16 (25%)
FKBP_C 43..135 CDD:278674 25/93 (27%)
TPR_11 267..347 CDD:290150 16/79 (20%)
TPR 1 268..301 9/32 (28%)
TPR repeat 268..296 CDD:276809 6/27 (22%)
TPR 2 317..350 6/32 (19%)
TPR_11 319..382 CDD:290150 13/64 (20%)
TPR 319..350 CDD:197478 6/30 (20%)
TPR repeat 319..345 CDD:276809 5/25 (20%)
TPR repeat 350..380 CDD:276809 7/31 (23%)
TPR 3 351..384 7/34 (21%)
TPR_1 352..384 CDD:278916 7/31 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 420..457 7/28 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0545
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.