DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shu and FKBP4

DIOPT Version :9

Sequence 1:	NP_611837.1	Gene:	shu / 45360	FlyBaseID:	FBgn0003401	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_002005.1	Gene:	FKBP4 / 2288	HGNCID:	3720	Length:	459	Species:	Homo sapiens

Alignment Length:	449	Identity:	98/449 - (21%)
Similarity:	161/449 - (35%)	Gaps:	126/449 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 DENIYKRITRTGHVDREAVPNKARVSVRYSGYWEGETAPFDSSLLRGSKFVFETGQGTVVEGLEV 146
            ||.:.|.|.|.| ...|......||.|.|:| |..:...|||||.|..||.|:.|:|.|::..::
Human    30 DEGVLKVIKREG-TGTEMPMIGDRVFVHYTG-WLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDI 92

  Fly   147 AVRSMRPYEQAEFIISYKLLFGELGCPPRIKPKADALFKVEVIDYS------------------- 192
            |:.:|:..|........:..:|..|.||:|.|.|..:|:||:.::.
Human    93 AIATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTR 157

  Fly   193 ---------------------------------LIGDAKGID-------AIPQEDRDKFCVVY-- 215
                                             .||:.:.:|       ||.:.::.:..:||
Human   158 GEGYAKPNEGAIVEVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLK 222

  Fly   216 ----------------PKA---VDLHL----HGKDS----------------------VKLGRYQ 235
                            |.|   .:|||    ..|:|                      .|.|:|:
Human   223 PSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYK 287

  Fly   236 SAATAFERAVSSLNYCRMANDEEERKQTELLTTLNQNLMIVYNKMNKPKRACIMMKALRHLTMGN 300
            .|...:::.||.|.|....::||.:|...|....:.||.:.:.|:.....|.........|...|
Human   288 QALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNN 352

  Fly   301 PSCKALFQEGRALAALGEYNLARNAYLQAQAKQPANKEISDEIISMNKRISKYEEASRDIWARAF 365
            .  |.||:.|.|..|:.::.|||..:.:.....|.||....::....:||.:.....:.::|..|
Human   353 E--KGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMF 415

  Fly   366 SLKNSKSDVRKTPAQLEKEAK-EQDFNDKMEDLIRRFKNTSDQQVSFSRKSYSNAQFDA 423
                      :..|:.|.:|| |....|...|     ....::|.|.:..|.|..:.:|
Human   416 ----------ERLAEEENKAKAEASSGDHPTD-----TEMKEEQKSNTAGSQSQVETEA 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shu	NP_611837.1	FKBP_C	96..189	CDD:278674	32/92 (35%)
		TPR repeat	218..257	CDD:276809	14/67 (21%)
		TPR repeat	262..295	CDD:276809	5/32 (16%)
		TPR repeat	304..329	CDD:276809	9/24 (38%)
FKBP4	NP_002005.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		FKBP_C	43..134	CDD:306713	31/91 (34%)
		FKBP_N	<155..254	CDD:332399	12/98 (12%)
		TPR_11	<250..>395	CDD:330823	32/146 (22%)
		Interaction with tubulin. /evidence=ECO:0000250	267..400		30/134 (22%)
		TPR repeat	274..301	CDD:276809	6/26 (23%)
		TPR repeat	306..348	CDD:276809	8/41 (20%)
		TPR repeat	353..381	CDD:276809	9/29 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	421..459		10/42 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810