DRSC/TRiP Functional Genomics Resources

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Protein Alignment shu and Ppp5c

DIOPT Version :9

Sequence 1:NP_611837.1 Gene:shu / 45360 FlyBaseID:FBgn0003401 Length:455 Species:Drosophila melanogaster
Sequence 2:NP_035285.2 Gene:Ppp5c / 19060 MGIID:102666 Length:499 Species:Mus musculus


Alignment Length:289 Identity:52/289 - (17%)
Similarity:94/289 - (32%) Gaps:95/289 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   174 PRIKPKADALFKVEVIDYSLIGDAKGIDAIPQEDRDKFCVVYPKAVDLHLHGKDSVKLGRYQSAA 238
            ||.:|.||...|                               :|.:|.....|..|...|::|.
Mouse    15 PRDEPPADGT
LK-------------------------------RAEELKTQANDYFKAKDYENAI 48

  Fly   239 TAFERAVSSLNYCRMANDEEERKQTELLTTLNQNLMIVYNKMNKP--KRAC---IMMKALRHLTM 298
            ..:.:|:.                      ||....|.|...:..  :..|   .:..|.|.:.:
Mouse    49 KFYSQAIE----------------------LNPGNAIYYGNRSLAYLRTECYGYALGDATRAIEL 91

  Fly   299 GNPSCKALFQEGRALAALGEYNLARNAYLQAQAKQPANKEISDEIISMNKRISKYEEASRDIWAR 363
            .....|..::...:..|||::..|...|......:|.:|:..          .||:|.|:.:..:
Mouse    92 DKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPNDKDAK----------MKYQECSKIVKQK 146

  Fly   364 AFSLKNSKSDVRKT---PAQLEKEAKEQDFNDK-----------MEDLIRRFKNTSDQQVSFSRK 414
            ||....:..:.|::   ...:|....|.:::..           |:||::.:|   ||:....:.
Mouse   147 AFERAIAGDEHRRSVVDSLDIESMTIEDEYSGPKLEDGKVTITFMKDLMQWYK---DQKKLHRKC 208

  Fly   415 SYSNAQF-----DATCKLAK--EHNLKLT 436
            :|   |.     :..|||:.  |..||.|
Mouse   209 AY---QILVQVKEVLCKLSTLVETTLKET 234

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shuNP_611837.1 FKBP_C 96..189 CDD:278674 6/14 (43%)
TPR repeat 218..257 CDD:276809 7/38 (18%)
TPR repeat 262..295 CDD:276809 6/37 (16%)
TPR repeat 304..329 CDD:276809 6/24 (25%)
Ppp5cNP_035285.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24 5/8 (63%)
TPR_11 27..93 CDD:290150 14/87 (16%)
TPR 1 28..61 9/54 (17%)
TPR 28..61 CDD:197478 9/54 (17%)
TPR repeat 28..56 CDD:276809 7/27 (26%)
TPR repeat 61..91 CDD:276809 5/29 (17%)
TPR 2 62..95 5/32 (16%)
TPR_9 71..134 CDD:290108 11/72 (15%)
TPR 3 96..129 7/32 (22%)
TPR_1 96..129 CDD:278916 7/32 (22%)
TPR repeat 96..124 CDD:276809 6/27 (22%)
MPP_PP5_C 176..491 CDD:277362 15/65 (23%)
Catalytic 184..499 15/57 (26%)
PP2Ac 204..480 CDD:197547 9/34 (26%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P53041 303..304
Required for autoinhibition. /evidence=ECO:0000250|UniProtKB:P53042 495..499
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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