DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shu and sgt-1

DIOPT Version :9

Sequence 1:	NP_611837.1	Gene:	shu / 45360	FlyBaseID:	FBgn0003401	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_494893.1	Gene:	sgt-1 / 173846	WormBaseID:	WBGene00019893	Length:	337	Species:	Caenorhabditis elegans

Alignment Length:	427	Identity:	88/427 - (20%)
Similarity:	153/427 - (35%)	Gaps:	121/427 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEENFEPYTPQL-LKNPLSYSD---LVKKGVEFEVDNSQQNHARDLGLDSDSDSDYEDALDVDGE 61
            |.|..:|..|.. ..:|:...|   ||...::|......||.|         .::..:||:|..:
Worm     1 MSEEIKPSAPDAPTASPIVTRDEQNLVVSFLQFIRQKVSQNQA---------TAEQAEALEVAIQ 56

  Fly    62 ELRSPW-----TYSFDELRALMSEIDENIYKRITRTGHVDREAVPNKARVSVRYSGYWEGETA-- 119
            .|...:     :|:|...|.::     .::|        ..|.:|             |||:|
Worm    57 CLEHSFGLDDASYAFQPSRPIL-----ELFK--------SAEGLP-------------EGESALP 95

  Fly   120 -PFDSSLLRGSKFVFETGQGTVVEGLEVAVRSMRPYEQAEFIISYKLLFGELGCPPRIKPKADAL 183
             |.||.:.:.:|...|..........|.||:.   |..|..:....:.|    |     .:|.|.
Worm    96 TPSDSDISQANKLKEEGNDLMKASQFEAAVQK---YNAAIKLNRDPVYF----C-----NRAAAY 148

  Fly   184 FKVEVIDYSLIGDAKGIDAIPQEDRDKFCVVYPKAVDLHLHGKDSVKL---GRYQSAATAFERAV 245
            .::|..|.: |.|.:...|:...        |.||     .|:..:..   .||:.||.|:::|:
Worm   149 CRLEQYDLA-IQDCRTALALDPS--------YSKA-----WGRMGLAYSCQNRYEHAAEAYKKAL 199

  Fly   246 SSLNYCRMANDEEERKQTELLTTLNQNLMIVYNKM-----NKPKRACIMMKALRHLTMGNPSCKA 305
                  .:..::|..|         .||.|..:|:     ::|......:..|.....|.|
Worm   200 ------ELEPNQESYK---------NNLKIAEDKLKELESSRPAPGANPLAGLLGAMGGGP---- 245

  Fly   306 LFQEGRALAALGEYNLARNAYLQAQAKQPANKEISDEIISMNKRISKYEEASRDIWARAFSLKNS 370
                |...|..|..|: :|...:....|.|::.:||..:|             |::....|...|
Worm   246 ----GGMPAMPGMPNM-QNLMNEPGLMQAASQMMSDPALS-------------DMFNNMMSGNGS 292

  Fly   371 KSDVRKTPAQLEKEAKEQDFNDKM-EDLIRRFKNTSD 406
            .:|:.....|:  .|:.|:.|.:: |:|.|:|...:|
Worm   293 IADLMAAGQQM--AARMQETNPELIENLRRQFGPGAD 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shu	NP_611837.1	FKBP_C	96..189	CDD:278674	21/95 (22%)
		TPR repeat	218..257	CDD:276809	8/41 (20%)
		TPR repeat	262..295	CDD:276809	6/37 (16%)
		TPR repeat	304..329	CDD:276809	5/24 (21%)
sgt-1	NP_494893.1	SGTA_dimer	25..83	CDD:293154	14/79 (18%)
		TPR_11	104..169	CDD:290150	16/77 (21%)
		TPR repeat	105..133	CDD:276809	7/30 (23%)
		TPR_11	137..203	CDD:290150	19/94 (20%)
		TPR repeat	137..167	CDD:276809	8/39 (21%)
		TPR	138..171	CDD:197478	9/50 (18%)
		TPR_1	172..204	CDD:278916	9/42 (21%)
		TPR repeat	172..200	CDD:276809	9/38 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910