DRSC/TRiP Functional Genomics Resources

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Protein Alignment shu and Fkbp5

DIOPT Version :9

Sequence 1:NP_611837.1 Gene:shu / 45360 FlyBaseID:FBgn0003401 Length:455 Species:Drosophila melanogaster
Sequence 2:NP_034350.1 Gene:Fkbp5 / 14229 MGIID:104670 Length:456 Species:Mus musculus


Alignment Length:427 Identity:82/427 - (19%)
Similarity:155/427 - (36%) Gaps:119/427 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 DENIYKRITRTGHVDREAVPNKARVSVRYSGYWEGETAPFDSSLLRGSKFVFETGQGTVVEGLEV 146
            |..:.|.:.|.|..| ||.....:|.|.|.|.. .:...||||..|...|.|..|||.|::..::
Mouse    30 DRGVLKIVKRVGTSD-EAPMFGDKVYVHYKGML-SDGKKFDSSHDRKKPFAFSLGQGQVIKAWDI 92

  Fly   147 AVRSMRPYEQAEFIISYKLLFGELGCPPRIKPKADALFKVEVIDYS------------------- 192
            .|.:|:..|....:...:..:|..|...:|...|...|::|::|:.                   
Mouse    93 GVSTMKKGEICHLLCKPEYAYGSAGHLQKIPSNATLFFEIELLDFKGEDLFEDSGVIRRIKRKGE 157

  Fly   193 -------------------------------LIGDAK------GID-AIPQEDRDKFCVVY---- 215
                                           ::|:.:      ||| |:.:..|::.|::|    
Mouse   158 GYSNPNEGATVKVHLEGCCGGRTFDCRDVVFVVGEGEDHDIPIGIDKALVKMQREEQCILYLGPR 222

  Fly   216 --------PK-AVDLHLH------------GKDS----------------------VKLGRYQSA 237
                    || .:|.:..            .|:|                      .|.|:|..|
Mouse   223 YGFGEAGKPKFGIDPNAELMYEVTLKSFEKAKESWEMDTKEKLTQAAIVKEKGTVYFKGGKYTQA 287

  Fly   238 ATAFERAVSSLNYCRMANDEEERKQTELLTTLNQNLMIVYNKM---NKPKRACIMMKALRHLTMG 299
            ...:.:.||.|......:::|.:.....|.....||.:.|.|:   ||....|.     :.|.:.
Mouse   288 VIQYRKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYNKAVECCD-----KALGLD 347

  Fly   300 NPSCKALFQEGRALAALGEYNLARNAYLQAQAKQPANKEISDEIISMNKRISKYEEASRDIWA-- 362
            :.:.|.|::.|.|...:.::..|:..:.:..|..|.|:....:|....::..::.|..|.::|  
Mouse   348 SANEKGLYRRGEAQLLMNDFESAKGDFEKVLAVNPQNRAARLQISMCQRKAKEHNERDRRVYANM 412

  Fly   363 -RAFSLKNSKSDVRKTPAQ--LEKEAKEQDFNDKMED 396
             :.|:.:::|.:..|..::  :|..|.:|..:..||:
Mouse   413 FKKFAERDAKEEASKAGSKKAVEGAAGKQHESQAMEE 449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shuNP_611837.1 FKBP_C 96..189 CDD:278674 27/92 (29%)
TPR repeat 218..257 CDD:276809 10/72 (14%)
TPR repeat 262..295 CDD:276809 8/35 (23%)
TPR repeat 304..329 CDD:276809 5/24 (21%)
Fkbp5NP_034350.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
FKBP_C 44..135 CDD:278674 27/92 (29%)
TPR_11 267..347 CDD:290150 17/84 (20%)
TPR 1 268..301 7/32 (22%)
TPR repeat 268..296 CDD:276809 4/27 (15%)
TPR 2 317..350 8/37 (22%)
TPR_11 319..382 CDD:290150 14/67 (21%)
TPR 319..350 CDD:197478 8/35 (23%)
TPR repeat 319..345 CDD:276809 7/30 (23%)
TPR repeat 350..380 CDD:276809 5/29 (17%)
TPR 3 351..384 7/32 (22%)
TPR_1 352..384 CDD:278916 7/31 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 421..456 7/29 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0545
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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