DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shu and FKBP9

DIOPT Version :9

Sequence 1:	NP_611837.1	Gene:	shu / 45360	FlyBaseID:	FBgn0003401	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001271270.1	Gene:	FKBP9 / 11328	HGNCID:	3725	Length:	623	Species:	Homo sapiens

Alignment Length:	373	Identity:	77/373 - (20%)
Similarity:	126/373 - (33%)	Gaps:	96/373 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 DVDGEELRSPWTYSFDELRALMSEIDENIYKRITRTGHVDREAVP-NKARVS-----VRYSGYWE 115
            |.||:::....:..||.....:....::|        .::.:.|| |..|:|     :||  ::.
Human   285 DGDGKDIPGQASLVFDVALLDLHNPKDSI--------SIENKVVPENCERISQSGDFLRY--HYN 339

  Fly   116 G---ETAPFDSSLLRGSKFVFETGQGTVVEGLEVAVRSMRPYEQAEFIISYKLLFGELGCPPRIK 177
            |   :...||||..|...|....|||.|:.|::..:..:...|:...::...|.:||.| ...|.
Human   340 GTLLDGTLFDSSYSRNRTFDTYIGQGYVIPGMDEGLLGVCIGEKRRIVVPPHLGYGEEG-RGNIP 403

  Fly   178 PKADALFKVEVIDYSLIGDAKGIDAIPQEDRDKFCVVYPKAVD-LHLH----------------- 224
            ..|..:|.:.|||:....|:   .:|....:...|.|..|..| |..|
Human   404 GSAVLVFDIHVIDFHNPSDS---ISITSHYKPPDCSVLSKKGDYLKYHYNASLLDGTLLDSTWNL 465

  Fly   225 --------GKDSVKLGR---YQSAATAFERAV---SSLNYCRMANDEE---------ERKQTELL 266
                    |...|.||.   .:......:|.|   ..|.|.....|.|         :.:..||:
Human   466 GKTYNIVLGSGQVVLGMDMGLREMCVGEKRTVIIPPHLGYGEAGVDGEVPGSAVLVFDIELLELV 530

  Fly   267 TTLNQNLMIVYNKMNKPKRACIMMKALRHLTMGNPSCKALFQE----GRALAALGEYNLARNAYL 327
            ..|.:..|.::|....|.                     ||:|    |.....|.|:    :.|:
Human   531 AGLPEGYMFIWNGEVSPN---------------------LFEEIDKDGNGEVLLEEF----SEYI 570

  Fly   328 QAQAKQPANK---EISDEIISMNKRISKYEEASRDIWARAFSLKNSKS 372
            .||......|   ....|:|..|...::.......:.|..|.||:.::
Human   571 HAQVASGKGKLAPGFDAELIVKNMFTNQDRNGDGKVTAEEFKLKDQEA 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shu	NP_611837.1	FKBP_C	96..189	CDD:278674	27/101 (27%)
		TPR repeat	218..257	CDD:276809	11/70 (16%)
		TPR repeat	262..295	CDD:276809	6/32 (19%)
		TPR repeat	304..329	CDD:276809	7/28 (25%)
FKBP9	NP_001271270.1	FKBP_C	47..191	CDD:278674
		FKBP_C	212..304	CDD:278674	5/18 (28%)
		FKBP_C	324..415	CDD:278674	24/93 (26%)
		FKBP_C	435..527	CDD:278674	16/91 (18%)
		EF-hand_7	548..612	CDD:290234	14/88 (16%)
		EFh	550..611	CDD:238008	13/64 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810