DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pk and LPXN

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_001137467.1	Gene:	LPXN / 9404	HGNCID:	14061	Length:	391	Species:	Homo sapiens

Alignment Length:	183	Identity:	57/183 - (31%)
Similarity:	78/183 - (42%)	Gaps:	18/183 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   648 SWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAETLKPRCSACDEIILADECTEAEGRAWHMN 712
            ||||..|.|:.|:|.:....:|.|.|..||...:.:...|||:.|...|| |:...|..:.||..
Human   175 SWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPRCAYCAAPIL-DKVLTAMNQTWHPE 238

  Fly   713 HFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQHWHATDECF 777
            ||.|..|.:..|.:.:..::.||||...|.|||:..|..|...  |.:..:|.....||  .|||
Human   239 HFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRP--VLENYLSAMDTVWH--PECF 299

  Fly   778 SCNTCRCSLLGRAFLPRRGAIYCSI-----------ACSKGEPPTPSDSSGTG 819
            .|..|..|....:|....|..:|.:           .|  |:|.|....|..|
Human   300 VCGDCFTSFSTGSFFELDGRPFCELHYHHRRGTLCHGC--GQPITGRCISAMG 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602
		LIM1_Prickle	624..682	CDD:188799	13/33 (39%)
		LIM2_Prickle	687..742	CDD:188802	19/54 (35%)
		LIM3_Prickle	747..805	CDD:188804	15/68 (22%)
LPXN	NP_001137467.1	LIM1_Leupaxin	155..209	CDD:188790	13/33 (39%)
		LIM2_Leupaxin	216..267	CDD:188792	17/51 (33%)
		LIM3_Leupaxin	275..327	CDD:188794	15/55 (27%)
		LIM4_Paxillin_like	334..385	CDD:188725	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593918at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920