DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pk and LIMD1

DIOPT Version :9

Sequence 1:NP_724538.1 Gene:pk / 45343 FlyBaseID:FBgn0003090 Length:1299 Species:Drosophila melanogaster
Sequence 2:NP_055055.1 Gene:LIMD1 / 8994 HGNCID:6612 Length:676 Species:Homo sapiens


Alignment Length:659 Identity:154/659 - (23%)
Similarity:224/659 - (33%) Gaps:201/659 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   249 APKPALPPKQKQQRPVPPLPPPPANRVTQDQGT-------------QPAAPQVPLQPLTAGDLQF 300
            |.:|..||::::.||.    .......:||.|:             ||...:.| ..||.|| .:
Human   122 AGQPPYPPQEQRSRPY----LHGTRHGSQDCGSRESLATSEMSAFHQPGPCEDP-SCLTHGD-YY 180

  Fly   301 LNLSLRQ-------------------------RSLPRSMKPFKDAHDISFTFNELDTSAEPEVA- 339
            .||||..                         .|.|...||..| |.::.....|.:|...|.: 
Human   181 DNLSLASPKWGDKPGVSPSIGLSVGSGWPSSPGSDPPLPKPCGD-HPLNHRQLSLSSSRSSEGSL 244

  Fly   340 ----TGAAQQESNEPISRTPLTQISYLQKI-PTLPRHFSPSGQGLATPPALGSGGMGLPSSSSAS 399
                :|...:.|.:|   |.|...:..|:: |.||   ||:.:..|  ||:|......||.|:..
Human   245 GGQNSGIGGRSSEKP---TGLWSTASSQRVSPGLP---SPNLENGA--PAVGPVQPRTPSVSAPL 301

  Fly   400 ALYAAQAAAGILPTS------------------PLPLQRH--QQYLPPHHQQHPGAGMGPGPGSG 444
            ||...:  .|.||.|                  |.|..:.  :.||.........||:   .||.
Human   302 ALSCPR--QGGLPRSNSGLGGEVSGVMSKPNVDPQPWFQDGPKSYLSSSAPSSSPAGL---DGSQ 361

  Fly   445 AAAGPPLGPQYSPGCS---ANPKYSNAQLPPPPHHHHQLSPALSTPSPPSLLHHPAGGTSSASAH 506
            ..|.|.|||:  |||:   ..||.|...|         :.|.:||....|....|.|.:|..|..
Human   362 QGAVPGLGPK--PGCTDLGTGPKLSPTSL---------VHPVMSTLPELSCKEGPLGWSSDGSLG 415

  Fly   507 APFLGGPHMDMQRQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQYRVR 571
            :..|..|                                                :||    |||
Human   416 SVLLDSP------------------------------------------------SSP----RVR 428

  Fly   572 QLLHQLPPHDNEVRYCHSLTDEERKELRLFSTQRKRDALGRGNVRQLMSARP-------CDGCDD 629
                 ||        |..|.  ...|||..:.:.|.:||.:...|: |.|.|       |..|  
Human   429 -----LP--------CQPLV--PGPELRPSAAELKLEALTQRLERE-MDAHPKADYFGACVKC-- 475

  Fly   630 LISTGDIAVFATRLGPNAS---WHPACFACSVCRELLVDLIYFHRDGRMYCGRHHA----ETLKP 687
              |.|   ||.......|.   :|..||.|:.|...|....::..:|:::|.....    :....
Human   476 --SKG---VFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSAD 535

  Fly   688 RCSACDEIILADECTEAEGRAWHMNHFACHECDKQLGGQRY-IMREGKPYCLHCFDAMFAEYCDY 751
            ||..|..:|: |...:|.|:::|...|.|..|::.|.|..: :..|.|.||:..:..:.|..|..
Human   536 RCFLCGHLIM-DMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAA 599

  Fly   752 CGEAIGVDQGQ------MSHDGQHWHATDECFSCNTCRCSLL---GRAFLPRRGAIYCSIACSKG 807
            ||..|...:|.      :|.| :.:|.  ||:.|..|...|.   |....|....::|.....|.
Human   600 CGLPILPPEGSDETIRVVSMD-RDYHV--ECYHCEDCGLELNDEDGHRCYPLEDHLFCHSCHVKR 661

  Fly   808 EPPTPSDSS 816
            ....||.::
Human   662 LEKRPSSTA 670

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pkNP_724538.1 PET_Prickle 523..618 CDD:193602 16/94 (17%)
LIM1_Prickle 624..682 CDD:188799 15/60 (25%)
LIM2_Prickle 687..742 CDD:188802 17/55 (31%)
LIM3_Prickle 747..805 CDD:188804 16/66 (24%)
LIMD1NP_055055.1 Mediates nuclear export 54..134 4/11 (36%)
Atrophin-1 <69..443 CDD:331285 95/418 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 104..163 9/44 (20%)
Interaction with EGLN1/PHD2 186..260 12/77 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 189..389 53/224 (24%)
Interaction with RB1. /evidence=ECO:0000269|PubMed:15542589 404..442 17/104 (16%)
Necessary for nuclear localization 472..676 52/210 (25%)
LIM1_Ajuba_like 472..525 CDD:188738 15/59 (25%)
LIM2_Ajuba_like 537..589 CDD:188741 16/52 (31%)
LIM3_Ajuba_like 597..658 CDD:188822 16/63 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1704
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.