DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pk and Ajuba

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_445955.1	Gene:	Ajuba / 85265	RGDID:	620407	Length:	548	Species:	Rattus norvegicus

Alignment Length:	721	Identity:	160/721 - (22%)
Similarity:	233/721 - (32%)	Gaps:	239/721 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 RSKKLLRSLRAHVRGE-KLPKNDTTTANESSEVT--QRNARVTVLDDPFLFGIDADHLGDLVVRG 209
            ::.:||..||....|. |..:.....:...|:.|  ....|::.|..|...|    |.|  ...|
  Rat     7 KASRLLEKLRLSDSGSAKFGRRKGEASRSGSDGTPGAGKGRLSGLGGPRKSG----HRG--ANGG 65

  Fly   210 KRYSTLDATENMARFYAEQEATAQVLEIIEQEEESPEQEAPKPALPPKQKQQRPVP-PLPPPPAN 273
            .....|:.........||:.|....        |:...|...|..||   ..|.:| ||..||..
  Rat    66 PGDEALEPAREQGPLDAERNARGSF--------EAQRFEGSFPGGPP---PTRALPLPLSSPPDF 119

  Fly   274 RVTQDQGTQPAAPQVPLQPLTAGDLQFLNLSLRQRSLPRSMKPFKDAHDISFTFNELDTSAEPEV 338
            |:   :.|.||                  ||      |||          ||..:....:::|..
  Rat   120 RL---ETTAPA------------------LS------PRS----------SFASSSASDASKPSS 147

  Fly   339 --------ATGAAQQESNEPIS-RTPLTQISYLQKIPTLPRHFSPSGQGLATPPALGSGGMGLPS 394
                    ..||:....:.|.| ||....:.|.|      ||.||    |...|.|    .|||.
  Rat   148 PRGSLLLDGAGASGAGGSRPCSNRTSGISMGYDQ------RHGSP----LPAGPCL----FGLPL 198

  Fly   395 SSSASALYAAQAAAGILPTSPLPLQRHQQYLP-------PHHQQHPGAGMGPGPGSGAAAGP--P 450
            :::.|. |::.......|.....|.|...:.|       ..|...|..| .||..:||..|.  |
  Rat   199 TTAPSG-YSSGGVPSAYPELHAALDRLCAHRPVGFGCQESRHSYPPALG-SPGALTGAVVGTAGP 261

  Fly   451 L---GPQYSPG---------CSANPKYSNAQLPPPPHHHHQLSPALSTPSPPSLLHHPAGGTSSA 503
            |   |.|  ||         |:|..:|.:           :|:..|.       |....||..:.
  Rat   262 LERRGTQ--PGRHSVTGYGDCAAGARYQD-----------ELTALLR-------LTVATGGREAG 306

  Fly   504 SAHAPFLGGPHMDMQRQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQY 568
            :...| ||            .:.||  |||    .||          |.:|:         ..:.
  Rat   307 ARGEP-LG------------IEPSG--LEE----SPG----------SFVPE---------ASRS 333

  Fly   569 RVRQLLHQLPPHDNEVRYCHSLTDEERKELRLFSTQRK--RDALGRGNVRQLMSARPCDGCDDLI 631
            |:|:                   .|.|::  .|.|..|  :...|:.|.        |...|.|
  Rat   334 RIRE-------------------PEARED--YFGTCIKCNKGIYGQSNA--------CQALDSL- 368

  Fly   632 STGDIAVFATRLGPNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHA----ETLKPRCSAC 692
                             :|..||.|..|...|....::..:|.:||...:.    :....:|..|
  Rat   369 -----------------YHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDYLFSGFQEAAEKCCVC 416

  Fly   693 DEIILADECTEAEGRAWHMNHFACHECDKQLGGQRYIMR-EGKPYCLHCFDAMFAEYCDYCGEAI 756
            ..:|| ::..:|.|:::|...|.|..|:|.|.|..:.:. ..:.||:..:...:|..|..||:.|
  Rat   417 GHLIL-EKILQAMGKSYHPGCFRCIVCNKCLDGVPFTVDFSNQVYCVTDYHKNYAPKCAACGQPI 480

  Fly   757 GVDQG--------QMSHDGQHWHATDECFSCNTCRCSLL---GRAFLPRRGAIYCSIAC-----S 805
            ...:|        .|..|   :|.  ||:.|..||..|.   |....|..|.:.|. .|     |
  Rat   481 LPSEGCEDIVRVISMDRD---YHF--ECYHCEDCRMQLSDEEGCCCFPLDGHLLCH-GCHMQRLS 539

  Fly   806 KGEPPT 811
            ..:|||
  Rat   540 ARQPPT 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	18/96 (19%)
		LIM1_Prickle	624..682	CDD:188799	12/57 (21%)
		LIM2_Prickle	687..742	CDD:188802	15/55 (27%)
		LIM3_Prickle	747..805	CDD:188804	19/73 (26%)
Ajuba	NP_445955.1	PreLIM	1..345		104/486 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..182		50/234 (21%)
		Nuclear localization signal. /evidence=ECO:0000255	290..298		3/14 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..333		12/63 (19%)
		LIM1_Ajuba_like	348..401	CDD:188738	15/78 (19%)
		LIM2_Ajuba_like	413..465	CDD:188741	15/52 (29%)
		LIM3_Ajuba_like	473..534	CDD:188822	18/66 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900