DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pk and RGA2

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_010667.1	Gene:	RGA2 / 851985	SGDID:	S000002787	Length:	1009	Species:	Saccharomyces cerevisiae

Alignment Length:	743	Identity:	151/743 - (20%)
Similarity:	243/743 - (32%)	Gaps:	237/743 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   689 CSACDEIILADECTEAEGRAWHMNHFACHECDKQLGGQR--YIMREGKPYCLHCFDAMFAEYCDY 751
            |..|::.|.:.:..|.|.:.||...|.|::|||:|....  .::..|...|..|.|.     |..
Yeast    13 CVRCNKSIASSQVYELESKKWHDQCFTCYKCDKKLNADSDFLVLDIGTLICYDCSDK-----CTN 72

  Fly   752 CGEAIGVDQGQMSHDGQHWHATDECFSCNTCRCS--LLGRAFL-PRRGAIYCSIACSKG------ 807
            ||:.|  |...:.....:......||.|  ||||  :....:. .:||  .|.:.|.:.
Yeast    73 CGDKI--DDTAIILPSSNEAYCSNCFRC--CRCSNRIKNLKYAKTKRG--LCCMDCHEKLLRKKQ 131

  Fly   808 ---EPPTPSDSSGTGMYTTPTPPTQRVRPHPQAPL-PARIPSS---------------HASSSPP 853
               |..|.:.|........|....:|       || |.||...               .::....
Yeast   132 LLLENQTKNSSKEDFPIKLPERSVKR-------PLSPTRINGKSDVSTNNTAISKNLVSSNEDQQ 189

  Fly   854 MSPQ---QQQQHQATFNQAMYQMQSQQMEAAGGLVDQSKSYAASDSDAGVVKD-LEHGGHMGGGD 914
            ::||   .|::.:::.|.......|:..|       ::.|:|.:.|...::.. |||
Yeast   190 LTPQVLVSQERDESSLNDNNDNDNSKDRE-------ETSSHARTVSIDDILNSTLEH-------- 239

  Fly   915 LTDFSGGRASSTSQNLSPLNSPGDFQPHFLPKPMELQRDGVY-------NFNEMSSNLDAAWSAK 972
              |.:.....|...|...:|..|:...:.|.||....||.:.       |.|..::...:.:..:
Yeast   240 --DSNSIEEQSLVDNEDYINKMGEDVTYRLLKPQRANRDSIVVKDPRIPNSNSNANRFFSIYDKE 302

  Fly   973 PT---NSYHLQRQLLENPHTASMPELAGKLVAP----------PAH------------------- 1005
            .|   ::.:.:.:::.|....|..::...|.:|          |.|
Yeast   303 ETDKDDTDNKENEIIVNTPRNSTDKITSPLNSPMAVQMNEEVEPPHGLALTLSEATKENNKSSQG 367

  Fly  1006 --------MQHL-----------------SQLHAVSSHQFQQHEYADILHP----PPPPPGEIP- 1040
                    |.|:                 |.|....:..|.:.:.||.|.|    .|.|..::.
Yeast   368 IQTSTSKSMNHVSPITRTDTVEMKTSTSSSTLRLSDNGSFSRPQTADNLLPHKKVAPSPNKKLSR 432

  Fly  1041 --ELPTPNL-----SVASTALPPE-------LMGSPTHSA-GDRSLNTPMSTQSASHAPPHPVSI 1090
              .|.:.|.     |..|..|.|:       :..|.|||. |..|.:|.:   ..|.|..:|||
Yeast   433 SFSLKSKNFVHNLKSKTSEMLDPKHPHHSTSIQESDTHSGWGVSSTHTNI---RKSKAKKNPVS- 493

  Fly  1091 LSGASSSSPMSGEPAKKKGVRFEGIPDTLPRSRS-----YSGNGAGTSGGGERERDRDKDKEGGG 1150
             .|.|.|:                |.:|||:..:     ::...|.:|.|...::....|.....
Yeast   494 -RGQSDST----------------IYNTLPQHGNFTVPEFNHKKAQSSLGSISKKQNSNDTATNR 541

  Fly  1151 R---------HGHGHSSRRR----------RRRKSSSSSSHHRSGSGHRSHST--------TRAD 1188
            |         .|| |.:..|          :|...||.|:||||.|...|.||        |:.|
Yeast   542 RINGSFTSSSSGH-HIAMFRTPPLESGPLFKRPSLSSESAHHRSSSLQTSRSTNALLEDDSTKVD 605

  Fly  1189 -TYAPAQPLSSSYQGPPSVLQAANL-VHESPSRQQ------------------------RERERE 1227
             |...|..|...:......|:...| |.|....::                        ||::::
Yeast   606 ATDESATSLEKDFYFTELTLRKLKLDVRELEGTKKKLLQDVENLRLAKERLLNDVDNLTREKDKQ 670

  Fly  1228 ----REREESEESDVCSTCSSSSSSSED 1251
                ||..|.:|:...|....|.||:.|
Yeast   671 SASSRESLEQKENIATSITVKSPSSNSD 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602
		LIM1_Prickle	624..682	CDD:188799
		LIM2_Prickle	687..742	CDD:188802	16/54 (30%)
		LIM3_Prickle	747..805	CDD:188804	15/60 (25%)
RGA2	NP_010667.1	LIM1_Rga	13..67	CDD:188780	15/53 (28%)
		LIM2_Rga	70..123	CDD:188781	15/58 (26%)
		RhoGAP	815..1002	CDD:214618
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900