DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pk and AJUBA

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_116265.1	Gene:	AJUBA / 84962	HGNCID:	20250	Length:	538	Species:	Homo sapiens

Alignment Length:	639	Identity:	142/639 - (22%)
Similarity:	204/639 - (31%)	Gaps:	231/639 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 KRYSTLDATENMARFYAEQEATAQVLEIIEQEEESPEQEAPKPALPPKQKQQRPVPPLPPPPANR 274
            :...:|||..|....:                 |:|..|...||.||..: ..|:|...||
Human    65 REQGSLDAERNQRGSF-----------------EAPRYEGSFPAGPPPTR-ALPLPQSLPP---- 107

  Fly   275 VTQDQGTQPAAPQVPLQPLTAGDLQFLNLSLRQRSLPRSMKPFKDAHDISFTFNELDTSAEPEV- 338
               |...:|.||.:.                     |||          ||..:....:::|..
Human   108 ---DFRLEPTAPALS---------------------PRS----------SFASSSASDASKPSSP 138

  Fly   339 -------ATGAAQQESNEPIS-RTPLTQISYLQKIPTLPRHFS--PSGQGLATPPALG-----SG 388
                   ..||.....:.|.| ||....:.|.|      ||.|  |:|..|..||..|     |.
Human   139 RGSLLLDGAGAGGAGGSRPCSNRTSGISMGYDQ------RHGSPLPAGPCLFGPPLAGAPAGYSP 197

  Fly   389 GMGLPSS-----SSASALYAAQAAAGILPTSPLPLQRHQQYLPPHHQQHPGAGMGPGPGSGAAAG 448
            | |:||:     ::...|| ||..||      ...|..:...|| ....|||..|.|.|   |||
Human   198 G-GVPSAYPELHAALDRLY-AQRPAG------FGCQESRHSYPP-ALGSPGALAGAGVG---AAG 250

  Fly   449 PPLGPQYSPG---------CSANPKYSNAQLPPPPHHHHQLSPALSTPSPPSLLHHPAGGTSSAS 504
            |.......||         |:...:|.:           :|:         :||....|
Human   251 PLERRGAQPGRHSVTGYGDCAVGARYQD-----------ELT---------ALLRLTVG------ 289

  Fly   505 AHAPFLGGPHMDMQRQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQYR 569
                 .||.....:.:....:.||  |||    |||                  |:|   .|..|
Human   290 -----TGGREAGARGEPSGIEPSG--LEE----PPG------------------PFV---PEAAR 322

  Fly   570 VRQLLHQLPPHDNEVRYCHSLTDEERKELRLFSTQRK--RDALGRGNVRQLMSARPCDGCDDLIS 632
            .|                  :.:.|.:| ..|.|..|  :...|:.|.        |...|.|
Human   323 AR------------------MREPEARE-DYFGTCIKCNKGIYGQSNA--------CQALDSL-- 358

  Fly   633 TGDIAVFATRLGPNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHA----ETLKPRCSACD 693
                            :|..||.|..|...|....::..:|.:||...:.    :....:|..|.
Human   359 ----------------YHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDYLFSGFQEAAEKCCVCG 407

  Fly   694 EIILADECTEAEGRAWHMNHFACHECDKQLGGQRYIMR-EGKPYCLHCFDAMFAEYCDYCGEAIG 757
            .:|| ::..:|.|:::|...|.|..|:|.|.|..:.:. ..:.||:..:...:|..|..||:.|.
Human   408 HLIL-EKILQAMGKSYHPGCFRCIVCNKCLDGIPFTVDFSNQVYCVTDYHKNYAPKCAACGQPIL 471

  Fly   758 VDQG--------QMSHDGQHWHATDECFSCNTCRCSLL---GRAFLPRRGAIYC 800
            ..:|        .|..|   :|.  ||:.|..||..|.   |....|..|.:.|
Human   472 PSEGCEDIVRVISMDRD---YHF--ECYHCEDCRMQLSDEEGCCCFPLDGHLLC 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	20/96 (21%)
		LIM1_Prickle	624..682	CDD:188799	12/57 (21%)
		LIM2_Prickle	687..742	CDD:188802	15/55 (27%)
		LIM3_Prickle	747..805	CDD:188804	18/65 (28%)
AJUBA	NP_116265.1	PreLIM	1..335		91/420 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..172		33/168 (20%)
		PHA03418	<18..>103	CDD:177646	12/55 (22%)
		Nuclear localization signal. /evidence=ECO:0000255	280..288		3/16 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..315		10/47 (21%)
		LIM1_Ajuba_like	338..391	CDD:188738	15/78 (19%)
		LIM2_Ajuba_like	403..455	CDD:188741	15/52 (29%)
		LIM3_Ajuba_like	463..524	CDD:188822	18/63 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810