DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pk and prickle2a

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_001071251.2	Gene:	prickle2a / 777736	ZFINID:	ZDB-GENE-061110-112	Length:	869	Species:	Danio rerio

Alignment Length:	946	Identity:	336/946 - (35%)
Similarity:	439/946 - (46%)	Gaps:	253/946 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   516 DMQRQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQYRVRQLLHQLPPH 580
            |.||.|.||||||||||||.||||||:|:||..|:...|:||||||||.||::|::|||.|||||
Zfish    15 DFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYRFFPEDKVPYVNSIGEKHRIKQLLQQLPPH 79

  Fly   581 DNEVRYCHSLTDEERKELRLFSTQRKRDALGRGNVRQL---MSARPCDGCDDLISTGDIAVFATR 642
            |||||||.||.:||::||::||.|||||.||||.||.|   ::...|..|.:.|..|||||||:|
Zfish    80 DNEVRYCTSLDEEEKRELKIFSNQRKRDNLGRGTVRPLPLTITGAICQQCGEQIKGGDIAVFASR 144

  Fly   643 LGPNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAETLKPRCSACDEIILADECTEAEGR 707
            :.....|||.||.|.||.|||||||||..:|::||||||||.||||||||||||.|||||||||:
Zfish   145 VAHGLCWHPHCFVCGVCSELLVDLIYFQLEGKIYCGRHHAERLKPRCSACDEIIFADECTEAEGQ 209

  Fly   708 AWHMNHFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQHWHA 772
            .|||.||.|:||:..|||||||||||.|:|.:||:.::|||||.|||.||:|||||:::||||||
Zfish   210 HWHMKHFCCYECEAPLGGQRYIMREGHPHCCNCFENLYAEYCDSCGEHIGIDQGQMTYEGQHWHA 274

  Fly   773 TDECFSCNTCRCSLLGRAFLPRRGAIYCSIACSKGEPPTPSDSS--------------------- 816
            |::||||..|..|||||.|||::|.||||..||:|:....||||
Zfish   275 TEDCFSCARCSQSLLGRPFLPKQGLIYCSRLCSQGDEAELSDSSDSAFQSARSRQSHHSASVGKD 339

  Fly   817 ---GTG---MYTTPTPPTQRVRPHPQA----------PLPARIPSSHASSSPPMSPQQQQQHQAT 865
               |.|   ..|:..|.|......|.|          |.|:|.|    ..:|..:|.:......:
Zfish   340 GSKGKGEAVRQTSSGPTTLSGDAEPLAVQMDLLSVASPAPSRTP----HRTPTRTPSRTSSRSPS 400

  Fly   866 FN--QAMYQMQSQQMEAAGGLVDQSKSYAASDSDAGVVKDLEHGGHMGGGDLTDFSGGRASSTSQ 928
            .|  |.::             |::.:.|:                         :...|.||||.
Zfish   401 LNREQTVW-------------VNRDEPYS-------------------------YESQRDSSTSP 427

  Fly   929 NLSPLNSPGDFQPHFLPKPMELQRDGVYNFNEMSSNLDAAWSAKPTNSYHLQRQLL--------- 984
            |...|.|....:..:.|.|.  |...:.:..|       |||.:|......:..::
Zfish   428 NPHQLRSQCSIRTAYPPSPN--QPPKIVSSQE-------AWSKEPPGGNSKKPPVMAALRGHSFN 483

  Fly   985 EN-PHTASMPELAGKLVAPPAHMQHLSQLHAVSS----------------------------HQF 1020
            || .|....||.     .||.....:| .:.|||                            |||
Zfish   484 ENWMHHGQEPEF-----HPPKLKTQMS-FNEVSSRNSGFLDKRSISVQGFPREMRPLLLRGRHQF 542

  Fly  1021 QQHEYADILHPPPPPPGEIPEL-PTPNLSVASTALP----------------------PELMGSP 1062
            :            |..||:..| .||..|..|.||.                      |:|....
Zfish   543 R------------PNFGELTPLEQTPRGSADSLALSYTTGNSLDGTSRRQEHFSRFSMPDLSKDS 595

  Fly  1063 THSAGDR----SLNTPM---STQSASHAP--------------PHPVSILS--GASSSSPMSGE- 1103
            ..:..::    :||:.:   ||:|.|..|              |.|:...|  |.|...|:.|.
Zfish   596 GVNVSEKGTVGTLNSSVQFRSTESLSSVPRPLADIGMPVRLRYPPPLYWDSPRGLSFEDPVKGRI 660

  Fly  1104 -PAKKKGVRFEGIPDTL-PRSRSYSGNGAGTSGGGERERDRDKDKEGGGRHGHGHSSRR---RRR 1163
             .|.......:|....: ||.|...   |..|...:|:|.|        .|...|.|::   |.|
Zfish   661 GLAGSMSCMQDGNAQAMTPRPRRAQ---AQNSPRQQRQRQR--------HHRKNHKSQKYQYRSR 714

  Fly  1164 RKSSSSSSH----HRSGSG---HRSHSTTRADTYAPAQP-LSSSYQGP----------PSVLQAA 1210
            |..|.::.|    .:|..|   ||.|:    |...|:.. ||.:..|.          |.....:
Zfish   715 RSRSDNALHLATEDQSFPGDPIHRFHN----DFERPSSSRLSHNLFGANYGYRQQFFRPCPRTTS 775

  Fly  1211 NLVHESPSRQQREREREREREESEESD-VCSTCSSSSSSSED--YMMMYQLPQRRHYGGVRVSYV 1272
            :|..:.|...|..:...|..|..|:.| .||||||||.:|:|  |:....:|:     .|::.|.
Zfish   776 DLTLQDPGGPQIGQYMGRYGEAVEDEDQFCSTCSSSSEASDDDAYLPGEGIPR-----PVQLRYF 835

  Fly  1273 PNDALAYDRKRKPSELGGD---------KDKNCIIS 1299
            .|:.|.:  :..|:.:||.         |.||||||
Zfish   836 DNEELRH--RYSPTLVGGHTQLHTRKRRKSKNCIIS 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	68/94 (72%)
		LIM1_Prickle	624..682	CDD:188799	34/57 (60%)
		LIM2_Prickle	687..742	CDD:188802	41/54 (76%)
		LIM3_Prickle	747..805	CDD:188804	39/57 (68%)
prickle2a	NP_001071251.2	PET_Prickle	22..118	CDD:193602	68/95 (72%)
		LIM1_Prickle	126..184	CDD:188799	34/57 (60%)
		LIM2_Prickle	189..244	CDD:188802	41/54 (76%)
		LIM3_Prickle	249..307	CDD:188804	39/57 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586840
Domainoid	1	1.000	151	1.000	Domainoid score	I4309
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	518	1.000	Inparanoid score	I1235
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	1	1.000	-	-		FOG0001066
OrthoInspector	1	1.000	-	-		mtm6410
orthoMCL	1	0.900	-	-		OOG6_105250
Panther	1	1.100	-	-	O	PTHR24211
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.760