Protein Alignment pk and ZNF185

DIOPT Version :10

• Sequence 1: NP_724538.1
• Gene: pk / 45343
• FlyBaseID: FBgn0003090
• Length: 1299
• Species: Drosophila melanogaster
• Sequence 2: XP_016885310.1
• Gene: ZNF185 / 7739
• HGNCID: 12976
• Length: 766
• Species: Homo sapiens
• Alignment Length: 716
• Identity: 153/716 - (21%)
• Similarity: 233/716 - (32%)
• Gaps: 225/716 - (31%)

  Fly   125 SSTPKGGAT-----TAGRPLFPHSSSPRRSKKLLRSL------RAHVRGEKLPKNDTTTANESSE 178
            :.|||..|:     .||.|. |.||..:.:.:..:.|      |:...|:...:.:......||:
Human   109 NGTPKSAASLVRTANAGPPR-PSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVVPFSSD 172

  Fly   179 VTQRNARVTVLDDPFLFGI---DADHLGDLVVRGKRYSTLDAT-ENMARFYAEQEATAQVLEIIE 239
            ..:|.:...       .|:   .|......|:...:.||...| |..|.|.|::      :|::|
Human   173 EQKRRSEAA-------SGVLRRTAPREHSYVLSAAKKSTGSPTQETQAPFIAKR------VEVVE 224

  Fly   240 QEEESPEQEAPKPALP-----------PKQKQQRPV-----PPLPPPPANRVTQDQGTQPAAPQV 288
            ::..|.:.:.| |||.           .:.|..|.:     |.:|.|..::....:|.:....|:
Human   225 EDGPSEKSQDP-PALARSTPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQI 288

  Fly   289 PLQP-----LTAGDLQFLNLS--LRQRSLPRSMKPFKD-AHDISFTFNELD-------------- 331
             |.|     |.|.|::.:..|  .:.:..|.|.:..:| |.:.:|.....|
Human   289 -LTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVG 352

  Fly   332 ---TSAEPEVATGAAQQESNEPISRTPLTQISYLQKIPTLPRHFSPSGQGLATPPALGSGGMGLP 393
               |.:.||   |.|..:......|. ....|:...:.....|.:.|......|.|:.|
Human   353 SGATGSRPE---GLAAVDIGSERGRL-CAAASFASFLEDQDGHSANSQSCKPRPAAISS------ 407

  Fly   394 SSSSASAL--------YAAQAAAGILPTSPLPLQRHQQY---LPPHHQQHPGAGMGPGPGSGAAA 447
            |::|.||:        .|||..|...|...|.....:..   :....|:.|||   |..|.|..|
Human   408 SATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEAWQERPGA---PRGGQGDPA 469

  Fly   448 GP---PLGP-----QYSP----------GCSA----NPKYSNAQLPPPPHHHHQLSPALSTPSPP 490
            .|   |..|     |.||          .|.:    .|..|..::||.|         ...|...
Human   470 VPAQQPADPSTPERQSSPSGSEQLVRRESCGSRRVPQPDSSPKKIPPLP---------CGGPGQG 525

  Fly   491 SLLHHPAGG-------TSSASAHAPFLGGPHMDMQRQSHSDDDSGCALEEYTWVPPGLRPDQVRL 548
            |:....|||       |..||....|.|   .|:..:      .|.|.::....|.|.:.|.. :
Human   526 SIRRDKAGGHIGDCLLTPGASVLTDFEG---KDVATK------VGEAWQDRPGAPRGGQGDPA-V 580

  Fly   549 YFSQIPDDKVP-YVNSP--GEQY--------RVRQLLHQLPPHDNEVRYCHSLTDEE-------- 594
            ...|..|...| ..|||  .||:        |||.      |....|....:.|.|:
Human   581 PTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRS------PSSCMVTVTVTATSEQPHIYIPAP 639

  Fly   595 RKELRLFSTQRKRDALGRG--------NVRQLMSARPCDGCDDLIS------------------- 632
            ..||...||.       :|        |..::.|.:|.......:|
Human   640 ASELDSSSTT-------KGILFVKEYVNASEVSSGKPVSARYSNVSSIEDSFAMEKKPPCGSTPY 697

  Fly   633 ----TGDIAVFATR------------LGPNASWHPACFACSVCREL---LVDLIYFHRDGRMYCG 678
                ||.|..:..|            ||  ...|..||.|.:|.:.   |:|.|:.||| .::||
Human   698 SERTTGGICTYCNREIRDCPKITLEHLG--ICCHEYCFKCGICSKPMGDLLDQIFIHRD-TIHCG 759

  Fly   679 R 679
            :
Human   760 K 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	26/121 (21%)
		LIM1_Prickle	624..682	CDD:188799	20/94 (21%)
		LIM2_Prickle	687..742	CDD:188802
		LIM3_Prickle	747..805	CDD:188804
ZNF185	XP_016885310.1	LIM	705..761	CDD:214528	17/59 (29%)