Protein Alignment pk and TGFB1I1

DIOPT Version :9

• Sequence 1: NP_724538.1
• Gene: pk / 45343
• FlyBaseID: FBgn0003090
• Length: 1299
• Species: Drosophila melanogaster
• Sequence 2: NP_001035919.1
• Gene: TGFB1I1 / 7041
• HGNCID: 11767
• Length: 461
• Species: Homo sapiens
• Alignment Length: 617
• Identity: 132/617 - (21%)
• Similarity: 190/617 - (30%)
• Gaps: 231/617 - (37%)

  Fly   235 LEIIEQEEESPEQEAPKPALPPKQKQQRPVPPLPPPPA-----------------------NRVT 276
            |:.:..:.|:.....|:...|    ::||..||.|||:                       :.|.
Human     4 LDALLSDLETTTSHMPRSGAP----KERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLYSTVC 64

  Fly   277 QDQGTQPAAPQVPLQPLTAGDLQFLNLSLRQRSLPRSMKPFKDAHDISFTFNELDTSAEPEVATG 341
            :.:..:||||..|....::|   .|...|.:  |.|.::.. :|...:.|...:......:||:|
Human    65 KPRSPKPAAPAAPPFSSSSG---VLGTGLCE--LDRLLQEL-NATQFNITDEIMSQFPSSKVASG 123

  Fly   342 AAQQESNEPISRTPLTQISYLQKIPTLPRHFSPSGQGLATPPALGSGGMGLPSSSSASALYAAQA 406
            ..:::.:|.            :|.|:||...||                |||.:|:.||......
Human   124 EQKEDQSED------------KKRPSLPSSPSP----------------GLPKASATSATLELDR 160

  Fly   407 AAGILPTSPLPLQRHQQYLPPHHQQHPGAGMGPGPGSGAAAGPPLGPQYSPGCSANPKYSNAQLP 471
            ....|  |...:|.|   ||                   |:||...|..|   |.|.
Human   161 LMASL--SDFRVQNH---LP-------------------ASGPTQPPVVS---STNE-------- 190

  Fly   472 PPPHHHHQLSPALSTPSPPSLLHHPAGGTSSASAHAPFLGGPHMDMQRQSHSDDDSGCALEEYTW 536
                         .:||||    .|.|..|..:    .||....|:.|:.
Human   191 -------------GSPSPP----EPTGKGSLDT----MLGLLQSDLSRRG--------------- 219

  Fly   537 VPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQYRVRQLLHQLPPHDNEVRYCHSLTDEERKELRLF 601
                                 ||
Human   220 ---------------------VP------------------------------------------ 221

  Fly   602 STQRKRDALGRGNVRQLMSARPCDGCDDLISTGDIAVFATRLGPNASWHPACFACSVCRELLVDL 666
             ||.|               ..|..|:..|: |.:   .|.||  .:|||..|.|..|...|...
Human   222 -TQAK---------------GLCGSCNKPIA-GQV---VTALG--RAWHPEHFVCGGCSTALGGS 264

  Fly   667 IYFHRDGRMYCGRHHAETLKPRCSACDEIILADECTEAEGRAWHMNHFACHECDKQLGGQRYIMR 731
            .:|.:||..:|...:.|...|||..|::.| ..:...|.|..||..||.|..|.:..|.:.:..|
Human   265 SFFEKDGAPFCPECYFERFSPRCGFCNQPI-RHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHER 328

  Fly   732 EGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQHWHATDECFSCNTCRCSLLGRAFLPRRG 796
            ||:|||...|..:||..|..|...| :| ..:|.....||  .:||.|..|.....|.:|....|
Human   329 EGRPYCRRDFLQLFAPRCQGCQGPI-LD-NYISALSALWH--PDCFVCRECFAPFSGGSFFEHEG 389

  Fly   797 AIYC---------SIACSKGEPPTPSDSSGTG 819
            ...|         |:..:.|.|.|....|..|
Human   390 RPLCENHFHARRGSLCATCGLPVTGRCVSALG 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	5/94 (5%)
		LIM1_Prickle	624..682	CDD:188799	18/57 (32%)
		LIM2_Prickle	687..742	CDD:188802	20/54 (37%)
		LIM3_Prickle	747..805	CDD:188804	16/66 (24%)
TGFB1I1	NP_001035919.1	Interaction with PTK2B/PYK2	1..240		73/427 (17%)
		Transcription activation. /evidence=ECO:0000250	1..200		58/285 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..87		18/89 (20%)
		LD motif 1	3..15		2/10 (20%)
		Interaction with PTK2/FAK1. /evidence=ECO:0000250	83..136		12/70 (17%)
		Paxillin	<86..>106	CDD:308898	5/22 (23%)
		LD motif 2	92..104		3/14 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..152		14/63 (22%)
		LD motif 3	157..168		2/12 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	172..205		17/82 (21%)
		LD motif 4	203..215		3/15 (20%)
		LIM1_Paxillin_like	228..280	CDD:259830	18/57 (32%)
		LIM2_Paxillin_like	287..338	CDD:188723	18/51 (35%)
		LIM3_Paxillin	346..398	CDD:188793	15/55 (27%)
		LIM4_Leupaxin	405..456	CDD:188796	5/17 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593918at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920