DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pk and pxnb

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	XP_021334029.1	Gene:	pxnb / 565130	ZFINID:	ZDB-GENE-130530-697	Length:	1197	Species:	Danio rerio

Alignment Length:	979	Identity:	201/979 - (20%)
Similarity:	292/979 - (29%)	Gaps:	359/979 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SGGPGGADAAAAPAAGQATVTATGNMEPAMVPRTANLLACKQWWRVCFLYGDQQKYYRQLYSKAA 78
            |.||...:......:|          ||..||..:|              |..:.|.|.....|:
Zfish   346 SPGPSSFELHIVEDSG----------EPGAVPLPSN--------------GVFKSYSRLSPPPAS 386

  Fly    79 AQRLADANQEPDNARDREYDTVDCDLIAGQLDAVEDADDGIDLGDHSSTPKGGATTAGRPLFPHS 143
            :.|.:.|   ||...|...| |...|::.:::::......|.:   :|.|:|...:..|     .
Zfish   387 SPRFSPA---PDLGLDSAID-VSASLLSSEVESLVVLSQTIPM---TSAPRGQYLSPVR-----E 439

  Fly   144 SSPRRSKKLLRS-LRAHVRGEKLPKNDTTTANESSEVTQRNARVTVLDDPFLFGIDADHLGDLVV 207
            .||  |.||:.| |.::....|.|     :...|..:::.|.||:.|..|...        ||.:
Zfish   440 GSP--SAKLMNSGLNSYSPNTKSP-----SPRSSPAISRVNERVSPLMTPASI--------DLYL 489

  Fly   208 RGKRYSTLDATENMARFYAEQEATAQVLEIIEQEEESPEQEAPKPALP----------PKQKQQ- 261
            .......|....::.|......:.:..|.:       |:..:|.|.:|          |..||:
Zfish   490 SRPETKPLSPVPSLPRSPLPAVSESSFLSL-------PKALSPPPIIPTSPTLGVSKSPSPKQES 547

  Fly   262 ---RPV----PPLPPP--------------------PANRV-----TQDQGTQPAAPQVPLQPLT 294
               .||    |.|.||                    |.|..     ...|.|..|.|::..:.:.
Zfish   548 AYLEPVVSLKPHLEPPTYEPSLDDALDKLLAMSFSRPENETHITASASSQLTSEAQPEIYEESIV 612

  Fly   295 AGDLQFLNLSLRQRSLPRSMKPFKDAHDISFTFNELDTSAEPEVATGAAQQESN----------- 348
            |.|              ||     |.|.        ||..|.|:..|..:.:|:
Zfish   613 AAD--------------RS-----DIHP--------DTHTESEMGDGLLEDQSDCRSDLDWADME 650

  Fly   349 -------EPISRTPLTQISYLQKIPTLPRHFSPSGQGLATPPALGSGGMGLP------------- 393
                   ...|.||:|:.|::..      ..:||     :.|......|.||
Zfish   651 LKMAYEGPDGSMTPMTEASWMDD------SLTPS-----SCPGTPDAQMDLPMLHMAGTMDRISA 704

  Fly   394 -------------------------------------SSSSASALYAAQAAAGIL---------- 411
                                                 |:|....:...|...||.
Zfish   705 SGHIKSVIRRTKEIQNVHPMYRDGLIRRKMGPLIFHKSNSQDRLIEELQGKLGIARKEKAKKQQP 769

  Fly   412 -------------------------------PTSPLPLQRHQQYLPPHHQQHPGAGMGPGPGSGA 445
                                           |.||||  :.:..|||   |.|..   |.|
Zfish   770 DDWLTEGVIVMSNPKRSREDHNRDVDKIIIPPESPLP--QRKMILPP---QSPPM---PRP---- 822

  Fly   446 AAGPPLGPQYSPGCSANPKYSNAQLPPPPHHHHQLSPALSTPSP--------------------- 489
               ||  |...|.|....|.:.|.|||||.......|...||.|
Zfish   823 ---PP--PAEEPKCPPVVKLAPAPLPPPPPPAPSPPPREPTPPPQPTLPPVPPKPPTPEPVVVPA 882

  Fly   490 PSLLHHPAGGTSSASAHAPFLGGPHMDMQRQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIP 554
            ||....||...|.....||.  .|...:.       ..||..|.....||          ...:.
Zfish   883 PSPKPKPAPPPSPIPPPAPV--SPPKVLA-------SVGCQTEYDPLFPP----------LQIMA 928

  Fly   555 DDKVPYVNSPGEQYRVRQLLHQLPPHDNEVRYCHSLTDEERKELRLFSTQRKRDALGRGNVRQLM 619
            ..|.|:    |:..::..:|..|                 :.:|.....|    .:.:|
Zfish   929 QGKGPH----GQANKLDNMLGSL-----------------QSDLHKLGVQ----TVAKG------ 962

  Fly   620 SARPCDGCDDLISTGDIAVFATRLGPNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAET 684
               .|..|...|    :....|.:|  .:|||..|.|:.|:|.:....:|.|:|:.||.|.:...
Zfish   963 ---VCGACSKPI----VGQVVTAMG--RTWHPEHFVCTHCQEEIGSRNFFEREGQPYCERDYHHL 1018

  Fly   685 LKPRCSACDEIILADECTEAEGRAWHMNHFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYC 749
            ..|||..|:..|| |:...|..|.||..||.|.:|....|.:.:..::||.||...:..:||..|
Zfish  1019 FSPRCYYCNGPIL-DKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDLFAPKC 1082

  Fly   750 DYCGEAIGVDQGQMSHDGQHWHATDECFSCNTCRCSLLGRAFLPRRGAIYCSI--------ACSK 806
            ..|..||  .:..:|.....||  .|||.|..|....:..:|....|..||.:        .||.
Zfish  1083 GGCARAI--LENYISALSSLWH--PECFVCRECFTPFVNGSFFEHDGQPYCEVHYHARRGSLCSG 1143

  Fly   807 GEPP 810
            .:.|
Zfish  1144 CQKP 1147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	13/94 (14%)
		LIM1_Prickle	624..682	CDD:188799	18/57 (32%)
		LIM2_Prickle	687..742	CDD:188802	20/54 (37%)
		LIM3_Prickle	747..805	CDD:188804	16/65 (25%)
pxnb	XP_021334029.1	Paxillin	96..272	CDD:308898
		Atrophin-1	<178..684	CDD:331285	85/433 (20%)
		LIM1_Paxillin_like	964..1016	CDD:259830	18/57 (32%)
		LIM2_Paxillin_like	1023..1074	CDD:188723	18/51 (35%)
		LIM3_Paxillin_like	1082..1134	CDD:188724	16/55 (29%)
		LIM4_Paxillin	1141..1192	CDD:188795	3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593918at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920