DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pk and lpxn

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	XP_689239.4	Gene:	lpxn / 560743	ZFINID:	ZDB-GENE-081105-159	Length:	405	Species:	Danio rerio

Alignment Length:	350	Identity:	92/350 - (26%)
Similarity:	130/350 - (37%)	Gaps:	75/350 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   462 NPKYSNAQLPPPPHHHHQLSPALSTPSPPSLLHHPAGGTSSASAHAPFLGGPHMDMQ----RQSH 522
            || ||   :|..|.....:||..:|....||::...|.....|..||....|.:..:    :.:.
Zfish    56 NP-YS---VPTAPVEASLMSPRTATRELDSLMNDLLGLDLEVSEPAPSSNPPPLARKSIKAKTTE 116

  Fly   523 SDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQY-----RVRQLLHQLPPHDN 582
            ...:||...:|                     .|:.|......|::     .:..||..|.
Zfish   117 ETGESGSGRQE---------------------GDRKPQHPPLSEKFSKGVDAIDDLLGSLS---- 156

  Fly   583 EVRYCHSLTDEERKELRLFSTQRKRDALGRGNVRQLMSARPCDGCDDLISTGDIAVFATRLGPNA 647
                    :|.|:..:|         ...:|:         |..|...|:    ....|.||  .
Zfish   157 --------SDMEKMGVR---------TAAKGH---------CASCGKCIA----GKMITALG--Q 189

  Fly   648 SWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAETLKPRCSACDEIILADECTEAEGRAWHMN 712
            .|||..|.||.|||.|....:|.|||:.||.:.:.:...|||:.|...|..:..| |..:.||..
Zfish   190 VWHPEHFVCSACREELGTCGFFERDGKPYCEKDYQKLFSPRCAYCKGPITQNILT-AMDQTWHPE 253

  Fly   713 HFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQHWHATDECF 777
            ||.|..|....|.:.|:.|:|||||...|..:||..|..|||.  |.:..:|.....||  .:||
Zfish   254 HFFCCHCGDLFGPEGYLERDGKPYCSRDFYCLFAPKCSGCGEP--VKENYLSAANGTWH--PDCF 314

  Fly   778 SCNTCRCSLLGRAFLPRRGAIYCSI 802
            .|:.|........||...|...||:
Zfish   315 VCSDCLKPFTDGCFLELNGRPLCSL 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	13/99 (13%)
		LIM1_Prickle	624..682	CDD:188799	22/57 (39%)
		LIM2_Prickle	687..742	CDD:188802	21/54 (39%)
		LIM3_Prickle	747..805	CDD:188804	17/55 (31%)
lpxn	XP_689239.4	LIM1_Paxillin_like	172..224	CDD:259830	22/57 (39%)
		LIM2_Leupaxin	231..282	CDD:188792	19/51 (37%)
		LIM3_Leupaxin	290..342	CDD:188794	17/53 (32%)
		LIM4_Leupaxin	349..400	CDD:188796
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593918at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920