DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pk and prickle1

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	XP_012814522.1	Gene:	prickle1 / 549693	XenbaseID:	XB-GENE-486941	Length:	871	Species:	Xenopus tropicalis

Alignment Length:	947	Identity:	325/947 - (34%)
Similarity:	447/947 - (47%)	Gaps:	219/947 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   481 SPALSTPSPPSL---------LHHPAGGTSSASAHAPFLGGPHMDMQRQSHSDDDSGCALEEYTW 536
            ||..|..||.::         ::.|.......|.|.       ...||.|.||||||||:|||||
Frog    16 SPWKSVSSPRAIDELERPITTVYMPLEMDQKISKHT-------FGCQRSSTSDDDSGCAMEEYTW 73

  Fly   537 VPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQYRVRQLLHQLPPHDNEVRYCHSLTDEERKELRLF 601
            |||||||:||:|||:.:|:.|||||||.||:.|::|||:||||||||||||.||::||:|||::|
Frog    74 VPPGLRPEQVQLYFACLPEAKVPYVNSVGEKCRIKQLLYQLPPHDNEVRYCQSLSEEEKKELQMF 138

  Fly   602 STQRKRDALGRGNVRQLMSA---RPCDGCDDLISTGDIAVFATRLGPNASWHPACFACSVCRELL 663
            |.|||::||||||::.|..|   ..|:.|.:.|:.|:||:|.:|.||...|||:||.||.|.|||
Frog   139 SAQRKKEALGRGNIKMLSRAVMHAMCEKCGEKINGGEIAIFVSRAGPGVCWHPSCFVCSTCNELL 203

  Fly   664 VDLIYFHRDGRMYCGRHHAETLKPRCSACDEIILADECTEAEGRAWHMNHFACHECDKQLGGQRY 728
            ||||||::||:::|||||||.||||||||||||.||||||||||.||||||:|:||:..||||||
Frog   204 VDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMNHFSCYECETVLGGQRY 268

  Fly   729 IMREGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQHWHATDECFSCNTCRCSLLGRAFLP 793
            ||::|:|:|..||::.:||||:.|||.||||..||::||||||||:.||||..|:.||||..|||
Frog   269 IMKDGRPFCCGCFESHYAEYCESCGEHIGVDHAQMTYDGQHWHATETCFSCAQCKVSLLGCPFLP 333

  Fly   794 RRGAIYCSIACSKGEPPTPSDSSGTGMYTTPTPPTQRVRPHPQAPLPARIPSSHASS-------- 850
            ::|.||||.|||.||....||||.:...:..:..::|         ..|:..|..|:
Frog   334 KKGRIYCSKACSLGEDVHASDSSDSAFQSARSRESRR---------SVRMGKSSRSADQCRQSLL 389

  Fly   851 -SPPMS---PQQQQQHQATFNQAMYQMQSQQMEAAGGLVDQSKSYAASDSDAGVVKD-------- 903
             ||.::   |........|.::.|..:..            |:..|..|:|....:|
Frog   390 LSPALNYKFPGMSGNADDTLSRKMDDLSI------------SRQGAGFDNDFWKARDEQETPEDH 442

  Fly   904 ---LEHGGHMGGGDLTDFSGGRASSTSQNLSPLNSPGDFQPHFLPKPMELQRDGVYNFNEMSSNL 965
               .||..:|                :|.|......|.||        :...|...|.:.||.|:
Frog   443 EEWAEHDDYM----------------TQLLLKFGEKGLFQ--------QAPEDNRSNEHWMSDNI 483

  Fly   966 ----------------------------------DAAWSAKPTNSYHLQRQLLENPHTAS----- 991
                                              |:|:.:.|..:...:.|.|:..|.||
Frog   484 KGKNDLQRNSRNQSLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRKLQELDMDHGASGYMHE 548

  Fly   992 -MPELAGKLVAPPAHMQHLSQLHAVSSHQFQQHEY---------------ADILHPPPPPPG--- 1037
             ||             .:...|..:|.:...|:|.               |.:.....|.|.
Frog   549 KMP-------------WYKRSLECLSDNLKPQNENICDSMDSLALSNITGASVDRENKPRPSLFS 600

  Fly  1038 --EIPELPTPNLSVAST--ALPPELMGSPTHSAGDRSLNTPMSTQS--ASHAPPHPVSILSGASS 1096
              ...:|.|.:....|.  .|...::...|.|.  :|||:.:..:.  ....|.|..::....|.
Frog   601 YQNFQDLNTRDCEKMSNMGTLNSSMLNRSTESL--KSLNSEICQEKPPPEEKPMHTSALRRSKSQ 663

  Fly  1097 SSPMSGEPAKKKGVRFEGIPDTLPRSRSYSGNGAGTSGG--------GERERDRDKDKEGGGRHG 1153
            :.|.         |:|.  .|.:..         |..|.        .||.|.|..:.|...:..
Frog   664 TRPQ---------VKFS--DDVIDN---------GDCGSIDIRQPPMSERSRRRVYNFEERSQRP 708

  Fly  1154 HGHSSRRRRRRKSSSSSSHH-----RSGSGHRSHSTTRADTYAPAQPLSSSYQGPPSVLQAANLV 1213
            |.|  |||:.|||.|.::.|     :.....|:.....|:.|.......|::: ..:.:|.|:|.
Frog   709 HHH--RRRKSRKSRSENALHLATESKPSGRERNPRFYTAEDYEKLFHNRSAHE-VQAYIQNADLF 770

  Fly  1214 HESPSRQQREREREREREE------SEESDVCSTCSSSSSSSED--YMM----MYQLPQRRHYGG 1266
            .:.|:.........:..::      .:|...|||||||||.||:  |.:    ...||||..|..
Frog   771 GQYPNAASNFGLPSQVVDKFLGLYGEDEDSWCSTCSSSSSDSEEEGYFLGQPIPKPLPQRYQYFS 835

  Fly  1267 VRVSYVPNDALA----YDRKRKPSELGGDKDKNCIIS 1299
            ..:. .|.:||:    ..|..|..:..|.|.||||||
Frog   836 DDLC-SPTNALSSSQFSQRTTKSKKKKGHKGKNCIIS 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	69/94 (73%)
		LIM1_Prickle	624..682	CDD:188799	33/57 (58%)
		LIM2_Prickle	687..742	CDD:188802	41/54 (76%)
		LIM3_Prickle	747..805	CDD:188804	38/57 (67%)
prickle1	XP_012814522.1	PET_Prickle	60..156	CDD:193602	69/95 (73%)
		LIM1_Prickle	164..222	CDD:188799	33/57 (58%)
		LIM2_Prickle	227..282	CDD:188802	41/54 (76%)
		LIM3_Prickle	287..345	CDD:188804	38/57 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I4502
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	511	1.000	Inparanoid score	I1284
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	1	1.000	-	-		FOG0001066
OrthoInspector	1	1.000	-	-		mtm14087
Panther	1	1.100	-	-	O	PTHR24211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3342
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.100