DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pk and FBLIM1

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_001019386.1	Gene:	FBLIM1 / 54751	HGNCID:	24686	Length:	374	Species:	Homo sapiens

Alignment Length:	433	Identity:	102/433 - (23%)
Similarity:	154/433 - (35%)	Gaps:	113/433 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   419 QRHQQYLPPHHQQHPGAGMG--PGPGS---GAAAGPPLGPQ--YSPGCSANPKYSNAQ------- 469
            :|.:.:..|...:.|.||:.  |.|.:   .|||..|..|.  ::.||...|...:.:
Human    38 RRGRPWEAPAPMKTPEAGLAGRPSPWTTPGRAAATVPAAPMQLFNGGCPPPPPVLDGEDVLPDLD 102

  Fly   470 -LPPPPHHHHQLSPALSTPSPPSLLHHPAGGTSSASAHAPFLGGPHMDMQRQSHSDDDSGCALEE 533
             |||||            |.||.||      .|...|.||.......|              ||:
Human   103 LLPPPP------------PPPPVLL------PSEEEAPAPMGASLIAD--------------LEQ 135

  Fly   534 YTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQYRVRQLLHQLPPHDNEVRYCHSLTDEERKEL 598
            ....||...|        |.|.:. |.| .||.   :|.:..:|||...|
Human   136 LHLSPPPPPP--------QAPAEG-PSV-QPGP---LRPMEEELPPPPAE--------------- 172

  Fly   599 RLFSTQRKRDALGRGNVRQLMSARPCDGCDDLISTGDIAVFATRLGPNASWHPACFACSVCRELL 663
                           .|.:..|...|..|...:|..::||.|.:    ..:|..||.|..||..|
Human   173 ---------------PVEKGASTDICAFCHKTVSPRELAVEAMK----RQYHAQCFTCRTCRRQL 218

  Fly   664 VDLIYFHRDGRMYCGRHHAETLKPRCSACDEIILADECTEAEGRAWHMNHFACHECDKQLGGQRY 728
            ....::.:|||..|...:.:||: ||..|.|:: .|....|.|:|:|.:.|.|..|.:.:|.:.:
Human   219 AGQSFYQKDGRPLCEPCYQDTLE-RCGKCGEVV-RDHIIRALGQAFHPSCFTCVTCARCIGDESF 281

  Fly   729 IM-REGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQHWHATDECFSCNTCRCSLLGRAFL 792
            .: .:.:.|||..|.......|...|...|.|..::    :....:..|::..:|........:.
Human   282 ALGSQNEVYCLDDFYRYEKGLCTGWGAGTGRDPSRV----KELSLSPGCWARVSCLLVYYKEYYR 342

  Fly   793 PRRGAIYCSIACSKGEPPTPSDSSGTGMYTTPTPPTQRVRPHP 835
            ...||:  :.||:      ||...|.|.:.|.:..    |.||
Human   343 AGLGAV--AHACN------PSTLGGRGGWITRSGD----RDHP 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	17/94 (18%)
		LIM1_Prickle	624..682	CDD:188799	17/57 (30%)
		LIM2_Prickle	687..742	CDD:188802	16/55 (29%)
		LIM3_Prickle	747..805	CDD:188804	9/57 (16%)
FBLIM1	NP_001019386.1	Filamin-binding	1..70		7/31 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..119		25/95 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	135..176		15/83 (18%)
		LIM	183..236	CDD:259829	17/56 (30%)
		LIM2_FBLP-1	243..295	CDD:188758	15/52 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810