DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pk and Prickle3

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_001277553.1	Gene:	Prickle3 / 54630	MGIID:	1859635	Length:	624	Species:	Mus musculus

Alignment Length:	801	Identity:	274/801 - (34%)
Similarity:	344/801 - (42%)	Gaps:	268/801 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   516 DMQRQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQYRVRQLLHQLPPH 580
            |.||.|.||||||||.|||.||||||:|:||..:||.:|:|||||||||||:||::|||||||||
Mouse    75 DFQRHSISDDDSGCASEEYAWVPPGLKPEQVYQFFSCLPEDKVPYVNSPGEKYRIKQLLHQLPPH 139

  Fly   581 DNEVRYCHSLTDEERKELRLFSTQRKRDALGRGNVR---QLMSARPCDGCDDLISTGDIAVFATR 642
            |:|.:||.:|.:||:||||.||.||||:.|||..||   ..::...|:.|...|..|||||||:|
Mouse   140 DSEAQYCTALEEEEKKELRAFSQQRKRENLGRATVRIFPVTITGAICEECGKQIGGGDIAVFASR 204

  Fly   643 LGPNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAETLKPRCSACDEIILADECTEAEGR 707
            .|..|.|||.||.|:.|:|||||||||:..|::||||||||.|:|||.||||||.:.||||||||
Mouse   205 AGLGACWHPQCFVCTTCQELLVDLIYFYHAGKVYCGRHHAECLRPRCQACDEIIFSPECTEAEGR 269

  Fly   708 AWHMNHFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQHWHA 772
            .|||.||.|.||:..||||||:||:.:|:|..|::|..|||||.|||.||:|||||:::||||||
Mouse   270 HWHMGHFCCFECEASLGGQRYVMRQSRPHCCACYEARHAEYCDGCGEHIGLDQGQMAYEGQHWHA 334

  Fly   773 TDECFSCNTCRCSLLGRAFLPRRGAIYCSIACSKGEPPTPSDSSGTGMYTTPTPPTQRVRPHPQA 837
            :|.||.|:.|...||||.||||||.|:||.|||.|...|                         |
Mouse   335 SDRCFCCSRCSRPLLGRPFLPRRGLIFCSRACSLGSETT-------------------------A 374

  Fly   838 PLPARIPSSHASSSPPMSPQQQQQHQATFNQAMYQMQSQQMEAAGGLVDQSKSYAASDSDAGVVK 902
            |.|.|...|..:.:.|                              |...:.|::|::
Mouse   375 PGPGRRSWSAGTVTTP------------------------------LTTSTASFSATE------- 402

  Fly   903 DLEHGGHMGGGDLTDFSGGRASSTSQNLSPLNSPGDFQPHFLPKPMELQRDGVYNFNEMSSNLDA 967
                              |.:.:.|:.......|
Mouse   403 ------------------GTSETASKGTCTKAEP------------------------------- 418

  Fly   968 AWSAKPTNSYHLQRQLLENPHTASMPELAGKLVAPPAHMQHLSQLHAVSSHQFQQHEYADILHPP 1032
              :|.|....|..|..   ||..|||||.                                |...
Mouse   419 --AAGPEEPSHFLRGA---PHRHSMPELG--------------------------------LRSA 446

  Fly  1033 PPPPGEIPELPTPNLSVASTALPPELMGSPTHSAGDRSLNTPMSTQSASHAPPHPVSILSGASSS 1097
            |.||.|.|..|.|:               |..:|..|     .||...|...|    ::|.....
Mouse   447 PEPPTESPGHPAPH---------------PDDNAFGR-----QSTPRVSFRDP----LVSEGGPR 487

  Fly  1098 SPMSGEPAKKKGVRFEGIPDTLPRSRSYSGNGAGTSGGGERERDRDKDKEGGGRHGHGHSSRRRR 1162
            ..:|..||                               :|.|.|.........|.|.|..|||:
Mouse   488 RTLSAPPA-------------------------------QRRRPRSPPPRTPSCHHHHHHRRRRQ 521

  Fly  1163 RRKSSSSSSHHRSGSGHRSHSTTRADTYAPAQPLSSSYQGPPSVLQAANLVHESPSRQQRERERE 1227
            |.:...|..||.....|..|   |.|..:.:.  |.|....||          |||
Mouse   522 RHRRRGSHHHHHHPGRHGHH---RCDLGSGSD--SGSCSSSPS----------SPS--------- 562

  Fly  1228 REREESEESD-------------VCSTCSSSSSSSEDYMMMYQ-LPQRRHYGGVRVSYVPNDALA 1278
               .||.|.|             :|...::..:|:|.:....| |.|..|      ..:|...
Mouse   563 ---SESSEDDGFFLGERIPLPPHLCRPRTTQDTSTETFNSPAQPLVQESH------PVMPRQT-- 616

  Fly  1279 YDRKRKPSELGGDKDKNCIIS 1299
                         :|||||::
Mouse   617 -------------RDKNCIVA 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	67/97 (69%)
		LIM1_Prickle	624..682	CDD:188799	35/57 (61%)
		LIM2_Prickle	687..742	CDD:188802	36/54 (67%)
		LIM3_Prickle	747..805	CDD:188804	39/57 (68%)
Prickle3	NP_001277553.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		PET_Prickle	82..178	CDD:193602	67/95 (71%)
		LIM1_Prickle	186..244	CDD:188799	35/57 (61%)
		LIM2_Prickle	249..304	CDD:188802	36/54 (67%)
		LIM3_Prickle	309..367	CDD:188804	39/57 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..617		79/496 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842420
Domainoid	1	1.000	104	1.000	Domainoid score	I6681
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3648
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	1	1.000	-	-		FOG0001066
OrthoInspector	1	1.000	-	-		mtm11117
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24211
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.900