DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pk and esn

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_001260760.1	Gene:	esn / 53557	FlyBaseID:	FBgn0263934	Length:	1134	Species:	Drosophila melanogaster

Alignment Length:	1377	Identity:	486/1377 - (35%)
Similarity:	626/1377 - (45%)	Gaps:	370/1377 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LLACKQWWRVCFLY---GDQQKYYRQLYSKAAAQRLADANQEPDNARDREYDTVDCDLIAGQLDA 111
            :|:.|:||::....   .||.:.||.:.:      |::.:....|......|:......:|....
  Fly     1 MLSKKRWWKIRLPQVGKQDQSRNYRDIVN------LSECSSVLANTATTISDSSTTTASSGSPTR 59

  Fly   112 VEDADDGIDLGDHSSTPKGGATTAGRPLFPHS-SSPRRSKKLLRS-----------LRAHVRGEK 164
            ....|         |..|.....||: |||.: .|.|||::...|           |...|:..|
  Fly    60 HRSCD---------SLSKSSQAEAGK-LFPRNMPSIRRSRRRAVSAERERLASRERLEEQVQPPK 114

  Fly   165 LPKNDTTTANESSEVT-----QRNARVTVLDDPFLFGIDADHLGDLVVRGKRYSTLDATENMARF 224
            :|:......:..|.||     :::::.|.          :.|.|:...:       ...::..|.
  Fly   115 MPQIGAGQQSRLSTVTKLTPRKQSSKSTC----------SKHRGNAPAK-------CIIKSAVRT 162

  Fly   225 YAEQEATAQVLEIIEQEEESPEQEAPKPALPPKQKQ-----QRPVP------------------- 265
            ..:.:||...|...|...|.| .|:|.|.|.....|     ||.:.
  Fly   163 KTKPKATTITLAPYEIALELP-NESPAPTLAMAVAQSSGCVQRKLSSEDQFHSSGISCNGETDDD 226

  Fly   266 --------PLPPPPANRVTQDQGTQPAAPQVPLQPLTAGDLQFLNLSLRQRSL---PRSMKPFKD 319
                    .|.|   :::.:.||.         |.|...||:.||....:.::   |:..:...:
  Fly   227 VEVAMLTGSLTP---SQIARIQGQ---------QILRYDDLRNLNRCRNRNAVWLNPKDTEQLLE 279

  Fly   320 ----------------AHDISFT--------FNELDTSAEPEVATGAAQQESNEPISR---TPLT 357
                            |.||..:        |:.......|..||.....:.::.|.:   ||..
  Fly   280 VDKSRRKANCYFNQAIADDIQLSDIEEQLARFDGHSKRPPPPAATAPKITQPSQVIEKFKPTPAP 344

  Fly   358 QIS-YLQKIPTLPRHFSPSGQGLATPP-----ALGSGGMGLPSSSSASALYAAQAAAGILPTSPL 416
            :.| .:|:.|...:|..|......|..     .:.:||.||..:|.:..           |.|.:
  Fly   345 RSSGNMQQAPQQQQHPHPPSSSYYTQTESELLQIEAGGTGLTFASHSQR-----------PESAI 398

  Fly   417 PLQRHQQYLPPHHQQHPGAGMGPGPGSGAAAGPPLGPQYSPGCSANPKYSNAQLPPPPHHHHQLS 481
                 .|.....|...|.|. ..|.|..|.:|...|...|.|...:| .......||.|     .
  Fly   399 -----SQVASTAHLDVPSAA-SSGSGGSAVSGGSGGAPESAGRFVSP-LQRRHCQPPSH-----L 451

  Fly   482 PALSTPSPPSLLHHPAGGTSSASAHAPFLGGPH--MDMQRQSHSDDDSGCALEEYTWVPPGLRPD 544
            |..|..||   |...:..:::|.|...|....|  :|.||.|.||||||||||||||||||||||
  Fly   452 PLNSVASP---LRTASYKSAAAVAGHGFHHSHHQQLDFQRNSQSDDDSGCALEEYTWVPPGLRPD 513

  Fly   545 QVRLYFSQIPDDKVPYVNSPGEQYRVRQLLHQLPPHDNEVRYCHSLTDEERKELRLFSTQRKRDA 609
            ||||||||:|||||||||||||:|||:||||||||.||||||||||:||||||||:||.||||:|
  Fly   514 QVRLYFSQLPDDKVPYVNSPGEKYRVKQLLHQLPPQDNEVRYCHSLSDEERKELRIFSAQRKREA 578

  Fly   610 LGRGNVRQLMSARPCDGCDDLISTGDIAVFATRLGPNASWHPACFACSVCRELLVDLIYFHRDGR 674
            ||||.||.|...|||.||::.:|.|||.|||.|||....|||.||.||||:|||||||||.|||.
  Fly   579 LGRGAVRLLSDERPCKGCEEPLSGGDIVVFAQRLGAQLCWHPGCFVCSVCKELLVDLIYFQRDGN 643

  Fly   675 MYCGRHHAETLKPRCSACDEIILADECTEAEGRAWHMNHFACHECDKQLGGQRYIMREGKPYCLH 739
            :|||||||||.|||||||||||.:|||||||||.|||.||||.||:.|||||||||||||||||.
  Fly   644 LYCGRHHAETQKPRCSACDEIIFSDECTEAEGRTWHMKHFACQECEHQLGGQRYIMREGKPYCLA 708

  Fly   740 CFDAMFAEYCDYCGEAIGVDQGQMSHDGQHWHATDECFSCNTCRCSLLGRAFLPRRGAIYCSIAC 804
            |||.|||||||||||.|||||||||||||||||||:||||.|||||||||.||||||.|||||||
  Fly   709 CFDTMFAEYCDYCGEVIGVDQGQMSHDGQHWHATDQCFSCCTCRCSLLGRPFLPRRGTIYCSIAC 773

  Fly   805 SKGEPPTPSD-SSGTGMYTTPTPPTQRVRPHPQAPLPARIPSS-HASSSPPMSPQQQQQH---QA 864
            |||||||||| |||           .::||..:|...::|..| .........|.::..|   :|
  Fly   774 SKGEPPTPSDTSSG-----------PQLRPTHRASTSSQIAKSPRRGGERERDPGRKAHHGHPKA 827

  Fly   865 T--FNQAMYQMQSQQMEAAGGLVDQSKSYAASDSDAGVVKDLEHGGHMGGGDLTDFSGGRASSTS 927
            |  ....:.:.:.|:|||||                  |.||    .:|||
  Fly   828 TGSAGDLLERQERQRMEAAG------------------VADL----LLGGG-------------- 856

  Fly   928 QNLSPLNSPGDFQP-HFLPKPMELQRDGVYNFNEMSSNLDAAWSAKPTNSYHLQRQLLENPHTAS 991
                   .||..:| |  |.|::|        .|:..:||...:.  ..|.....|.|.|    |
  Fly   857 -------VPGMPRPAH--PPPIDL--------TELGISLDNICAG--DKSIFGDTQTLTN----S 898

  Fly   992 MPELAGKLVAPPAHMQHLSQLHAVSSHQFQQHEYADILHPPPPPPGEIPELPTPNLSVASTALPP 1056
            ||::.            ||:  |..||.:|.   .|.::...|...::.:      |....|...
  Fly   899 MPDML------------LSK--ADDSHSYQS---IDKINLNSPSNSDLTQ------STQELANEL 940

  Fly  1057 ELMGSPTHS----------AGDRSLNTPMSTQSASHAPPHPVSILSGASSSSPMSGEPAKKKGVR 1111
            ||...|...          |.:|:...|............|:                   |.||
  Fly   941 ELDNEPVRELPHDGYEQLFANNRNQEHPAEQYDDEQLDNRPM-------------------KEVR 986

  Fly  1112 FEGIPDTLPRSRSYSGNGAGTSGGGERERDRDKDKEGGGRHGHGHSSRRRRRRKSSSSSSHHR-S 1175
            |..:.||:.||:||:.|                          .::.||||||..|.|||..: :
  Fly   987 FHSVQDTMSRSKSYTDN--------------------------SNARRRRRRRNQSRSSSEMQIN 1025

  Fly  1176 GSGHRSHSTTRADTYAPAQPLSSSYQGPPSVLQAANLVHESPSRQQREREREREREESEESDVCS 1240
            .:..|.|:   |.|.....||              ||::              ..:..:.:.:||
  Fly  1026 QTNLRLHN---AQTQVGTTPL--------------NLLN--------------NLDNCDVASICS 1059

  Fly  1241 TCSSSSSSS-EDYMMMYQLPQRRHYGGVRVSYVPNDALAYDRKRKPSE------------LGG-- 1290
            ||||||||. :||  :|:||.|:|||||||:|||||||||:||:|.::            :||
  Fly  1060 TCSSSSSSDMDDY--VYRLPARKHYGGVRVAYVPNDALAYERKKKMAQDSSLAPGAGNASVGGAP 1122

  Fly  1291 ---DKDKNCIIS 1299
               .:.|||.||
  Fly  1123 AIMHESKNCTIS 1134

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	85/94 (90%)
		LIM1_Prickle	624..682	CDD:188799	39/57 (68%)
		LIM2_Prickle	687..742	CDD:188802	46/54 (85%)
		LIM3_Prickle	747..805	CDD:188804	52/57 (91%)
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	85/95 (89%)
		LIM1_Prickle	593..651	CDD:188799	39/57 (68%)
		LIM2_Prickle	656..711	CDD:188802	46/54 (85%)
		LIM3_Prickle	716..774	CDD:188804	52/57 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456949
Domainoid	1	1.000	151	1.000	Domainoid score	I4309
eggNOG	1	0.900	-	-		E1_KOG1704
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	518	1.000	Inparanoid score	I1235
Isobase	1	0.950	-	0	Normalized mean entropy	S3648
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D34289at6960
OrthoFinder	1	1.000	-	-		FOG0001066
OrthoInspector	1	1.000	-	-		mtm6410
orthoMCL	1	0.900	-	-		OOG6_105250
Panther	1	1.100	-	-	P	PTHR24211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3342
SonicParanoid	1	1.000	-	-		X39
	13	12.780