DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pk and fhl2b

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_001006028.2	Gene:	fhl2b / 450007	ZFINID:	ZDB-GENE-041010-121	Length:	279	Species:	Danio rerio

Alignment Length:	274	Identity:	78/274 - (28%)
Similarity:	116/274 - (42%)	Gaps:	46/274 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   548 LYFSQIPDDKVPY-VNSPGEQYRVRQLLHQLPPHDN--EVRYCH-SLTDEERKELRLFSTQRKRD 608
            ||.:...:.|.|. .||....|:.|..      ||:  ....|| ||.|:.      |||:.:
Zfish    35 LYSNTCEECKKPIGCNSRDLSYKDRHW------HDDCFHCFKCHRSLVDKP------FSTKDE-- 85

  Fly   609 ALGRGNVRQLMS--------ARPCDGCDDLISTGDIAVFATRLGPNA-SWHPACFACSVCRELLV 664
                    ||:.        :..|..|...|..|     :.::.... |||..||.|..|::.:.
Zfish    86 --------QLLCTECYSNEYSSKCFECKKTIMPG-----SRKMEHKGNSWHETCFTCQRCQQPIG 137

  Fly   665 DLIYFHRDGRMYCGRHHAETLKPRCSACDEIILADECTEAEGRAWHMNHFACHECDKQLGGQRYI 729
            ...:..:|...||...:.:....:|..|.:.|.....|..: :.||.:.|.|..|.:||.|||:.
Zfish   138 TKSFIPKDNSNYCVPCYEKQFALQCVQCKKPITTGGVTYHD-QPWHKDCFLCTGCKQQLSGQRFT 201

  Fly   730 MREGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQ--MSHDGQHWHATDECFSCNTCRCSLLGRAFL 792
            .|:..||||:||..::|:.|..|...|....|.  :|.:.:.||  ::||:|..|..||:||.||
Zfish   202 SRDDFPYCLNCFCNLYAKKCAACTTPISGLGGSKYISFEERQWH--NDCFNCKKCSVSLVGRGFL 264

  Fly   793 PRRGAIYCSIACSK 806
            ..|..|.|. .|.|
Zfish   265 TERDDILCP-ECGK 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	18/73 (25%)
		LIM1_Prickle	624..682	CDD:188799	14/58 (24%)
		LIM2_Prickle	687..742	CDD:188802	20/54 (37%)
		LIM3_Prickle	747..805	CDD:188804	20/59 (34%)
fhl2b	NP_001006028.2	LIM	<7..33	CDD:295319
		LIM	36..97	CDD:295319	19/82 (23%)
		LIM	101..157	CDD:295319	14/60 (23%)
		LIM3_Fhl2	162..218	CDD:188815	21/56 (38%)
		LIM4_FHL2	221..278	CDD:188817	22/60 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910