Protein Alignment pk and LMO7

DIOPT Version :10

• Sequence 1: NP_724538.1
• Gene: pk / 45343
• FlyBaseID: FBgn0003090
• Length: 1299
• Species: Drosophila melanogaster
• Sequence 2: XP_047286270.1
• Gene: LMO7 / 4008
• HGNCID: 6646
• Length: 1711
• Species: Homo sapiens
• Alignment Length: 1229
• Identity: 210/1229 - (17%)
• Similarity: 362/1229 - (29%)
• Gaps: 487/1229 - (39%)

  Fly    67 QKYYRQLYSKAAAQRLADANQEP-DNARDREYDTVDCDLIAGQLDAVEDADDGIDLGDHSSTPKG 130
            ::.::::|.:..::.::|.:.|. .|.|...|:  :...|..||.. :|.....||.......|.
Human   677 ERLFQKIYGENGSKSMSDVSAEDVQNLRQLRYE--EMQKIKSQLKE-QDQKWQDDLAKWKDRRKS 738

  Fly   131 GATTAGRPLFPHSSSPRRSKKLLRSLRAHVRGEKLPKNDTTTANESSEVTQRNARVTVLDDPFLF 195
                       ::|..::.|:....:..... ||..::..|......:...:|.:.||.....::
Human   739 -----------YTSDLQKKKEEREEIEKQAL-EKSKRSSKTFKEMLQDRESQNQKSTVPSRRRMY 791

  Fly   196 GIDADHLGDLVVRGKRYSTLDATENMARFYAEQEATAQVLEIIEQEEESPEQEAPKPALPPKQKQ 260
            ..|     |::..|||..|:..:|  |.:.:|:         :|::..:...|.||.......|:
Human   792 SFD-----DVLEEGKRPPTMTVSE--ASYQSER---------VEEKGATYPSEIPKEDSTTFAKR 840

  Fly   261 QRPVPPLPPPPANRVTQDQGTQPAAP-QVPLQPLTAGDLQFLNLSLRQR-----------SLPRS 313
            :           :|||    |:...| |.|::..:...|.    |||.|           |||||
Human   841 E-----------DRVT----TEIQLPSQSPVEEQSPASLS----SLRSRSTQMESTRVSASLPRS 886

  Fly   314 M--------------KPF-----------------------KDAHDISFTFNELDTSAEP----- 336
            .              :||                       .|..||..|.|.:.::..|
Human   887 YRKTDTVRLTSVVTPRPFGSQTRGISSLPRSYTMDDAWKYNGDVEDIKRTPNNVVSTPAPSPDAS 951

  Fly   337 EVATGAAQQE----SNEPISRTPLTQISYLQKIPTLPRHFSPSGQGLATPPALGS-GGMGLPSSS 396
            ::|:..:.|:    :.|.::|.|         .||.|.......|...:...|.| .|:.|.|.|
Human   952 QLASSLSSQKEVAATEEDVTRLP---------SPTSPFSSLSQDQAATSKATLSSTSGLDLMSES 1007

  Fly   397 SASALYAAQAAAGILPTSP-LPLQRHQQYLPPHH---QQHPGAGMGPG-------PG---SGAAA 447
            ....:            || ..:.|.|.......   .|.||..:..|       ||   :...|
Human  1008 GEGEI------------SPQREVSRSQDQFSDMRISINQTPGKSLDFGFTIKWDIPGIFVASVEA 1060

  Fly   448 GPPL---------------GPQYSPGCSANPKYSNAQLPPPPH------HHHQLSPALSTPSPPS 491
            |.|.               ..::|...|...:.:.|:.....|      .:.:.......||.|.
Human  1061 GSPAEFSQLQVDDEIIAINNTKFSYNDSKEWEEAMAKAQETGHLVMDVRRYGKADWGKDQPSLPF 1125

  Fly   492 LLHHPAGGTS----------------------------------------SASAHAPFLGGPH-- 514
            :.|.....||                                        |::..:..:.|.|
Human  1126 IRHKTLNLTSMATKIIGSPETKWIDATSGIYNSEKSSNLSVTTDFSESLQSSNIESKEINGIHDE 1190

  Fly   515 --------------MDMQRQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPG 565
                          .:::|:|...:.........:||......|.|      :||..||.:::|.
Human  1191 SNAFESKASESISLKNLKRRSQFFEQGSSGFSYSSWVYLCGSSDSV------VPDLPVPTISAPS 1249

  Fly   566 ------EQYRVRQLLHQLPPHDNEVRYCHSLTDEERKELRLFSTQRKRDALGRGNVRQLMSARPC 624
                  |:.|.||...|    ..:.|........|:::|| ...||.:....|.|.:.|
Human  1250 RWVWDQEEERKRQERWQ----KEQDRLLQEKYQREQEKLR-EEWQRAKQEAERENSKYL------ 1303

  Fly   625 DGCDD---LISTGDIAVFATRLGPNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAETLK 686
               |:   ::|:..::: .||....|:|
Human  1304 ---DEELMVLSSNSMSL-TTREPSLATW------------------------------------- 1327

  Fly   687 PRCSACDEIILADECTEAEGRAWHMNHFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYCDY 751
                         |.|.:||               .....|...|.|:           .|....
Human  1328 -------------EATWSEG---------------SKSSDREGTRAGE-----------EERRQP 1353

  Fly   752 CGEAIGVDQGQMSHDGQHWHATDECFSCNTCRCSLLGRAFLPRRGAIYCSIACSKGEPPTPSDSS 816
            ..|.:..|||:...|                      :..:.|.         .|.|.....:..
Human  1354 QEEVVHEDQGKKPQD----------------------QLVIERE---------RKWEQQLQEEQE 1387

  Fly   817 GTGMYTTPTPPTQRVRPHPQAPLPARIPSSHASSSPPMSPQQQQQHQATFNQ----AMYQMQ--- 874
                       .:|::               |.:.....|.::|:.||...:    .:||.:
Human  1388 -----------QKRLQ---------------AEAEEQKRPAEEQKRQAEIERETSVRIYQYRRPV 1426

  Fly   875 -----SQQMEAAGGLV--DQSKSYAASDSD------AGVVKDLEHGGHM-------------GGG 913
                 .:..||:.|.:  |::||.:.::.|      .|..|.|:..|:|             .|.
Human  1427 DSYDIPKTEEASSGFLPGDRNKSRSTTELDDYSTNKNGNNKYLDQIGNMTSSQRRSKKEQVPSGA 1491

  Fly   914 DL----------------TDFSGGRASSTSQNLSPLNSPGDFQPHFLPKPMELQRDGVYNFNEMS 962
            :|                .|.|..|..|.|.|..|::.||            :.|.|     |..
Human  1492 ELERQQILQEMRKRTPLHNDNSWIRQRSASVNKEPVSLPG------------IMRRG-----ESL 1539

  Fly   963 SNLDA---------AWSAKPTNSYHLQRQLLENPHTASMPELAGKLVAPPAHMQHLSQLHAVSSH 1018
            .|||:         .|..:||..|          .::|:.:.:    .||      .||.:.|:.
Human  1540 DNLDSPRSNSWRQPPWLNQPTGFY----------ASSSVQDFS----RPP------PQLVSTSNR 1584

  Fly  1019 QFQQHEYADILHPPPPPPGEIPELPTPNLSVASTALPPELMGSPTHS-AGDRSLNTPMS 1076
            .:.::..:.:   |||..|.:   .|....||:|..|.....||:.| :|.:..|..:|
Human  1585 AYMRNPSSSV---PPPSAGSV---KTSTTGVATTQSPTPRSHSPSASQSGSQLRNRSVS 1637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	22/100 (22%)
		LIM1_Prickle	624..682	CDD:188799	6/60 (10%)
		LIM2_Prickle	687..742	CDD:188802	7/54 (13%)
		LIM3_Prickle	747..805	CDD:188804	7/57 (12%)
LMO7	XP_047286270.1	CH_SF	<42..100	CDD:469584
		DUF4757	213..>275	CDD:464950
		DUF4757	627..774	CDD:464950	18/111 (16%)
		PDZ	1042..1110	CDD:214570	10/67 (15%)
		DUF5401	<1258..>1506	CDD:375164	57/395 (14%)
		LIM	1642..1700	CDD:259829