Protein Alignment pk and Prickle4

DIOPT Version :10

• Sequence 1: NP_724538.1
• Gene: pk / 45343
• FlyBaseID: FBgn0003090
• Length: 1299
• Species: Drosophila melanogaster
• Sequence 2: NP_001277266.1
• Gene: Prickle4 / 381104
• MGIID: 2685785
• Length: 369
• Species: Mus musculus
• Alignment Length: 904
• Identity: 173/904 - (19%)
• Similarity: 293/904 - (32%)
• Gaps: 318/904 - (35%)

  Fly     7 KIRVAVRVRPFNERELEGNPRNIIKVLDKST--------LMFDPDEDEDEFFFHGVKLTHRDITK 63
            :::...|:...|..:|.|..:..:..|.:||        |:|..:|     .||..::.......
Mouse   504 RLKAGDRLIEVNGVDLAGKSQEEVVSLLRSTKMEGTVSLLVFRQEE-----AFHPREMNAEPSQM 563

  Fly    64 RVKKKLTMEYDDVFDNTATNNDI--FEVCMKPLVQSVMNGYNCSVFVYGATGAGKTHTMLGNETC 126
            :..|:...|.:|:........:.  |||   ||..|            |:.|.|.  ::.||.
Mouse   564 QSPKETKAEDEDIVLTPDGTREFLTFEV---PLNDS------------GSAGLGV--SVKGNR-- 609

  Fly   127 PGITFLTVKELFRQIESLSEVRKFDIGISYLEVYNELVMNLLTKSGPLKLREDSHGVVVSGLVLK 191
                              |:....|:||....:.|.   ...:|.|.|::.:....|....|:.|
Mouse   610 ------------------SKENHADLGIFVKSIING---GAASKDGRLRVNDQLIAVNGESLLGK 653

  Fly   192 QIHNATELLELLALGNRNRTQHPTDANAESSRSHAIFQVHIRMVE-KKTGQKRAVKLSM-IDLAG 254
            ....|.|.|         |....|:.|........:.:...|..| :..|...|.:|.: .:|..
Mouse   654 ANQEAMETL---------RRSMSTEGNKRGMIQLIVARRISRCNELRSPGSPAAPELPIETELDD 709

  Fly   255 SERAASTKGVGIRFKEGANINKSLLALGNCINKLADGLKHIPYRDSNLTRILKDSLGGNCQ---- 315
            .||               .|:.||.: |      .:||...|.|::.|:||:     |.||
Mouse   710 RER---------------RISHSLYS-G------IEGLDESPTRNAALSRIM-----GKCQLSPT 747

  Fly   316 -------TVMIAN-----ISP------SSLTYDDTYNTLKYASRAKK--IRTTVRQNIVPSNVPK 360
                   ||||.:     :.|      ||.::||....:..|....|  |..:...::.|...|
Mouse   748 VNMPHDDTVMIEDDRLPVLPPHLSDQSSSSSHDDVGFIMTEAGTWAKATISDSADCSLSPDVDP- 811

  Fly   361 EFLVKKVNEQAEELERLRAKVADLEEQLRKKEQEAAAAA---PGPSLALNAT----LLSTWVSRI 418
                    ..|.:.|....::|| |.:|...:.:.|.:.   .||||.|..:    .|.|.|:.:
Mouse   812 --------VLAFQREGFGRQIAD-ETKLNTVDDQRAGSPNRDVGPSLGLKKSSSLESLQTAVAEV 867

  Fly   419 D------------------SCYASMRQALQHLIALKSKEKLL------NMRVKLKEQAETIAR-- 457
            .                  .|..|.|.|:.     ||.:|.:      .|.. |:|..|..:|
Mouse   868 TLNGNIPFHRPRPRIIRGRGCNESFRAAID-----KSYDKPMVDDDDEGMET-LEEDTEESSRSG 926

  Fly   458 ---IVT------------LDGSHLNEDIAKMEASVDRCGKQVANQQADKTRWQERFRQSLRSRNA 507
               :.|            ::|.....|  |.|...|:.||       ||.:.:|:.:..|:::
Mouse   927 RESVSTSSDQPSYSLERQMNGDPEKRD--KAEKKKDKAGK-------DKKKDREKEKDKLKAK-- 980

  Fly   508 LRKEIAQSELATVLKGILTG-----------KDAEIEALQATLYKEHVLQMSFTYAQENKLWHNI 561
                          ||:|.|           ||.::|.:...     .:|.||| ::|::
Mouse   981 --------------KGMLKGLGDMFRFGKHRKDDKMEKMGRI-----KIQDSFT-SEEDR----- 1020

  Fly   562 MVLSGDIIQQNYLLLRSMDRLDNVTYDKLKRLVKLNQRQRGVTFFDDDGQQQDRNDIDLSSNSLD 626
                                            |::.:.|..:.....:.:::...:.|.:  .:.
Mouse  1021 --------------------------------VRMKEEQERIQAKTREFRERQARERDYA--EIQ 1051

  Fly   627 DIANLSDCSED-------------AVDFPPDGEDEDGSTMRSVVGGAAGGAMKRSKLNDGSESEP 678
            |......|.::             |::..|....| |..|.::.  |.....:.||..|.:.|.|
Mouse  1052 DFHRTFGCDDELLYGGMSSYDGCLALNARPQSPRE-GHLMDTLY--AQVKKPRSSKPGDSNRSTP 1113

  Fly   679 ETCSLQGDSANEDTATE-RNIFKKPKMVS------RTMSFKTTSLAGGGILSRPPISRRTPTKQA 736
                     :|.|.... |..|::.|...      ||.||:.:..:     |||          |
Mouse  1114 ---------SNHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQSWSS-----SRP----------A 1154

  Fly   737 KVTGKTTATTTTATVSHRLKVPRLVVSQAMMDSLSKKKVPQSPSGDIADKNKLNVSDDS 795
            ..:|:       .:||..::|.|  ..|...:|..:.:...|.....:.||..:||.||
Mouse  1155 SQSGR-------HSVSVEVQVQR--QRQEERESFQQAQRQYSSLPRQSRKNASSVSQDS 1204

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	13/105 (12%)
		LIM1_Prickle	624..682	CDD:188799	13/70 (19%)
		LIM2_Prickle	687..742	CDD:188802	14/61 (23%)
		LIM3_Prickle	747..805	CDD:188804	13/49 (27%)
Prickle4	NP_001277266.1	PET_OEBT	1..116	CDD:193603
		LIM1_Testin_like	124..181	CDD:188726
		LIM2_Testin_like	187..241	CDD:188727