DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pk and Lmo7

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	XP_036014595.1	Gene:	Lmo7 / 380928	MGIID:	1353586	Length:	1807	Species:	Mus musculus

Alignment Length:	1257	Identity:	220/1257 - (17%)
Similarity:	380/1257 - (30%)	Gaps:	410/1257 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 QKYYRQLYSKAAAQRLADANQEP-DNARDREYDTVDCDLIAGQLDAVEDADDGIDLGDHSSTPKG 130
            ::.::::|.:..::.::|.:.|. .|.|...|:  :...|..||.. :|.....||....:..|.
Mouse   705 ERLFQKIYGENGSKSMSDVSAEDVQNLRQVRYE--EMQKIKSQLKE-QDQKWQDDLAKWKNRRKS 766

  Fly   131 GATTAGRPLFPHSSSPRRSKKLLRSLRAHVRGEKLPKNDTTTANESSEVTQRNARVTVLDDPFLF 195
                       ::|..::.|:    .|..:..:.|.|:|.::......:..|.:|
Mouse   767 -----------YTSDLQKKKE----EREEIEKQALEKSDRSSKTFREMLQDRESR---------- 806

  Fly   196 GIDADHLGDLVVRGKR-YSTLDATENMARFYAEQEATAQVLEIIEQEEESPEQEAPKPALPPKQ- 258
                   |..|...:| ||:.|..::     .....|..:.|...|.|...::....||..||:
Mouse   807 -------GSTVTSWRRTYSSDDILDD-----GVLPPTVTLSETSYQSERLEDEARAHPAEMPKED 859

  Fly   259 ----------------------KQQRPVPPLPPPPANRVTQDQGTQPAAPQVPLQPLTAGDLQFL 301
                                  ::||    |.|.|:....|..|:.....|.||
Mouse   860 STTFANREDSVVAETQLASHSPEEQR----LAPSPSEEPRQASGSSAEPHQAPL----------- 909

  Fly   302 NLSLRQRSLPRSMKPFKDAHDISFTFNELDTSAEPEVATGAAQQESNEPISRTPLTQISYLQKIP 366
             ||...|..|   .|.::.|..|.:    .|...|   :..:.|:|..  :|...|:||     .
Mouse   910 -LSTEPRRTP---LPSEEPHQASLS----STLQRP---SSLSSQQSWS--TRAESTRIS-----A 956

  Fly   367 TLPRHFSPSG----QGLATPPALGSGGMG---LPSSSSASALYAAQAAAGILPTSPLPLQRHQQY 424
            :|||.:..:.    ..:.|....|:...|   ||.|.:....:.......::....|.|
Mouse   957 SLPRSYQRTDTARLTSVVTARPFGTSSRGISSLPRSYTMDDGWKYNGDVEVVKREQLDL------ 1015

  Fly   425 LPPHHQQHPGAGMGPGPGSGAAAGPPLGPQYSPGCSANPKYSNAQLPPPPHHHHQLSPALSTPSP 489
                     |...||.|.|.         .:..| ||:.|...|.         :...:||:|:.
Mouse  1016 ---------GRATGPKPDSS---------HFISG-SASEKEVIAT---------EDVASLSSPTL 1052

  Fly   490 P--SLLHHPA----------GGTSSASAHAPFLGGPHMDMQRQSHSDDDSGCALEEYTWVPPGLR 542
            |  ||.|..|          .|..|.|......|.|..::.|......|...::.:    .||.:
Mouse  1053 PSSSLSHDRAVSSKATFSSMSGLDSVSDSGEGRGSPLREVSRSLDQFSDMRVSINQ----TPGNK 1113

  Fly   543 P--------DQVRLY-----------FSQIP-DDKVPYVNSPGEQYRVRQLLHQLPPHDNEVRYC 587
            |        |...::           |||:. ||::..:|:....|:
Mouse  1114 PVFGFTIKWDISGIFVASVEQGSPAEFSQLQVDDEILAINNTKFSYK------------------ 1160

  Fly   588 HSLTDEERKELRLFSTQRKRDALGRGNVRQLMSARPCDGCDDLISTGDIAVFATRLGPNASW--- 649
                |.::.|..:.:.|                           .||::.:...|.| .:.|
Mouse  1161 ----DTKKWEEVMANAQ---------------------------ETGNLVMDVRRYG-KSDWGKD 1193

  Fly   650 --------HPACFACSVCRELL-------VDL---IY-FHRDGRMYCGRHHAETLKPRCSACDEI 695
                    |......||..:::       :|.   || ..:...:......:|:|:...:
Mouse  1194 QPSLPFIRHKTLNLTSVATKIIGSSETKWIDTTSGIYNSDKSSSLSVTTDFSESLQSPYT----- 1253

  Fly   696 ILADECTEAEGRAWHMNHFACHECD----KQLGGQRYIMREGKPYCLHCFDAMFAEYCDYCGEAI 756
                |..|..|.....|.|.....:    |.|..:.....:|.|      ...::.:...||.:.
Mouse  1254 ----ESKEVNGIHEESNPFDSKASESISLKNLKRRSQFFEQGWP------GFSYSSWVYLCGSSD 1308

  Fly   757 GV-----------------DQGQMSHDGQHW---------------------------------- 770
            .|                 ||.:.....:.|
Mouse  1309 SVAPDLPVPTLSAPSRWAWDQEEERRRQERWQKEQDRLLQEKYQREQEKLREEWQRAQQEAEREN 1373

  Fly   771 --HATDECFSCNTCRCSLLGRAFLPRRGAIYCSIACSKGEPPTPSDSSGT-------------GM 820
              :..:|....|:...||..|.      .:..:...:..|.....||.||             .:
Mouse  1374 SKYLDEELMVLNSNSISLTSRE------PVAATWEATWSEGSKSLDSEGTRAGEEDRGQLEDDAV 1432

  Fly   821 YTTPTPPTQRV-----RPHPQAPLPARIPSSHASSSPPMSPQQQQQHQATFN---QAMYQMQSQQ 877
            |...:...|.:     |...:|....|.....|.:......:...:.||...   :|..:.|::.
Mouse  1433 YEDQSQKLQELEQEKKRKEQEAQEEERRKQREAQAWAEAEAKAWAEAQARAEAEAKARAEAQARA 1497

  Fly   878 MEAAGGLVDQSKSYAASDSDAGVVKDLEHGGHMGGGDL----TDFSG------GRASSTSQNLSP 932
            ...|....:..|..|..:.:.. ||..::...:...||    .|.||      .::.||::...|
Mouse  1498 EAEAQKRAEAQKLQAERERETS-VKIYQYRRPIDSYDLPKREDDTSGMLPTDRSKSRSTTELNDP 1561

  Fly   933 L---NSPGDFQPHFLPKPMELQRDGVYNFNEMSSNLDAAWSAKPTNSYHLQRQLLENPHTASMPE 994
            |   |....:.          :|.|..:|:..||..|.|    |:.:...::|:|:
Mouse  1562 LIEKNGSSKYS----------ERIGATSFSHRSSKKDQA----PSEAELERQQILQ--------- 1603

  Fly   995 LAGKLVAPPAHMQHLSQLHAVSSHQFQQHEYADILHPPPPPPGEIPELPTPNLSVASTALPPELM 1059
                      .|:..:.||  :.:.:.:...|.:...|...||.:..  ..:|....:..|....
Mouse  1604 ----------EMRKRTSLH--NDNSWIRQRSASVNKEPICLPGIMRR--GESLDNLDSQRPGSWR 1654

  Fly  1060 GSPTHS--AGDRSLNTPMSTQSASHAPPHPVSILSGASSSSPMSGEPAKKKGVRFE-GIPDTLPR 1121
            .||.||  ||   :....|.|..|..||..:|..:.|...:|.|..|.....|:.. |.|.  ||
Mouse  1655 QSPWHSQPAG---VYASSSVQDFSRPPPQLLSTSNRAYMRNPSSAVPPPAGSVKTSPGSPS--PR 1714

  Fly  1122 SRSYSGNGAGT-----SGGGER 1138
            |.|.|.:.:|:     |..|:|
Mouse  1715 SHSPSMSQSGSQLRNRSVSGKR 1736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	15/114 (13%)
		LIM1_Prickle	624..682	CDD:188799	11/79 (14%)
		LIM2_Prickle	687..742	CDD:188802	9/58 (16%)
		LIM3_Prickle	747..805	CDD:188804	11/110 (10%)
Lmo7	XP_036014595.1	CH_LMO7	14..129	CDD:409126
		DUF4757	242..>314	CDD:406382
		DUF4757	655..802	CDD:406382	19/114 (17%)
		fibronec_FbpA	<829..>930	CDD:411474	25/119 (21%)
		PDZ	1114..1183	CDD:238080	14/117 (12%)
		LIM	1738..1796	CDD:259829
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900