DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pk and scel

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	XP_005168027.1	Gene:	scel / 368684	ZFINID:	ZDB-GENE-030616-15	Length:	612	Species:	Danio rerio

Alignment Length:	783	Identity:	119/783 - (15%)
Similarity:	238/783 - (30%)	Gaps:	238/783 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 TVTATGNMEPAMVPRTANLLACKQWWRVCFLYGDQQKYYRQLYSKAAAQRLADANQEPDNARDRE 96
            |.::||::.|....:....|.....|....:..||:......:.|....|. .:|:...:.:|:.
Zfish    13 TTSSTGSINPVNESKKKTSLLKDNSWIKSNVNEDQKVEQETNFGKTVLSRY-KSNESLTSPQDKT 76

  Fly    97 YDTVDCDLIAGQLDAVEDADDGIDLGDHSSTPKGGATTAGRPLFPHSSSPRRSKKL------LRS 155
            ..|                          .|.....||:     |.||....||:.      |..
Zfish    77 SKT--------------------------ETKTTTVTTS-----PGSSVQALSKRFGGSQDKLNE 110

  Fly   156 LRAHVRG---EKLPKNDTTTANESSEVTQRNARVTVLDDPFLFGIDADHLGDLVVRGKRYSTLDA 217
            .|..:..   :.||:..||    |:..|.:|...|.                       .:|:..
Zfish   111 TRTPLNKPSVKSLPRTSTT----STTTTVKNGTKTT-----------------------ETTVTT 148

  Fly   218 TENMARFYAEQEATAQVLEIIEQEEESPEQEAPKPALPPKQKQQRPVPPLPPPPANRVTQDQGTQ 282
            |        :|:......::....:.:|...:.:.....|..:|..:    ...:::.|.|..:.
Zfish   149 T--------KQDVVKSSTKLETVNDRNPADSSTRRTGDYKTTRQEDI----TVKSSKDTVDGPSS 201

  Fly   283 PAAPQVPLQPLTAGDLQFLNLSLRQRSLPRSMKPFKDAHDISFTFNELDTSAEPEVA---TGAAQ 344
            |......::..|..|:      |..::.|.|::..|.:.:::.|.:.:.|:.:||::   |....
Zfish   202 PVKTTTSIKSYTKEDV------LPAKTTPYSVQSTKSSENLTPTSSIMTTNTKPEISDSKTEVVT 260

  Fly   345 QESNEPISRTPLTQISYLQKIPTLPRH-FSPSGQGLATPPALGSGGMGL-------PSSSSASAL 401
            .:|::.|..||.:.:.....|.|..:. .:.:.....|.|...:..:..       |:.|:.:..
Zfish   261 VKSSKTIIDTPASPVKTTTSIKTYTKEDVTSTNTKRPTSPVKTTTSIKTFTKEDVSPAKSTTTTT 325

  Fly   402 YAAQA-----AAGI--------LPTSPLPLQRHQQYLPPHHQQHPGAGMGPGPGSGAAAGPPLGP 453
            |..::     .|.:        :|.||:   :....:..:.::.             ...|...|
Zfish   326 YTTKSDYKTEVATVKSSKDIIDIPASPV---KTTTSIKTYTKED-------------VTSPKTTP 374

  Fly   454 QYSPGCSANPKYSNAQLPPPPHHHHQLSPALSTPSPPSLLHHPAGGTSSASAHAPFLGGPHMDMQ 518
             ||...:.:.|......|.........:..::..|...::..|.....:.::::
Zfish   375 -YSVRSTKSSKDFLYDTPTKTSISDYKTEVVTVNSSKDIVDIPTSPVKTTTSYS----------- 427

  Fly   519 RQSHSDDDSGCALEEYTWVPPGLRPDQVR--------LYFSQIPDDKVPYVNSPGEQYRVRQLLH 575
            .:|::.:|..         |.....|.:|        ||.:.||
Zfish   428 IKSYTKEDVS---------PTKTTSDSIRSTKSSEDLLYDTLIP--------------------- 462

  Fly   576 QLPPHDNEVRYCHSLTDEERKELRLFSTQRKRDALGRGNVRQLMSARPCDGCDDLISTGDIAVFA 640
                  ..::..:|..|..|::|....|.|                       .:.||.|...::
Zfish   463 ------LSIKSTNSKPDSSREDLSSSKTVR-----------------------TVYSTIDRNEWS 498

  Fly   641 TRLGPNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAETLKPRCSACDEIILADE----- 700
            |.|.|  |:....:..|...|.:.|.:.......:|.........|..|:.|::.:..||
Zfish   499 TDLSP--SYTRTSYTESRPFEYMSDSLTSKTTTTVYSSPERKVNAKDICTYCNQSMYTDEKFILD 561

  Fly   701 -----CTEAEGRAWHMNHFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYCD-YCGEAIGVD 759
                 |        |...|.|..|:..||.    :|.|        |:::...|. :|....||.
Zfish   562 DMNINC--------HARCFKCGVCNTSLGN----LRAG--------DSLWVYQCAIHCASCFGVT 606

  Fly   760 QGQ 762
            :.:
Zfish   607 KNK 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	14/102 (14%)
		LIM1_Prickle	624..682	CDD:188799	11/57 (19%)
		LIM2_Prickle	687..742	CDD:188802	13/64 (20%)
		LIM3_Prickle	747..805	CDD:188804	4/17 (24%)
scel	XP_005168027.1	LIM	544..>583	CDD:214528	10/46 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900