DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pk and prickle2b

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_899186.1	Gene:	prickle2b / 368250	ZFINID:	ZDB-GENE-030724-6	Length:	840	Species:	Danio rerio

Alignment Length:	893	Identity:	331/893 - (37%)
Similarity:	445/893 - (49%)	Gaps:	176/893 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   516 DMQRQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQYRVRQLLHQLPPH 580
            |.||.|.||||||||||||.||||||:|:||..|:|.:|:|||||||||||:||::|||||||||
Zfish    15 DFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSSLPEDKVPYVNSPGEKYRIKQLLHQLPPH 79

  Fly   581 DNEVRYCHSLTDEERKELRLFSTQRKRDALGRGNVRQL---MSARPCDGCDDLISTGDIAVFATR 642
            |||||:|:||.|||::||:|||.||||:.|||||||..   |:...|:.|...|:.|||||||:|
Zfish    80 DNEVRFCNSLDDEEKRELKLFSNQRKRENLGRGNVRPFPVTMTGAICEQCGGQINGGDIAVFASR 144

  Fly   643 LGPNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAETLKPRCSACDEIILADECTEAEGR 707
            .|....|||.||.||:|.|||||||||::||:::|||||||.|||||||||||||||||||||||
Zfish   145 AGHGVCWHPQCFVCSMCDELLVDLIYFYQDGKIFCGRHHAERLKPRCSACDEIILADECTEAEGR 209

  Fly   708 AWHMNHFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQHWHA 772
            .|||.||.|.||:..||||||||:||:|||..||::::|||||.|||.||:|||||::|||||||
Zfish   210 HWHMKHFCCFECETVLGGQRYIMKEGRPYCCTCFESLYAEYCDSCGEHIGIDQGQMTYDGQHWHA 274

  Fly   773 TDECFSCNTCRCSLLGRAFLPRRGAIYCSIACSKGEPPTPSDSSGTGMYTTPTPPTQRVRPHPQA 837
            |:.||||..|:.|||||.|||::|.|:||.|||.|:....||||.:...:..:...:|
Zfish   275 TEACFSCARCKKSLLGRPFLPKQGQIFCSRACSVGDEQNGSDSSDSAFQSARSREARR------- 332

  Fly   838 PLPARIPSSHASSSPPMSPQQQQQHQATFNQAM-----YQMQSQQMEAAGGLVDQSKSYAASDSD 897
                   ||..|:...........||:....||     ....|.||:    |:..|....:.:.:
Zfish   333 -------SSSKSNKSSTGGSGGDGHQSGKASAMRFSADVDPLSLQMD----LLSLSSQTPSLNRE 386

  Fly   898 AGVVK-DLEHGGHMGGGDLTD------FSGGRASSTSQNLSP--LNSPGDFQPHFLPKPMELQRD 953
            :...| ..|..|:.|..:|:.      ......:|.|.||||  |:.|...:|....:|......
Zfish   387 SPSWKTQAEMFGYEGRNELSTNPLHLLSQCNIRTSYSSNLSPGHLSDPRPKEPASSKRPPVSALK 451

  Fly   954 GVYNFNEMSSNLDAAWSAKPTNSYH-----LQRQLLENPHTASMPELAGKLVAPPAHMQHLSQLH 1013
            |        .:|:..|..:....|:     .|....|.||.:.|.:                  .
Zfish   452 G--------KSLNENWFQQGPEDYYPPALRTQASFNEVPHNSFMDK------------------R 490

  Fly  1014 AVSSHQFQQHEYADI------LHPPPPPPGEIPEL----PTPNLSVASTALP------------- 1055
            :||.|.||:.:..|:      ...|....|...:|    .||..|:.|.||.
Zfish   491 SVSLHVFQREKEKDVGPQMSRSRNPISALGFSEQLTPLEQTPRGSMESLALSNATGTSADGGSKR 555

  Fly  1056 ---------PELMGSPTHSAGDRS----LNTPM------STQSASHAPPH-----PVSILSGASS 1096
                     |:|......:..::|    ||:.:      |.:|.:.|.|:     ||.:
Zfish   556 QEHLSRFSMPDLSKDSGMNVSEKSNMGTLNSSVQFHSSESLRSLNSAQPYLELEAPVQV------ 614

  Fly  1097 SSPMSGEPAKKKGVRFEGIPDTLPRSRSY----------SGNGAGTSGGGERERDRDKDKEGGGR 1151
            ..|:. .|.:..|:      :.||...:|          :.|.|......||.|.|..|.|...|
Zfish   615 RFPVQ-YPREPSGI------NALPPGFAYQEEDRVSLVSNANNARLPPMSERTRRRSIDHEEPRR 672

  Fly  1152 HGHGHSSRRRRRRKSSS--------------SSSHHRSGSGHRSHSTTRADTYAPAQPLSSSYQG 1202
            ..|.|.|||.||.:|.:              |..|.|.............|||...:.....::
Zfish   673 RHHHHRSRRSRRSRSDNALNLVAERRPALKRSQLHAREDYDQFPLPRGSRDTYGSGRLRQQPFR- 736

  Fly  1203 PPSVLQAANLVHESPSRQQREREREREREESEESDVCSTCSSSS-SSSEDYMMMYQLPQRRHYGG 1266
             |.....::|..::|:..:.:.....::.:.:: |.|||||||| |..|.|.:...:|:     .
Zfish   737 -PCPRTTSDLTLQNPALHRHQGPYSWDQYDYDD-DWCSTCSSSSESEDEGYFLGEPIPR-----P 794

  Fly  1267 VRVSYVPNDALAYDRKRKPSELGGD---------------KDKNCIIS 1299
            :::.::.::.|.  ||...|.||..               |.||||||
Zfish   795 IQLRHMTSEELL--RKYNSSGLGASGQFGSRGQLHMRKRRKSKNCIIS 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	73/94 (78%)
		LIM1_Prickle	624..682	CDD:188799	35/57 (61%)
		LIM2_Prickle	687..742	CDD:188802	43/54 (80%)
		LIM3_Prickle	747..805	CDD:188804	40/57 (70%)
prickle2b	NP_899186.1	PET_Prickle	22..118	CDD:193602	73/95 (77%)
		LIM1_Prickle	126..184	CDD:188799	35/57 (61%)
		LIM2_Prickle	189..244	CDD:188802	43/54 (80%)
		LIM3_Prickle	249..307	CDD:188804	40/57 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586842
Domainoid	1	1.000	151	1.000	Domainoid score	I4309
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	518	1.000	Inparanoid score	I1235
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	1	1.000	-	-		FOG0001066
OrthoInspector	1	1.000	-	-		mtm6410
orthoMCL	1	0.900	-	-		OOG6_105250
Panther	1	1.100	-	-	LDO	PTHR24211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3342
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.930